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Enzyme BVRA Found to Shield Neurons from Oxidative Stress

New research from Johns Hopkins Medicine shows that the enzyme biliverdin reductase A (BVRA) plays a direct protective role against oxidative stress in neurons, independent of its role producing the yellow pigment bilirubin.

4 Nov 2025

Reactivating a Naturally Occurring Gene Promotes Heart Repair and Regeneration

A naturally occurring gene called Cyclin A2 (CCNA2), which turns off after birth in humans, can actually make new, functioning heart cells and help the heart repair itself from injury including a heart attack or heart failure when the gene is turned back on.

4 Nov 2025

Intracellular Compounds Offer Blueprint for Next-Generation Targeted Therapies

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

3 Nov 2025

TRF1 Knockout Mice Exhibit Healthier Metabolic States Without Telomere Shortening

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled "Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles."

28 Oct 2025

Understanding Interplay of Physiological Processes as the Brain Shifts from Wakefulness to Sleep

Findings from Mass General Brigham investigators highlight the intricate interplay of diverse physiological processes as the brain shifts from wakefulness to sleep.

27 Oct 2025

Study Shows Flatulence Gas Hydrogen is Crucial for Gut Health

Farts are causing a stink in the research world, but in a positive way.

24 Oct 2025

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Ingestible Bioprinter Revolutionizes Possibilities for Non-Invasive Tissue Repair

The MEDS device enables non-invasive tissue repair in the GI tract, utilizing innovative bioprinting techniques for effective treatment of internal lesions.

23 Oct 2025

Serotonin-Producing Gut Microbes May Hold the Key to Treating IBS

Research from the University of Gothenburg, Sweden, clarifies the complex interaction between gut bacteria and IBS.

21 Oct 2025

Autophagy Protein ATG9A Shields the Skin from Harmful Inflammation

Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation.

21 Oct 2025

Leptin-Sensitive Brain Circuit Helps Overcome Anxiety to Perform Essential Behaviors

How do mammals manage to eat in situations that cause anxiety, step into exposed spaces, or slow down when anxiety drives them to keep moving? A new study pinpoints a leptin-sensitive circuit in the lateral hypothalamus that helps to overcome anxiety to perform essential behaviors such as exploring, feeding, and limiting maladaptive hyperactivity.

21 Oct 2025

Revolutionary Technique Produces Trillions of Healthy Endothelial Cells

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

15 Oct 2025

Breakthrough in Lab-Grown Blood Stem Cells Using Self-Organizing Embryo Models

University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development - including the production of blood stem cells.

14 Oct 2025

St. Jude Researchers Uncover Dual Role of ASPL in Stress Granule Assembly and Disassembly

Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked to neurodegenerative diseases.

10 Oct 2025

RyR1-Mediated CICR Plays Minimal Role in Normal Skeletal Muscle Contraction

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

26 Sep 2025

RION Engages Lonza to Scale Manufacturing Exosome Based Therapeutics

RION, a commercial and clinical-stage regenerative medicine company pioneering platelet-derived exosomes for both human and animal health applications, has announced a collaboration with Lonza, one of the world’s largest contract development and manufacturing organizations (CDMOs), to provide cGMP manufacturing and technical support for commercial scale production of its Purified Exosome Product™ (PEP™) drug substance for late phase clinical supply and beyond.

From Lonza 26 Sep 2025