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Genomic-First Approach Offers Potential for Earlier Diagnosis of Rare Disorders

A "genomic-first" approach to screening for rare genetic disorders -identifying specific genetic variants and then studying associated traits and symptoms - can identify these conditions earlier and more frequently than standard genetic testing driven by clinical symptoms, a Geisinger study found.

8 Oct 2025

Multiple Genetic Changes Play Key Role in the Development of Complex Disorders

The genetic roots of a disease or disorder do not always grow into clear cut, easily diagnosed clinical features.

8 Oct 2025

New Computer-Driven Strategy Reveals How Membrane Proteins Maintain Stability

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring cells stick together.

8 Oct 2025

Studies Uncover PAR2 Receptor’s Role in Gut Inflammation and Pain

Abdominal pain is common in a variety of digestive diseases, including inflammatory bowel disease and irritable bowel syndrome.

8 Oct 2025

Study Reveals Tissue-Specific DNA Patterns Used by HIV to Evade Detection

Researchers at Western University and the University of Calgary have discovered how HIV hides in different parts of the body by embedding itself into the DNA of cells in a tissue-specific manner, offering new insights into why the virus is so difficult to eliminate and cure – even decades after infection and treatment.

7 Oct 2025

Wasatch Biolabs Expands Service Portfolio with Oxford Nanopore Assays in Pharmacogenomics, Telomere Sequencing, and mRNA Vaccine Quality Control

Wasatch BioLabs (WBL), a Renew Biotechnologies subsidiary, and the largest U.S. sequencing service provider dedicated exclusively to long-read sequencing, today announced the addition of three Oxford Nanopore-developed research-use-only (RUO) assays to its service portfolio: a Pharmacogenomics (PgX) panel, Telomere Sequencing, and mRNA Vaccine Quality Control.

7 Oct 2025

EZH2 Inhibition Restores Order in Cancer Cell Division and Reduces Metastasis

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from spreading.

6 Oct 2025

New Genetic Map of Human Metabolism Reveals How Genes Influence Health and Disease

A recent study published in Nature Genetics developed the largest genetic map of human metabolism, giving new insights into the role of metabolites in health and disease and providing a framework for future research.

6 Oct 2025

Breakthrough in Understanding How Tick-Borne Encephalitis Virus Infects Human Brain Cells

The protein on human cells that tick-borne encephalitis virus (TBEV) uses for infection has now been identified-a major step toward understanding how TBEV causes neurological disease and for developing antiviral drugs.

3 Oct 2025

How GBA Mutations Drive Cognitive Decline in Parkinson's Disease

Parkinson's disease causes both movement and cognitive deficits, and for a long time both were thought to be caused by the accumulation of a protein called alpha-synuclein in the brain.

3 Oct 2025

New Synthetic Proteins Boost Efficiency of Genome Editing Tools

Researchers at Integra Therapeutics, in collaboration with the Pompeu Fabra University (UPF) Department of Medicine and Life Sciences (MELIS) and the Center for Genomic Regulation (CRG), have designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature.

3 Oct 2025

Thermo Fisher Scientific Expands Neurodegeneration Research Capabilities with Launch of Olink® Target 48 Neurodegeneration Panel

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Olink® Target 48 Neurodegeneration panel, a high-performance, targeted proteomics immunoassay panel developed to accelerate discoveries in neurodegenerative disease research.

From Olink®- Part of Thermo Fisher Scientific 3 Oct 2025

Comprehensive Proteomic Analysis with COOKIE-Pro Reveals Drug Affinity and Reactivity

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

Scientists Derive Authentic Embryonic Stem Cells From Chickens and Other Birds

Egg whites may be perfect for a health-conscious breakfast, but egg yolks turned out to be the key ingredient for cultivating bird embryonic stem cells (ESCs) in the lab.

30 Sep 2025

Molecular Innovation Behind the Origin of Type V CRISPR-Cas Systems

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage.

30 Sep 2025

New SCOPE Tool Transforms Discovery of Gene-Regulating Proteins

A new tool greatly improves scientists' ability to identify and study proteins that regulate gene activity in cells, according to research led by Weill Cornell Medicine investigators.

30 Sep 2025

RyR1-Mediated CICR Plays Minimal Role in Normal Skeletal Muscle Contraction

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

26 Sep 2025

Study Reveals How Lymphatic Cells Preserve Immune Memory

A study published today in Nature Communications describes how lymphatic endothelial cells assist in generating robust immune memory, offering new insights into how the immune system functions.

26 Sep 2025

Protein Networks Expose New Therapeutic Targets for Alzheimer's

A recent study conducted by the Icahn School of Medicine at Mount Sinai provides one of the most thorough insights to date regarding the interactions of brain cells in Alzheimer’s disease, illustrating protein networks that expose communication breakdowns and highlight potential new therapeutic avenues for treatment.

26 Sep 2025

RION Engages Lonza to Scale Manufacturing Exosome Based Therapeutics

RION, a commercial and clinical-stage regenerative medicine company pioneering platelet-derived exosomes for both human and animal health applications, has announced a collaboration with Lonza, one of the world’s largest contract development and manufacturing organizations (CDMOs), to provide cGMP manufacturing and technical support for commercial scale production of its Purified Exosome Product™ (PEP™) drug substance for late phase clinical supply and beyond.

From Lonza 26 Sep 2025