Proteostasis News and Research

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Each mammalian cell contains up to 20,000 proteins, all of which must be maintained and regulated. Proteostasis is a complex pathway that functions to maintain all of the proteins within and around a cell.

New mouse line reveals the state of proteostasis in mammalian brain for the first time

New mouse line reveals the state of proteostasis in mammalian brain for the first time

Proteins are the "tools" of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure.

20 Aug 2021

Infrared spectroscopy reveals DNA molecular processes in real time

Infrared spectroscopy reveals DNA molecular processes in real time

DNA strand breaks can play a role in the aging process. Now, with infrared spectroscopy, scientists have visualized the processes that take place at breaks.

4 May 2020

Hyperosmotic stress induces phase separation of the proteasomes

Hyperosmotic stress induces phase separation of the proteasomes

Cellular proteostasis is regulated by a crucial proteolytic machine called proteasome via selective degradation of ubiquitylated proteins.

29 Apr 2020

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