Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Copper-binding protein influences migration of breast cancer cells

Copper-binding protein influences migration of breast cancer cells

At the Chalmers University of Technology, scientists have demonstrated that the Atox1 protein, which is highly concentrated in breast cancer cells, takes part in a process—the process through which cancer cells spread.

11 Mar 2020

Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

At the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, scientists have investigated how solute carriers (SLCs)—a large class of membrane transport proteins—affect the activity and potency of cytotoxic drugs, for example, those used to treat leukemia and other cancers.

10 Mar 2020

New study on viruses could help design engineered nano-shells used in drug delivery

New study on viruses could help design engineered nano-shells used in drug delivery

Viruses are small disease-causing parasites with the potential to infect all life forms. Although they have been analyzed well, there still exist several mysteries.

10 Mar 2020

New chromosome-level detectors developed to monitor cellular activity

New chromosome-level detectors developed to monitor cellular activity

For researchers investigating the regulatory processes in cells that are vital to all life, an innovative system that amplifies gene expression signals could be a turning point.

10 Mar 2020

Research sheds light on why some invasive plants gain a headstart after fire

Research sheds light on why some invasive plants gain a headstart after fire

New research from The University of Western Australia has shed light on why some invasive plants make a better comeback after a fire, outstripping native species in the race for resources.

From The University of Western Australia 9 Mar 2020

New discovery reveals earliest known instance of complex form of protein regulation

New discovery reveals earliest known instance of complex form of protein regulation

Researchers have given a new life to the ancient history of two proteins, thus gaining insights into the origin of an age-old molecular partnership.

9 Mar 2020

A new breakthrough could lead to better approaches for preventing breast cancer metastasis

A new breakthrough could lead to better approaches for preventing breast cancer metastasis

New breakthrough in breast cancer could enable the development of better approaches to prevent the spread of cancer cells to other organs in the body, thereby effectively bringing down mortality in patients suffering from breast cancer.

9 Mar 2020

Researchers successfully crystallize and map novel conformation of LeuT transporter

Researchers successfully crystallize and map novel conformation of LeuT transporter

Researchers at the University of Copenhagen have mapped a novel structure of what is called a “neurotransmitter: sodium symporter.”

9 Mar 2020

Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding

Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding

An international team of researchers has disproved the role of an essential protein, known as Oct4, in regulating gene expression.

22 Feb 2020

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

A team of scientists has discovered that the WDR74 protein plays a vital role in metastasis progression in lung cancer and melanoma primary tumors.

22 Feb 2020

New correlative, 3D, super resolution imaging platform reveals unexpected findings in mammalian cells

New correlative, 3D, super resolution imaging platform reveals unexpected findings in mammalian cells

Researchers have developed a platform for the 3D super-resolution imaging at the nanoscale level that has revealed unexpected findings in mammalian cells.

21 Feb 2020

Distinct loss-of-function variants cause shared clinical features in neuronal development disorders

Distinct loss-of-function variants cause shared clinical features in neuronal development disorders

Researchers have shown that mutations in four distinct genes that lead to Kleefstra syndrome.

20 Feb 2020

Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies

Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies

A team in Massachusetts has established a method of profiling of mispairing in antibody assembly.

18 Feb 2020

Combining AIMS with machine learning to speed up breast cancer diagnosis

Combining AIMS with machine learning to speed up breast cancer diagnosis

Researchers have conducted a study showing that combining an AIMS approach with machine learning could speed up the diagnosis of breast cancer.

15 Feb 2020

Mass spectrometry analyzing ozonolysis of triacylglycerols determines fingerprint age

Mass spectrometry analyzing ozonolysis of triacylglycerols determines fingerprint age

Researchers have established a way to determine the age of fingerprints that could help forensic investigators.

14 Feb 2020

Applying integrated lipidomics and proteomics in multiple myeloma reveals potential disease pathways

Applying integrated lipidomics and proteomics in multiple myeloma reveals potential disease pathways

A team of Australian researchers has confirmed the feasibility and potential of applying integrated lipidomics and proteomics to malignant plasma cells from myeloma patients.

13 Feb 2020

A new study finds a potential immunotherapeutic pan-target on cancer cells

A new study finds a potential immunotherapeutic pan-target on cancer cells

In a genome-wide CRISPR-Cas9 screen published in Nature Immunology in January 2020, a group of researchers described a potential universal target on cancer cells.

12 Feb 2020

Clinical lipidomics in understanding of lung cancer: Opportunity and challenge

Clinical lipidomics in understanding of lung cancer: Opportunity and challenge

A team of scientists has recently outlined the need to develop and standardize lipidomic measurements and baseline figures.

11 Feb 2020

Lipidomics of human adipose tissue reveals diversity between body areas

Lipidomics of human adipose tissue reveals diversity between body areas

Scientists have established a lipidomic method that proved successful in the analysis of human subcutaneous adipose biopsies.

11 Feb 2020

Progesterone induces sperm release from oviductal epithelial cells by modifying sperm proteomics

Progesterone induces sperm release from oviductal epithelial cells by modifying sperm proteomics

An international team of researchers has uncovered valuable insights on the underlying mechanisms involved in the process of sperm release from the oviduct.

10 Feb 2020