Genetics and Genomics News and Research

Latest Genetics and Genomics News and Research

Metabolic Pathway Loss Makes Cancer Cells Vulnerable to PARP Drugs

Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their vulnerability to a class of anticancer drugs known as PARP inhibitors, a study led by UT Southwestern Medical Center researchers shows.

5 May 2026

New Model Explains How Genetic Information Maintains Cellular Order

A Moffitt Cancer Center researcher has introduced a new model that addresses one of biology's most fundamental questions: How does genetic information keep living systems organized and therefore alive?

5 May 2026

Engineered Bacteriophage Speeds up the "Training" of Plastic-Eating Bacteria

Millions of tons of plastic waste build up in landfills and oceans each year. One promising approach is to engineer microbes to break plastic down into useful chemical building blocks.

4 May 2026

Genomic Tool TRACS Improves Tracking of Microbial Transmission Patterns

The research, published today (24 April) in Nature Microbiology, describes how the new tool, called TRAnsmision Clustering of Strains (TRACS), uses genomics to distinguish between closely related bacterial strains.

4 May 2026

Host Genetics and Sex Shape Evolution of Viral Virulence

During the early stages of a pandemic, viruses tend to evolve in ways that enhance their ability to reproduce and spread, rather than to evade the host's immune system.

4 May 2026

Building a Large-Scale Atlas of Female Reproductive System Aging

Despite affecting half of the world's population, menopause has historically been understudied and misunderstood, both in biomedical research and clinical practice.

30 Apr 2026

Accelerating Enzyme Discovery With the SMART Single-Molecule Screening System

Enzymes are proteins that catalyze chemical reactions in living organisms. They are widely applied in industries such as food production, detergents, pharmaceuticals, and chemicals.

30 Apr 2026

Pronuclei Size Competition Maintains Gene Regulation in Early Embryos

The sperm and the egg cell's nuclei compete for size directly after fertilization and this is necessary for the proper embryonic development.

30 Apr 2026

AI Reveals Dynamic DNA Accessibility Within Nucleosome Structures

Every cell in the human body squeezes over six feet of DNA into a miniscule speck invisible to the naked eye-like compressing a whole house into a single sugar cube.

30 Apr 2026

Stage-Dependent Gene Expression Changes Reveal Cellular Aging Dynamics

A new research paper was published in Volume 18 of Aging-US on April 10, 2026, titled "Stage-dependent transcriptomic changes in human dermal fibroblast senescence model."

30 Apr 2026

Prime Assembly Approach Transforms Gene Therapy With Large DNA Inserts

New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment from cancellation of disease-causing mutations to replacement of an entire gene, scientists say.

30 Apr 2026

Long Read Sequencing Uncovers Telomere Length Variation Across Chromosomes

In a new proof-of-concept study published in Nature Communications, researchers at the University of Chicago analyzed genomic data from more than 2,500 participants in the national All of Us research program to estimate chromosome-specific telomere length (csTL).

30 Apr 2026

How the Microbiome Shapes Cancer Immunity and Therapy Response

This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.

29 Apr 2026

New Pipeline Sharpens Single-Cell Profiling of CAR Immune Therapies

CERTOMICS is a Nextflow-based computational pipeline designed to identify and profile CAR-engineered immune cells using single-cell multiomics data. By integrating gene expression, immune receptor profiling, protein markers, CAR-aware references, and CAR-specific quality control, it supports more standardized analysis of adoptive cellular immunotherapies.

29 Apr 2026

Intermediate PRRX1 Levels Drive Breast Cancer Metastasis Risk

The study identifies PRRX1 as a critical factor in breast cancer metastasis, highlighting its potential as a biomarker for predicting aggressive disease.

29 Apr 2026

Drug Development: Development of Dextran Nanoparticles for Stabilizing Delicate Proteins

Nanoscale Research Letters, an open access journal published under Springer Open, presented a study entitled "Development of Dextran Nanoparticles for Stabilizing Delicate Proteins." In this study, a Brookhaven NanoBrook 90Plus Particle Size Analyzer was used to help develop a novel approach to stabilize and encapsulate proteins into dextran nanoparticles.

From Brookhaven Instruments 29 Apr 2026

MD Anderson Researchers Map DNA Replication Stress at Single-Cell Resolution

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with single-cell resolution.

28 Apr 2026

High Resolution Images Reveal DNA Repair Process in Key Protein

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

28 Apr 2026

Protein Adgrl2 Regulates Brain Synapses and Blood Vessel Integrity

The communication network in the developing brain builds when neurons partner up to form contact points called synapses, allowing signals to pass form one cell to another.

28 Apr 2026

Obesity Leaves Persistent Epigenetic Marks on Immune Cells

People who live with obesity are 'tagging' a memory of being overweight on a key part of the immune system - leaving people with ongoing risk of obesity-related conditions years after losing weight, according to a 10 year-long study published in EMBO Reports.

28 Apr 2026