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Molecular Switch Links Mitochondrial Stress to T Cell Exhaustion

Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed.

19 Mar 2026

Engineered Bacteria Deliver Targeted Anticancer Therapy in Tumors

Every year, millions of people are diagnosed with cancer globally; however, current treatments are limited by disease complexity.

18 Mar 2026

Cancers Use Lipids Produced by Lung Cells to Support Metastatic Tumor Growth

Scientists from the VIB–KU Leuven Center for Cancer Biology, in collaboration with the Francis Crick Institute, have discovered how cancer cells can exploit healthy lung cells to support metastatic tumor growth in the lungs.

18 Mar 2026

Epigenetic Switch Discovery Opens New Target for Cancer Therapy

Cancers emerge from many different paths. One path begins early, in embryonic development, when a protein complex called PRC2, which regulates cell differentiation, identity, and plasticity, becomes dysfunctional.

16 Mar 2026

Unexpected SRC Localization Offers Promising Target for Cancer Therapies

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.

16 Mar 2026

New Method Reveals How Tumors Rewire Genetic Splicing Programs

Cancer is caused by faulty genes, but what also shapes a cancer cell's behaviour is how a gene's instructions are trimmed and rearranged before they are turned into the proteins that keep a cell alive.

13 Mar 2026

Comprehensive Brain Atlas Maps Epigenetic Changes During Aging

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years.

13 Mar 2026

Dual Mechanism of Deep-Sea Sponge Compound Suppresses Cancer Cell Proliferation

A collaborative research team led by Professor Kaori Sakurai at Tokyo University of Agriculture and Technology, together with Associate Professor Hiroaki Itoh and Professor Masayuki Inoue at Graduate School of Pharmaceutical Sciences, the University of Tokyo, has uncovered a previously unknown mechanism of action of yaku'amide B, a structurally complex peptidic natural product derived from deep-sea sponge found in the waters near Yakushima Island, Japan.

12 Mar 2026

Study Reveals How Altering Cancer’s Protein Machinery Stimulates Antitumor Immunity

A new study led by Pierre Close's team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response.

12 Mar 2026

Computational Tool Improves Detection of Microbes in Tumor Sequencing Data

When scientists sequence tumor DNA, they typically find small amounts of genetic code from bacteria, viruses and fungi – microorganisms that, if actually present in tumor tissues, could influence how they grow, evade immunity or respond to treatment.

11 Mar 2026

Genetic Analysis Uncovers Shared Biology Across Major Psychiatric Conditions

Although mental disorders have multifactorial causes, genetics can explain some of them, yet this field remains largely unexplored in terms of guiding diagnoses and treatments.

10 Mar 2026

Advanced Genome Sequencing Reveals Hidden Genetic Variants Linked to Autism

Researchers at the University of California San Diego have identified new genetic variants associated with autism spectrum disorder (ASD) by using long-read whole genome sequencing (LR-WGS), an emerging approach that reads large sections of the genome at once, making it easier for scientists to find new genetic variants and understand how genetic variants affect the function of a gene.

10 Mar 2026

Discovery of Nuclear Metabolic Fingerprints Offers New Insights Into Cancer

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study published today in Nature Communications.

9 Mar 2026

Specialized Tanycyte Brain Cells Found to Play Key Role in Tau Clearance

Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau.

6 Mar 2026

AstroID Database Organizes Billions of Cancer Cells Into Searchable Hierarchical Tiers

Researchers from the Johns Hopkins Kimmel Cancer Center and The Johns Hopkins University have created a novel database structure that allows investigators anywhere to more easily study multiple types of cancer data - including laboratory results, genetic sequencing and imaging data - in one setting.

5 Mar 2026

Study Connects Gut Bacteria Patterns With Dyslipidemia Risk

Before the onset of cardiovascular disease symptoms, people often develop dyslipidemia, or abnormal levels of lipids in the blood.

5 Mar 2026

Blood Tau217 Test Predicts When Alzheimer’s Symptoms May Begin

The %p-tau217 biomarker in blood offers a novel approach to estimate Alzheimer's onset, potentially transforming prevention trial strategies.

5 Mar 2026

Bacteria-Powered Drug Discovery: A Greener Path to Curing "Undruggable" Cancers

Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilize, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.

4 Mar 2026

Tirzepatide Reduces Alcohol Drinking And Relapse In Preclinical Study

Tirzepatide alters brain reward signaling and reduces alcohol intake in rodents, indicating its potential as a therapeutic option for alcohol use disorder.

4 Mar 2026

Macrophages Offer a Safer Alternative to CAR-T Therapies with Lower Toxicity

A new study from researchers at Wake Forest University School of Medicine has identified a promising strategy to treat brain metastases, one of the most challenging and deadly complications of lung cancer.

3 Mar 2026