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Single-Cell RNA Sequencing Sheds Light on Craniopharyngioma Tumor Subtypes

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary.

17 Dec 2024

Stem Cell-Derived Brain Organoids Model Mitochondrial Diseases

Mini-brains, also known as brain organoids, have been created by researchers at the University of Bergen using cutting-edge stem cell technology.

16 Dec 2024

Study Reveals Mechanism Behind T Cells' Cancer-Killing Power in Hypoxia

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective.

16 Dec 2024

Researchers Uncover Lamin A's Role in DNA Repair and Premature Aging Disease

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

16 Dec 2024

AI Creates the First Virtual Human Cell

A team of scientists from Stanford University, Genentech, and the Chan-Zuckerberg Initiative claims that science has an “unprecedented opportunity” to use artificial intelligence (AI) to create the first virtual human cell in history, pointing out that recent advancements in AI and the availability of extensive experimental data about human biology have reached a critical mass.

13 Dec 2024

A breakthrough in muscle cell regeneration and alignment with ultrasonic vibrations.

This study explores the use of ultrasonication to align and enhance the differentiation of myotubes, providing a non-invasive, scalable approach for tissue engineering and regenerative medicine.

13 Dec 2024

Discovery of 18-Digit Code Unlocks Exosome-Based Drug Delivery

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to attach themselves to exosomes - tiny pinched-off pieces of cells that travel around the body and deliver biochemical signals.

12 Dec 2024

Advancements in Cell-Penetrating Antibodies Open New Avenues in Cancer Therapy

A news feature on the research paper "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition" by Rackear et al. was published in Oncotarget's Volume 15 on November 22, 2024, titled "Advancements in cell-penetrating monoclonal antibody treatment."

12 Dec 2024

Programmable G-protein-coupled receptors redefine therapeutic applications.

This study demonstrates the development of PAGERs (programmable antigen-gated engineered receptors), combining antigen specificity, modular adaptability, and drug-controlled activation, with potential applications in synthetic biology, therapeutics, and neuroscience.

12 Dec 2024

Biomaterials to Regenerate the Nervous System: Carl Zeiss Foundation Sponsors InteReg Project at Mainz University

Collaborative project involving Johannes Gutenberg University Mainz, the Max Planck Institute for Polymer Research, and the Leibniz Institute for Resilience Research will receive EUR 6 million.

11 Dec 2024

Study Reveals How Toxoplasma Parasite Evades Drug Treatment by Altering Protein Production

A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

10 Dec 2024

Insights into Neurodegenerative Diseases and Pest Control

Key gene regulators that allow certain deafened animals, such as fish and lizards, to naturally regenerate their hearing have been identified by a recent USC Stem Cell study that was published in the journal Proceedings of the National Academy of Sciences (PNAS).

10 Dec 2024

New Era of Combined mRNA and RNAi Therapies

Researchers at the University of Ottawa have figured out how to use mRNA and RNAI-based treatments to treat complex illnesses like cancer and heart disease.

10 Dec 2024

Brazilian Study Offers Fresh Perspectives on Pancreatic Cancer Genetics

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

New Study Challenges Traditional View of Axon Shape and Function

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

9 Dec 2024

Novel Approach to Monitor ER-Related Protein Quality Control

Protein synthesis in eukaryotic cells found in plants, animals, and fungi involves more than just the straightforward ribosome assembly of amino acids.

9 Dec 2024

"Molecular GPS" Developed to Guide Immune Cells into the Brain and Kill Tumors

Researchers have found a way to program immune cells to attack glioblastoma and treat the inflammation of multiple sclerosis in mice.

6 Dec 2024

Key Enzymes Identified as Regulators of Cancer Cell Nutrient Foraging

Cancer cells are like booming cities without urban planners. They expand quickly, and in doing so, the resulting tumors consume more energy and other resources than they can acquire from nearby blood vessels.

6 Dec 2024

Adult Neurogenesis Found to Aid Verbal Learning and Memory

Why do adults make new brain cells? A new study published in Cell Stem Cell provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear.

6 Dec 2024

Biobank Data can Provide Insights into Genetic Architecture of Drug Response

A UCLA study has outlined a new framework that researchers say would improve predictive power of genetics to determine how well a patient would respond to commonly prescribed medications as well as the severity of any side effects.

5 Dec 2024