Cell Biology

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Endothelial Deletion of Wt1 Gene During Coronary Vessel Formation Affects Embryonic Heart Development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

Researchers Explain How a Single Mutation Causes Ataxia

Worldwide, only a handful of patients are known to suffer from episodic ataxia type 6, a neurological disease that causes transient loss of muscle control.

4 Apr 2023

Triglyceride Cycling Process Modifies Stored Fatty Acids

Fat molecules serve as energy storage for fat cells. They consist of three fatty acids attached to a backbone of glycerol.

4 Apr 2023

Cold Temperature Increases Human Life Expectancy

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

4 Apr 2023

SARS-CoV-2 Spike Protein Induces Memory Loss After COVID-19

Patients diagnosed with post-COVID-19 syndrome often experience cognitive and memory impairments.

4 Apr 2023

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors that don't typically respond to immune-based treatments. Shown is a 3D rendering of cancer cells.

4 Apr 2023

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

4 Apr 2023

MET+LEU Cocktail Prevents Cellular Senescence and Disrupted Proteostasis Induced by Myotube Atrophy

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 6, entitled, "Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail."

3 Apr 2023

Astrocytes in the Brain may Play a Key Role in Regulating Information

Long thought of as "brain glue," the star-shaped cells called astrocytes-;members of a family of cells found in the central nervous system called glial that help regulate blood flow, synaptic activity, keep neurons healthy, and play an important role in breathing.

3 Apr 2023

Study Represents a Paradigm Shift in Renal Physiology/Mammalian Salt Handling

A new study led by Marshall University researchers focuses on a novel mechanism of the body's regulation of salt balance.

3 Apr 2023

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

First Steps Driving Antibiotic Resistance Discovered

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

3 Apr 2023

New, Effective Method can Make Rare Cell Types and Disease Patterns Visible in Tissue

The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision.

3 Apr 2023

Two types of immune cells interact to give natural protection from tuberculosis

A new study has uncovered the role of B and T cells in controlling tuberculosis (TB) infections.

3 Apr 2023

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Metal labeling strategy for single-cell multiplexing with mass cytometry

Recently, a new metal labeling strategy has been suggested by researchers from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences (CAS) to boost mass cytometry’s sensitivity and increase the number of MC detection channels.

31 Mar 2023

Revealing the structural basis underpinning the biophysical properties of pili

According to the World Health Organization, enterotoxigenic Escherichia coli (ETEC) bacteria are the most common cause of traveler’s diarrhea and cause the greatest number of known community-acquired cases of childhood diarrhea in the developing world.

31 Mar 2023

Maternal vaginal microbiome does not substantially influence the infant stool microbiome

It has been a longstanding assumption that birth mode and associated exposure of newborns to their mothers' vaginal microbiome during delivery greatly affects the development of babies' gut microbiome.

31 Mar 2023

Previously unknown telomere and cancer connection to the immune system revealed

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

31 Mar 2023

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear. Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation.

31 Mar 2023

Cell Biology

Endothelial Deletion of Wt1 Gene During Coronary Vessel Formation Affects Embryonic Heart Development

Researchers Explain How a Single Mutation Causes Ataxia

Triglyceride Cycling Process Modifies Stored Fatty Acids

Cold Temperature Increases Human Life Expectancy

SARS-CoV-2 Spike Protein Induces Memory Loss After COVID-19

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

MET+LEU Cocktail Prevents Cellular Senescence and Disrupted Proteostasis Induced by Myotube Atrophy

Astrocytes in the Brain may Play a Key Role in Regulating Information

Study Represents a Paradigm Shift in Renal Physiology/Mammalian Salt Handling

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

First Steps Driving Antibiotic Resistance Discovered

New, Effective Method can Make Rare Cell Types and Disease Patterns Visible in Tissue

Two types of immune cells interact to give natural protection from tuberculosis

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Metal labeling strategy for single-cell multiplexing with mass cytometry

Revealing the structural basis underpinning the biophysical properties of pili

Maternal vaginal microbiome does not substantially influence the infant stool microbiome

Previously unknown telomere and cancer connection to the immune system revealed

Immune cells in human blood produce acetylcholine that regulates blood pressure and inflammation

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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