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Microglia Replacement Therapy Offers Hope for Genetic Disorders Affecting the Brain

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.

7 Aug 2025

New Computational Tool Reveals How Long Non-Coding RNAs Control Gene Expression

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed.

6 Aug 2025

Case Western Researchers Use Stem Cells to “Shut Off” Nerve Cell Strain

Amyotrophic lateral sclerosis (ALS), sometimes known as Lou Gehrig’s disease, is an incurable neurological disease that affects motor neurons, which are nerve cells in the brain and spinal cord that regulate voluntary muscle movement and breathing.

6 Aug 2025

CD276 Antibody Strategy Offers Hope For Immune-Resistant Lung Tumors

The study highlights 8H8_SDIE's role in activating NK cells against NSCLC, offering a new strategy for patients resistant to conventional immunotherapies.

6 Aug 2025

UCLA Researchers Reprogram Stem Cells to Produce Continuous Cancer-Fighting T Cells

In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents.

5 Aug 2025

Gut Bacteria Breakthrough Could Help Fight Chronic Diseases

An international research team led by scientists from the University of Copenhagen has discovered a common gut bacterium that lowers body weight and blood sugar while increasing bone density.

1 Aug 2025

Cancer Cells Trigger Instant Energy Surge When Squeezed

Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications.

31 Jul 2025

PD-1 Guides T Cells to Become Long-Term Immune Defenders in the Skin

Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.

30 Jul 2025

AI-Designed Proteins Offer New Hope for Personalized Cancer Immunotherapy

Precision cancer treatment on a larger scale is moving closer after researchers have developed an AI platform that can tailor protein components and arm the patient's immune cells to fight cancer.

29 Jul 2025

Discovery of New Mitophagy Trigger Offers Hope for Parkinson’s Disease

Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest study, leading cell biologists at the Max Perutz Labs at the University of Vienna investigated mitophagy – a form of autophagy – and came to a remarkable conclusion: the researchers have described a new trigger for mitophagy.

29 Jul 2025

Multi-Omics Approaches Reveal New Insights into Colorectal Cancer Liver Metastasis

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

29 Jul 2025

Study Uncovers Genetic Roots of Stuttering

The largest genetic analysis of stuttering has demonstrated a clear genetic basis for the speech disorder, highlighting neurological pathways of risk.

29 Jul 2025

Misfolded Proteins in Mitochondria Linked to Type 2 Diabetes

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

23 Jul 2025

OHSU Team Identifies Gene Essential for Brain's Protective Layer

Researchers at Oregon Health & Science University have discovered a gene that is critical to the brain’s ability to form myelin, a protective layer around nerves, potentially leading to new treatments for an extremely uncommon childhood disorder and more common diseases such as multiple sclerosis.

23 Jul 2025

Gene Editing Reverses Symptoms of Rare Brain Disorder in Mice

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

22 Jul 2025

mRNA Vaccine Supercharges Immunotherapy Against Cancer

An experimental mRNA vaccine improved the tumor-fighting benefits of immunotherapy in a mouse model study, bringing researchers one step closer to their aim of generating a universal vaccination to “wake up” the immune system against cancer.

21 Jul 2025

Molecular Chatter Between Cells Drives Tumor Growth and Immune Suppression

A Ludwig Cancer Research study has identified a complex chain of molecular chatter by which cancer cells, exploiting ordinary metabolic processes, program one set of noncancerous cells to manipulate another set of such cells to support their growth and survival.

18 Jul 2025