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Inherited Genetic Pathways Shape Individual Cancer Risk and Outcomes

Why do two people with the same cancer diagnosis-the same stage, the same cell type, and the same clinical profile-often have completely different outcomes? For decades, scientists have studied acquired mutations in cancer to find answers, but mutations alone explain only part of the story.

12 May 2026

Epigenetic Changes May Influence Inheritance Beyond DNA Sequence Alone

When we think about genetic inheritance, we usually leap to DNA, the four-letter code containing the instructions for building a living organism.

11 May 2026

Extra Chromosomes Trigger Cellular Changes Linked to Tumor Aggressiveness

One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment.

11 May 2026

DNA Study Reveals the Personal Pathways Behind Different Tumors

Why do two individuals with the identical cancer diagnosis—the same cell type, the same stage, and the same clinical profile—often experience very different outcomes? Scientists have been researching acquired mutations in cancer for decades in an effort to uncover solutions, but mutations by themselves only account for a part of the problem.

11 May 2026

Breakthrough CRISPR Discovery Enables Selective Destruction of Cancerous Cells

Among the challenges in treating disease, including cancer, is wiping out malignancies, infection, contaminants or other pathologies, without destroying healthy tissue.

7 May 2026

New Epigenetic Marker Reveals Lasting Impact of Arsenic Exposure

Public health experts estimate that more than 200 million people worldwide are exposed to arsenic through contaminated drinking water.

5 May 2026

Metabolic Pathway Loss Makes Cancer Cells Vulnerable to PARP Drugs

Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their vulnerability to a class of anticancer drugs known as PARP inhibitors, a study led by UT Southwestern Medical Center researchers shows.

5 May 2026

Cells Use a Timing Mechanism to Filter Persistent Physical Forces

Scientists have discovered how cells decide when to respond to physical forces, potentially opening new avenues for tackling diseases such as cancer and fibrosis.

30 Apr 2026

Magnetic Microrobots That Could Transform Cancer Treatment

Cancer treatments and other delicate medical procedures might one day be performed using tiny microrobots that are precisely directed within the body, according to a new magnetic tool created by scientists.

29 Apr 2026

MD Anderson Researchers Map DNA Replication Stress at Single-Cell Resolution

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with single-cell resolution.

28 Apr 2026

Obesity Leaves Persistent Epigenetic Marks on Immune Cells

People who live with obesity are 'tagging' a memory of being overweight on a key part of the immune system - leaving people with ongoing risk of obesity-related conditions years after losing weight, according to a 10 year-long study published in EMBO Reports.

28 Apr 2026

Advances in Proteomics Accelerate Precision Oncology and Biomarker Discovery

A recent review shows that proteomics-driven multi-omics integration reveals tumor heterogeneity and functional regulatory networks beyond genomic information, facilitating the discovery of clinically relevant biomarkers and therapeutic targets.

28 Apr 2026

Lund Researchers Map Epigenome Secrets of Insulin and Glucagon Cells

Researchers at Lund University in Sweden have carried out the most detailed mapping to date of the epigenome in the cells that regulate the body's blood sugar levels.

27 Apr 2026

New Genetic Pathways Linked to Cardiometabolic Disease Identified

A study published today in PLOS Medicine has identified two new genetic pathways that contribute to cardiometabolic disease, which includes heart disease, obesity and diabetes.

24 Apr 2026

Stress Response in Polyploid Cells Fuels Cancer Progression

One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment.

24 Apr 2026

New Method Predicts Cancer Patient Outcomes at Single-Cell Resolution

Oregon Health & Science University researchers have developed a first-of-its-kind method to predict cancer patient survival using advanced molecular data from individual cells.

22 Apr 2026

Brain Immune Cells Play Key Role in Glioblastoma Tumor Infiltration

Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it can infiltrate surrounding brain tissue and spread far beyond the main tumor.

22 Apr 2026

Structured National Genomic Program can be Effective for Rare Disease Diagnosis

For many families, eight years of uncertainty meant repeated specialist visits, inconclusive genetic tests and the growing fear that a clear answer might never come. For nearly half of the children enrolled in the Telethon Undiagnosed Disease Program (TUDP), that wait is now over.

21 Apr 2026

Researchers Develop 3D Organoids that Reflect the Complexity of Brain Tumors

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

16 Apr 2026

New Technology Tracks Real-Time Gene Activity to Find Common Disease Targets

Diseases like cancer or neurodegeneration are known to arise from genetic misfires. But treating such complex conditions hasn't been simply a matter of identifying the malfunctioning genes involved. With hundreds of genetic mutations spanning diverse pathways at play, connecting the dots between a constellation of mutations and a specific outcome has proved to be enormously difficult.

16 Apr 2026