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High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells.

22 May 2026

Dental Pulp Stem Cell Subsets Triggers Rapid Cellular Senescence and Tooth Decay

With age, teeth get increasingly brittle and susceptible to damage from tooth decay, which can eventually lead to tooth loss. Teeth have an intrinsic capability to regenerate, a process which is driven by dental pulp stem cells (DPSCs) which replenish the dental pulp including the dentin-producing cells called odontoblasts.

22 May 2026

Scientists Find Key Genetic Boundary That Dictates Immune System Failure

Not all broken genes fail in the same way: some simply stop working, while others interfere with what still works.

22 May 2026

Allison Institute Platform Utilizes Spatial Profiling to Locate Protective Cellular Niches

Researchers with the James P. Allison Institute™ at The University of Texas MD Anderson Cancer Center have discovered a new gene expression signature within tumors that can help identify patients with metastatic castration-resistant prostate cancer (mCRPC) who are more likely to experience lasting benefits from combined immunotherapy treatment.

21 May 2026

Researchers Discover That Lesion Cells Fail to Recruit Surrounding Tissue Into Tumor Growth Helpers

In an unexpected finding, a new study flips on its head researchers' understanding of how precancerous pancreas lesions evolve into pancreatic cancer. The paradigm-changing discovery has tremendous implications for identifying people at higher risk of cancer or even, potentially stopping malignant transformation.

21 May 2026

How Minimal Medical Care Shifts Amazonian Villagers' Unique Gut Bacteria

Even minimal exposure to modern medicine can rapidly change the human microbiome. In a new study publishing May 20 in the Cell Press journal Cell Reports, researchers reveal that the gut microbes of remote Amazonian Indigenous communities began shifting toward patterns more commonly seen in urban, industrialized populations after only a few medical visits.

21 May 2026

Polymer Platforms Help Focus Immune Attack on Cancerous Tumors

Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but typically benefit less than 30% of patients.

21 May 2026

Scientists Synthesize Rare Sea Sponge Molecules to Boost Future Cancer Drug Development

Florida State University chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge, a breakthrough for the future of drug development, particularly for rare forms of cancer.

21 May 2026

Disrupted Honeycomb Cellular Patterns in the Early Brain May Drive Cancer and Birth Defects

University of Virginia School of Medicine scientists have revealed how mistakes in the final step of cell division can have dire consequences for developing brain cells. The findings offer important new insights into cancer and developmental disorders, helping explain how the body tries to protect itself and what happens when it can't.

21 May 2026

Analysis Reveals Blurred Neural Patterns During Failed Cognitive Switches

Most people have experienced the feeling: switching from one task to another, only to find the brain momentarily stuck in the old mode of thinking. Sometimes, even after realizing a strategy no longer works, the mind keeps returning to it anyway.

21 May 2026

Open-Chip Design Separates Fluid Resistance From Wall Confinement to Trace Cell Behavior

Most cancer studies focus on chemical signals or stiff tumor surroundings, but the stickiness of the fluid itself has received little attention. For glioblastoma, the invasion front is about eight times more viscous than the necrotic core, creating a rising resistance that migrating cells must overcome.

21 May 2026

Protein Plays Dual Role by Silencing Thousands of Genes While Keeping Vital Ones Active

The causes of male infertility can be hard to diagnose, with many tests failing to detect genetic defects. Sometimes, infertility doesn't even involve the genes themselves. It can arise from improper folding of the father's DNA in the sperm. If a couple conceives, this mispackaged DNA can damage the lifelong health of the child.

21 May 2026

Engineers Develop New mRNA Adjuvant That Dramatically Amplifies Cancer-Fighting T Cells

Engineers from the University of Houston, MIT and Harvard have developed a new mRNA-based strategy that dramatically amplifies the T-cell response to vaccines - an advance that could lead to far more powerful cancer vaccines and stronger protection against infectious diseases.

20 May 2026

Sensory Nerve Signals Block the Immune System's Response to Lung Cancer

Researchers at the Francis Crick Institute have revealed that sensory nerve signals interfere with the immune system's response to lung cancer. This previously unrecognized neuroimmune connection could be targeted to improve responses to immunotherapy.

20 May 2026

Novel Synthetic Molecules Attack Cell Membranes to Prevent Severe Bacterial Infections

In a new study, researchers show how so‑called TriPcides can target the bacterium Staphylococcus aureus, including antibiotic‑resistant strains such as MRSA. The compounds disrupt the bacteria's ability to cause infection and can also kill dormant bacterial cells, which are often difficult to treat with existing antibiotics.

20 May 2026

Stimulating Early Brain Circuits Partially Restores Vocal Defects Caused by Genetic Mutations

Communication begins long before children learn to speak. Researchers at National Yang Ming Chiao Tung University (NYCU) in Taiwan have now uncovered how early brain activity helps build developing communication circuits via regulating FOXP2/Foxp2, a gene linked to human speech and communication disorders.

20 May 2026

Cell News and Research

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

Dental Pulp Stem Cell Subsets Triggers Rapid Cellular Senescence and Tooth Decay

Scientists Find Key Genetic Boundary That Dictates Immune System Failure

Allison Institute Platform Utilizes Spatial Profiling to Locate Protective Cellular Niches

Researchers Discover That Lesion Cells Fail to Recruit Surrounding Tissue Into Tumor Growth Helpers

How Minimal Medical Care Shifts Amazonian Villagers' Unique Gut Bacteria

Polymer Platforms Help Focus Immune Attack on Cancerous Tumors

Scientists Synthesize Rare Sea Sponge Molecules to Boost Future Cancer Drug Development

Disrupted Honeycomb Cellular Patterns in the Early Brain May Drive Cancer and Birth Defects

Analysis Reveals Blurred Neural Patterns During Failed Cognitive Switches

Open-Chip Design Separates Fluid Resistance From Wall Confinement to Trace Cell Behavior

Protein Plays Dual Role by Silencing Thousands of Genes While Keeping Vital Ones Active

Engineers Develop New mRNA Adjuvant That Dramatically Amplifies Cancer-Fighting T Cells

Sensory Nerve Signals Block the Immune System's Response to Lung Cancer

Novel Synthetic Molecules Attack Cell Membranes to Prevent Severe Bacterial Infections

Stimulating Early Brain Circuits Partially Restores Vocal Defects Caused by Genetic Mutations

Researchers Compare Embryonic and Adult Mouse Brain Targets to Map Memory Networks

Researchers Reverse Immune Cell Dysfunction by Degrading Key Gene Regulatory Proteins

New 3D Cortical Tissue Models Incorporate Microglia to Bridge Preclinical Translation Gaps

Cell Study Challenges Long-Standing View That Individual Human Genomes Evolve Independently

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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