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Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Research headed by Professor Xiujun Cai used the CRISPR/cas9 system to screen the entire genome of hepatocellular carcinoma cells (HepG2) under sorafenib treatment.

25 Apr 2022

Releasing Wolbachia-infected mosquitoes to protect the global community from dengue

Dengue is the most widespread mosquito-borne disease in the world, and to date, there are no medical treatments for people suffering from this disease.

21 Apr 2022

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Scientists reveal the origins and provide a detailed ID card of pancreatic endocrine stem cells

The pancreas is a key metabolic regulator. When pancreatic beta cells cease producing enough insulin, blood sugar levels rise dangerously — a phenomenon known as hyperglycemia — thus triggering diabetes.

20 Apr 2022

Stem cell-mediated gene therapy technique helps to boost bone regeneration

Mesenchymal stem cell-derived exosomes (MSC-Exo) have gained a lot of attention due to their “cell-free” treatments.

20 Apr 2022

Researchers analyze the complex function of cyanobacteria and the regulation of the biological clock

Researchers aim to learn more about circadian rhythms, which are the 24-hour internal clock cycles of sleeping and waking that happens in all species, including humans, plants, fungi, and bacteria.

18 Apr 2022

Immune cell migration contributes to inefficient antitumor immunity, study finds

Mutations in the APC gene cause the production of intestinal polyps in persons suffering from familial adenomatous polyposis, a genetic disease that predisposes them to colon cancer.

From Institut Pasteur 15 Apr 2022

Max Planck researchers reveal the structure of kinetochore corona

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

From The Max Planck Institute 11 Apr 2022

New scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes

A Mount Sinai-led team has developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)-;cells that support heart muscle contraction, generated in the lab from human stem cell lines-;which researchers say will improve approaches for disease modeling, regenerative therapies, and drug testing.

8 Apr 2022

Primordial germ cell-like cells produced from stem cells undergo gametogenesis to yield normal offspring

Primordial germ cell-like cells (PGCLCs), generated in vitro from the stem cells of rats, undergo gametogenesis in vivo and yield normal rat offspring, a new study demonstrates.

8 Apr 2022

Cell Guidance Systems and Manchester BIOGEL collaborate to launch PODS-PeptiGels for 3D cell culture

Cell Guidance Systems Ltd today announced a collaboration to launch PODS®-PeptiGels®.

From Cell Guidance Systems 5 Apr 2022

Using a microfluidic chip for selection of healthy sperm based on positive rheotaxis

The female genital tract can be a hostile environment for conception. Out of about 100 million sperm, only a few hundred make it to the fallopian tubes.

1 Apr 2022

New BGI research lays groundwork for organ regeneration

Scientists declared the invention of a transgene-free and manageable method to transform pluripotent stem cells into bona fide 8-cell totipotent embryo-like cells.

23 Mar 2022

Residual coffee grounds could help detect small levels of neurotransmitters

There's nothing like a steaming cup of joe to give your morning a quick boost. Now, there's yet another reason to love the beverage.

21 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

One-step ELISA experiments

AMSBIO announces the launch of the QuicKey Pro™ range of ELISA kits – new easy-to-use assays that require just one step of washing, and one step of sample addition, resulting in a whole experiment taking only 90 minutes.

15 Mar 2022

The Nucleic Acid Experts – Certified Twice!

BioEcho Life Sciences receives two important hallmarks for its quality management – DIN EN ISO 9001:2015 and DIN EN ISO 13485:2016.

From BioEcho Life Sciences GmbH 10 Mar 2022

Multi-omics approach help researchers study the disparity created by in vitro culture

Citrus is a significant and economically beneficial horticultural crop with nucellar polyembryony, which prevents hybrid offspring from being produced. Citrus is produced mostly through asexual methods like grafting and cuttings.

7 Mar 2022

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Researchers optimize a route for two-step synthesis of antiviral plant protectant

Plant viruses are of great variety and harm. Virus disease pandemics and epidemics were estimated to have a global economic impact in the tens of billions of dollars.

3 Mar 2022

in vitro News and Research

Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Releasing Wolbachia-infected mosquitoes to protect the global community from dengue

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

Scientists reveal the origins and provide a detailed ID card of pancreatic endocrine stem cells

Stem cell-mediated gene therapy technique helps to boost bone regeneration

Researchers analyze the complex function of cyanobacteria and the regulation of the biological clock

Immune cell migration contributes to inefficient antitumor immunity, study finds

Max Planck researchers reveal the structure of kinetochore corona

New scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes

Primordial germ cell-like cells produced from stem cells undergo gametogenesis to yield normal offspring

Cell Guidance Systems and Manchester BIOGEL collaborate to launch PODS-PeptiGels for 3D cell culture

Using a microfluidic chip for selection of healthy sperm based on positive rheotaxis

New BGI research lays groundwork for organ regeneration

Residual coffee grounds could help detect small levels of neurotransmitters

New database provides extensive information on kinase-associated neural protein phosphorylation

One-step ELISA experiments

The Nucleic Acid Experts – Certified Twice!

Multi-omics approach help researchers study the disparity created by in vitro culture

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers optimize a route for two-step synthesis of antiviral plant protectant

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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