Cancer News and Research

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Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

CRISPR Reveals Dark Genome Regions That Sense Cellular Mechanics

Researchers at Duke University used CRISPR technologies to discover previously unannotated stretches of DNA in the 'dark genome' that are responsible for controlling how cells sense and respond to the mechanical properties of their local environment.

12 Dec 2025

Comprehensive Gene Maps Reveal Hidden Networks Behind Disease Traits

Today's biomedical researchers are relentlessly searching for genes that drive disease, with the goal of creating therapies that target those genes to restore health.

12 Dec 2025

Visualizing How Cancer Seed Cells Evade Brain Immunity

Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death. Brain metastasis is particularly severe and affects 10-30% of patients with advanced lung, breast, and melanoma cancers.

12 Dec 2025

Mitochondrial Supercomplex Protein COX7RP Extends Lifespan and Healthspan

As life expectancy continues to climb globally, the focus of many people has moved from longevity alone to living in good health.

11 Dec 2025

Researchers Elucidate Microtubule-Mediated Cell Signal Transduction

The most diverse functions of a cell in the human body – from cell division and differentiation to motility and programmed cell death – are controlled by signaling proteins within the cell. This includes the immune system and the reading of genetic information.

11 Dec 2025

AI-Driven Method Uncovers Hidden Cancer Drivers

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

11 Dec 2025

OIST Study Illuminates Cancer's Avoidance of Cellular Stress Responses

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

11 Dec 2025

Scientists Discover First Human DNA-Cutting Enzyme That Responds to Tension

An international research team at the University of Hong Kong has discovered a human protein known as ANKLE1, which is recognized as the first DNA-cutting enzyme (nuclease) in mammals that can detect and respond to physical tension in DNA.

10 Dec 2025

Breaking the Interspecies Immune Barrier to Advance Human Organ Generation

Failure of human pluripotent stem cells (PSCs) to survive when grown with the PSCs of distantly related species occurs because of an innate immune reaction in the nonhuman cells, a study led by UT Southwestern Medical Center researchers suggests.

9 Dec 2025

How Tumor Stem Cells Hijack Neutrophils to Evade Immunotherapy

Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors.

9 Dec 2025

Protein ‘Neighborhood’ Holds an ABC Transporter in Place to Regulate Cyclic AMP Signaling

When a cell receives a message from outside, it generates a molecule called cyclic AMP (cAMP) to relay this message. To ensure the signal reaches the correct effector without triggering pathways accidentally, cAMP levels must be maintained around their point of origin and at the right level.

8 Dec 2025

New Tunable Device Enables Precise Size-Based Sorting of Cancer Cells

Poly(N-isopropylacrylamide) (PNIPAM) hydrogel undergoes significant but precise changes in size between 20 and 40 °C, making it an excellent candidate for use in variable-size deterministic lateral displacement (DLD) array devices.

8 Dec 2025

Spatial Touchstone Project Brings Standardization to Spatial Transcriptomics

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located.

8 Dec 2025

Broken DNA Loops Trigger Lymphoma Development

Cancer involves more than just genetic mutations; it also involves structural failures. Consider a city where roads disappear, isolating communities from vital resources.

8 Dec 2025

Researchers Capture the Most Detailed Images of Molecules in Chromatin Condensates

A team of researchers led by HHMI Investigator Michael Rosen has captured the most detailed images yet of the molecules in chromatin condensates — droplet-like structures of compacted DNA.

5 Dec 2025

Senescent Fibroblasts in the Tumor Niche Rewire Lung Cancer Metabolism and Plasticity

Senescent fibroblasts are aging cells that no longer divide and protect against tumor development. Yet two decades have gone by since cell biologist Judith Campisi, PhD, paradoxically demonstrated that these same cells can promote cancer growth in a laboratory setting.

5 Dec 2025

PLAMseq Revolutionizes Simultaneous Analysis of Genome Proteins and Their Locations

A team from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labelled affinity-purified mass spectrometry plus sequencing) that, for the first time, allows simultaneous analysis of chromatin-associated proteins and their location in the genome in a single experiment.

5 Dec 2025

New Tool Predicts Which Intrinsically Disordered Regions Drive Condensate Formation

Fusion oncoproteins arise when a gene fuses with another gene and acquires new abilities. Such abilities can include the formation of biomolecular condensates, "droplets" of concentrated proteins, DNA or RNA.

4 Dec 2025

Circular Single-Stranded DNA Molecule Can Simultaneously Silence Multiple MicroRNAs

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen Dong of the Institute of Chemistry, Chinese Academy of Sciences, have collaborated to develop a circular single-stranded DNA molecule capable of simultaneously silencing multiple miRNAs.

4 Dec 2025

Benchmarking DNA Language Models for Precision Genomics

Researchers at The University of Texas MD Anderson Cancer Center have performed a comprehensive evaluation of five artificial intelligence (AI) models trained on genomic sequences, known as DNA foundation language models.

4 Dec 2025

Cancer News and Research

CRISPR Reveals Dark Genome Regions That Sense Cellular Mechanics

Comprehensive Gene Maps Reveal Hidden Networks Behind Disease Traits

Visualizing How Cancer Seed Cells Evade Brain Immunity

Mitochondrial Supercomplex Protein COX7RP Extends Lifespan and Healthspan

Researchers Elucidate Microtubule-Mediated Cell Signal Transduction

AI-Driven Method Uncovers Hidden Cancer Drivers

OIST Study Illuminates Cancer's Avoidance of Cellular Stress Responses

Scientists Discover First Human DNA-Cutting Enzyme That Responds to Tension

Breaking the Interspecies Immune Barrier to Advance Human Organ Generation

How Tumor Stem Cells Hijack Neutrophils to Evade Immunotherapy

Protein ‘Neighborhood’ Holds an ABC Transporter in Place to Regulate Cyclic AMP Signaling

New Tunable Device Enables Precise Size-Based Sorting of Cancer Cells

Spatial Touchstone Project Brings Standardization to Spatial Transcriptomics

Broken DNA Loops Trigger Lymphoma Development

Researchers Capture the Most Detailed Images of Molecules in Chromatin Condensates

Senescent Fibroblasts in the Tumor Niche Rewire Lung Cancer Metabolism and Plasticity

PLAMseq Revolutionizes Simultaneous Analysis of Genome Proteins and Their Locations

New Tool Predicts Which Intrinsically Disordered Regions Drive Condensate Formation

Circular Single-Stranded DNA Molecule Can Simultaneously Silence Multiple MicroRNAs

Benchmarking DNA Language Models for Precision Genomics

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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