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Novel Active Substance Drives Cancer Cells Toward Self Destruction

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die.

20 Nov 2025

Innovative Human Cell Model Shows How Melanoma Thrives in the Brain

Using human cells and cutting-edge technology, the team created a three-dimensional (3D) model that accurately simulates the brain invaded by aggressive cancer.

19 Nov 2025

Cancer Cell Deformability Drives Movement Through Tight Tissue Gaps

Aggressive cancer cells are masters of movement. When they spread through the body, they cause metastasis, which significantly reduces a person's chance of survival.

19 Nov 2025

Sabotaging T Cell Exhaustion for Cancer Therapy

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired-so much so, in fact, that they can even die from exhaustion.

18 Nov 2025

Researchers Discover Molecular Switch That Helps Breast Cancer Cells Survive Stress

Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust their gene expression to protect themselves.

18 Nov 2025

CRISPR Gene Editing Reverses Chemotherapy Resistance in Lung Cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth.

18 Nov 2025

Blocking a Hidden Tumor Pathway Revives the Immune System

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them-and how silencing that signal could revive the body's immunity.

18 Nov 2025

Targeted Genetic Testing Revolutionizes Diagnosis of X-Linked Dystonia-Parkinsonism

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects primarily men of Filipino ancestry.

17 Nov 2025

Understanding Genetic Diversity Through Short Tandem Repeats

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.

17 Nov 2025

Brain Immune Cells Found to Act as Accelerators and Brakes for Anxiety

Anxiety disorders are some of the most common mental health conditions in America, affecting about one in five people nationwide.

12 Nov 2025

Rare Stress-Sensitive Neurons Hold the Key to Healthy Brain Blood Flow

While the exact causes of neurodegenerative brain diseases like Alzheimer's and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow.

12 Nov 2025

Transforming Stomach Cells into Insulin Factories for Diabetes Treatment

Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide.

7 Nov 2025

Ferroptosis Suppression Identified as a Key Driver of Lung Cancer Growth

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

6 Nov 2025

New Genomic Method Unlocks Diagnoses for Rare Conditions

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable by identifying complex structural genetic changes that are often missed by standard tests.

4 Nov 2025

Study Reveals Shared Genetic Roots Between ALS and Hereditary Spastic Paraplegia

Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical similarities but have been largely viewed as genetically distinct.

3 Nov 2025

Cross-Ancestry Genomic Study Identifies Thirteen Genes Linked to Obesity

Obesity is a global epidemic affecting millions of people every day and is associated with comorbidities ranging from heart disease and Type 2 diabetes to osteoarthritis and social stigma.

31 Oct 2025

Genetic Variants Reveal Unexpected Link Between Obesity Risk and Cholesterol Levels

Individuals with a genetic profile that puts them at risk of obesity may not necessarily be at risk of having high cholesterol, UTHealth Houston researchers discovered.

31 Oct 2025

New Method Doubles Therapeutic Cell Production for Duchenne Muscular Dystrophy

If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.

31 Oct 2025

Protein Dysfunction Could be the Cause of Diseases Resulting From Shortened Telomeres

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025