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Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Self-organizing heart organoids created at the Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA) are also efficient injury and in vitro congenital disease models. These “cardioids” have the potential to transform studies into cardiovascular diseases and heart malformations.

21 May 2021

Study identifies new epigenetic control pathways in multiple myeloma growth

An international group of researchers from Japan, the United States, and the UK studied the role of the histone demethylase KDM5A in multiple myeloma.

18 May 2021

Study shows that inactivation of BRG1 leads to high genetic instability

Following the p53 tumor suppressor gene, the genes encoding two proteins of the SWI/SNF chromatin remodeling complex are the most often identified mutated.

17 May 2021

Scientists identify the language the body uses to marshal responses to threats

UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats.

13 May 2021

Supercoiling characteristic of DNA's structure controls gene expression, research shows

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later.

10 May 2021

Study reveals that bacteria DNA signals can be read either forward or backward

Bacteria’s DNA signals have symmetry that allows them to be read either backward or forward, challenging the current understanding of gene transcription.

7 May 2021

Research uncovers how antibiotics target bacterial RNA Polymerase to inhibit gene transcription

The emergence and spread of new forms of resistance remains a concern that urgently demand new antibiotics. Transcription is a vital process in bacterial cell, where genetic information in DNA is transcribed to RNA for the translation of proteins that perform cellular function.

6 May 2021

“Chemical nose” smells vital variations in unusual folding of DNA structures

Small variations in the structure of DNA have been related to breast cancer and other diseases, but they have been incredibly hard to find so far.

6 May 2021

Changes in protein provide a better understanding of age-related changes in the kidney

New research suggests that studying protein modifications in the kidneys as people age will help provide a complete picture of the age-related processes that occur in these organs.

6 May 2021

Study reveals relationship between form and function in the genetic material of dinoflagellates

A new study unfolds a longstanding puzzle about the connection between the function and form in the genetic material of a complex group of algae.

5 May 2021

Researchers study the unique genomic organization of coral symbionts

According to recent findings, the genome of single-celled plankton, called dinoflagellates, is arranged in an extremely unusual and strange manner. The study results set the foundations for further research into these vital aquatic species and significantly broaden the understanding of what a eukaryotic genome can look like.

3 May 2021

New gene editing tool helps analyze the mysterious quirk of bacteria

While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations.

3 May 2021

Researchers identify specific proteins that play a key role in the development of dendritic cells

The human immune system comprises functionally specialized cellular defense mechanisms that protect the body against disease.

3 May 2021

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.

30 Apr 2021

New chemical tool elucidates how proteins recognize and associate with one another

A University of Hong Kong research team has created a novel chemical method for illustrating protein interaction networks in cells.

29 Apr 2021

Study reveals RNA regulatory mechanisms within transcription-translation couplings

To gain a better understanding of how bacterial RNA gives rise to proteins scientists are now focusing on the special way this process takes place in bacteria.

15 Apr 2021

Study reveals DNA supercoiling is involved in regulating gene expression

The (when stretched) two-meter-long DNA molecule in each human cell is continuously being unpacked and packed again to enable the expression of genetic information.

15 Apr 2021

Study shows how nitrate presence controls nodule formation in legumes

Legumes, or plants belonging to the bean family, form nodules on their roots to absorb nitrogen.

12 Apr 2021

Tumor-inhibiting protein p53 boosts gene expression by bringing together nuclear speckles and DNA

Scientists at the University of Pennsylvania headed a group of researchers to unravel the functions of the so-called “nuclear speckles”.

6 Apr 2021

New mechanism of transcriptional regulators influences tumor development

The Wistar Institute scientists have discovered a novel mechanism of transcriptional regulation of cellular senescence that promotes the release of inflammatory molecules that, in turn, affect tumor growth by changing the surrounding microenvironment.

2 Apr 2021

Transcription News and Research

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Study identifies new epigenetic control pathways in multiple myeloma growth

Study shows that inactivation of BRG1 leads to high genetic instability

Scientists identify the language the body uses to marshal responses to threats

Supercoiling characteristic of DNA's structure controls gene expression, research shows

Study reveals that bacteria DNA signals can be read either forward or backward

Research uncovers how antibiotics target bacterial RNA Polymerase to inhibit gene transcription

“Chemical nose” smells vital variations in unusual folding of DNA structures

Changes in protein provide a better understanding of age-related changes in the kidney

Study reveals relationship between form and function in the genetic material of dinoflagellates

Researchers study the unique genomic organization of coral symbionts

New gene editing tool helps analyze the mysterious quirk of bacteria

Researchers identify specific proteins that play a key role in the development of dendritic cells

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

New chemical tool elucidates how proteins recognize and associate with one another

Study reveals RNA regulatory mechanisms within transcription-translation couplings

Study reveals DNA supercoiling is involved in regulating gene expression

Study shows how nitrate presence controls nodule formation in legumes

Tumor-inhibiting protein p53 boosts gene expression by bringing together nuclear speckles and DNA

New mechanism of transcriptional regulators influences tumor development

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