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Newly Discovered CRISPR System Activates Genes Without Cutting DNA

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA.

26 Mar 2026

SLIT3 Protein Drives Brown Fat Activation Through Dual Signaling

Researchers have determined how a key protein activates brown fat by expanding blood vessels and nerves in the heat-generating tissue.

26 Mar 2026

New Skin Atlas Reveals Cellular Diversity Across Body Sites

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body.

26 Mar 2026

Reversing Memory Loss in Aging Mice by Targeting Gut Bacteria

The study uncovers how gut bacteria like Parabacteroides goldsteinii contribute to memory decline, offering insights for potential cognitive interventions.

26 Mar 2026

Synthetic Plasmid Design Enables Precise Control of DNA Replication

"If it ain't broke, don't fix it," goes the old adage, which Rice University professor James Chappell completely ignored in a recent Nature Communications publication.

26 Mar 2026

Where Digital Holographic Microscopy Complements Fluorescence Microscopy

Integrating Digital Holographic Microscopy with fluorescence techniques enhances live-cell imaging, preserving cellular integrity and improving assay accuracy.

From Park Systems 25 Mar 2026

NAC Complex Triggers Protein Folding at Earliest Stage of Synthesis

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps towards folding proteins into their correct three-dimensional structures.

24 Mar 2026

New PanNDA Atlas Maps Protein Networks in Neurodegenerative Diseases

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA).

24 Mar 2026

Scientists Map Gene Sharing Networks in Wastewater Treatment Biofilms

Wastewater treatment systems are hotspots for mobile genetic elements proliferation and exchange, where dense biofilms create ideal conditions for horizontal gene transfer.

24 Mar 2026

Study Highlights Hidden Protist Diversity Through Single-Cell Genomics

Researchers from the Earlham Institute, in collaboration with The Department of Biology at the University of Oxford, discovered three previously unrecognised lineages of the protist Bodo, each with its own bacterial endosymbiont (a symbiotic organism living within the body of its host).

23 Mar 2026

New Mechanism Links Mitochondria Dysfunction to T Cell Exhaustion

The immune system's killer T cells do a commendable job of detecting and destroying cancer cells. But the harsh environment at the heart of tumors often saps them of their vitality, pushing them into a state of permanent lassitude called "terminal exhaustion."

23 Mar 2026

How Toxic Protein Spreads in Huntington’s Disease

Huntington's disease is a debilitating brain disorder that gradually robs people of mobility, memory, and personality.

23 Mar 2026

New Enzyme Atlas Rewrites Decades of Biology Research

WEHI researchers have led a major global effort to create the first authoritative atlas for a class of enzymes that regulate almost every cellular process in the human body.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 23 Mar 2026

Mice Study Reveals Cholecystokinin as Key Driver of Obesity-Related Pancreatic Cancer

Obesity increases the body's need for insulin, forcing cells in the pancreas known as beta cells to ramp up insulin production to maintain blood sugar levels.

22 Mar 2026

Scientists Develop Method to Sequence Proteins Using DNA Technology

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions.

19 Mar 2026

PAX3 Protein Plays Key Roles in Development and Cancer

Paired Box 3 (PAX3) is a protein that plays a critical role in the formation of tissues and organs during embryonic development and can positively (and less frequently, negatively) regulate gene expression.

19 Mar 2026

Molecular Switch Links Mitochondrial Stress to T Cell Exhaustion

Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed.

19 Mar 2026

New Base Editing Tool Reduces Unwanted DNA Bystander Mutations

The trajectory of base editing has been remarkable, progressing from the laboratory to patient care, treating debilitating or terminal illnesses, in less than a decade.

19 Mar 2026

New Computational Tool Streamlines Analysis of Massive Genomic Datasets

In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models or cultured cells.

19 Mar 2026

Psoriasis-Like Inflammation Limits Skin Cancer Growth

A study shows that psoriasis-like immune responses may limit skin cancer growth, challenging the view of chronic inflammation as solely tumor-promoting.

19 Mar 2026