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Speciation process takes place in the presence of maximal gene flow, indicates study

Spatial isolation is known to promote speciation - but researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now shown that, at least in yeast, the opposite is also true. New ecological variants can also evolve within thoroughly mixed populations.

15 Jan 2021

Researchers determine atomic structure of coronavirus protein linked to disease severity

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

DNA-editing technique used to extend lifespan of mice with progeria

Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature aging in children and can significantly shorten their life expectancy.

From National Human Genome Research Institute (NHGRI) 7 Jan 2021

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that a triple drug combination - of irinotecan, cetuximab, and vemurafenib - is a more powerful tumor fighter and keeps people with metastatic colon cancer disease free for a significantly longer period of time compared with patients treated with irinotecan and cetuximab.

24 Dec 2020

Study uncovers how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

From UC San Diego 24 Dec 2020

New version of phototoxic protein helps control intracellular processes

Researchers have designed an improved version of a genetically encoded phototoxic synthesizer that helps regulate intracellular processes through light.

18 Dec 2020

New genomic tool can accurately assess the risk of breast cancer

Breast cancer is the most commonly diagnosed disease in women and is the main cause of cancer-related mortalities in this group of population.

15 Dec 2020

Study sheds new light on a genetic developmental disorder

The rare hereditary developmental disorder, called Meier-Gorlin syndrome, or MGS for short, causes dwarfism, missing patella, a small brain, small ears, and other skeletal abnormalities. This condition leads to stillbirths and miscarriages in severe cases.

15 Dec 2020

Researchers provide a list of genes implicated in congenital heart disease

Over two million babies, children, and adults in the United States are living with congenital heart disease--a range of birth defects affecting the heart's structure or function.

15 Dec 2020

A genetic shortcut to help visualize proteins at work

A group at Gladstone Institutes and UC San Francisco (UCSF) has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of protein complexes.

11 Dec 2020

Appendiceal cancer among young patients harbors a distinct biology, shows study

The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease.

From Vanderbilt University 10 Dec 2020

Researchers identify key molecular processes used by coronaviruses to survive

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.

7 Dec 2020

Research reveals fundamental insights into the causes of severe birth defects

Research by Kai Jiao, M.D., Ph.D., and colleagues at the University of Alabama at Birmingham and in Germany has yielded fundamental insights into the causes of severe birth defects known as CHARGE syndrome cases. These congenital birth defects include severe and life-threatening heart malformations.

3 Dec 2020

A Gene Mutation That Protects Against Disease

Researchers think they have found a fountain of youth, and it is unique to a few French Canadian families.

3 Dec 2020

Scientists unlock new genetic variation in wheat and barley

An international research collaboration, including scientists from the University of Adelaide's Waite Research Institute, has unlocked new genetic variation in wheat and barley - a major boost for the global effort in breeding higher-yielding wheat and barley varieties.

27 Nov 2020

Researchers identify new gene involved in neurodevelopmental disorders

Researchers and physicians constantly search for novel disease genes that can allow them to figure out why medical problems are not diagnosed in patients.

24 Nov 2020

Genetic modification in the ‘coat’ of fatal brain virus may allow it to escape antibodies

A genetic modification in the 'coat' of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers.

23 Nov 2020

Mutation News and Research

Speciation process takes place in the presence of maximal gene flow, indicates study

Researchers determine atomic structure of coronavirus protein linked to disease severity

DNA-editing technique used to extend lifespan of mice with progeria

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

Study uncovers how shattered chromosomes make cancer cells more aggressive

New version of phototoxic protein helps control intracellular processes

New genomic tool can accurately assess the risk of breast cancer

Study sheds new light on a genetic developmental disorder

Researchers provide a list of genes implicated in congenital heart disease

A genetic shortcut to help visualize proteins at work

Appendiceal cancer among young patients harbors a distinct biology, shows study

Researchers identify key molecular processes used by coronaviruses to survive

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Research reveals fundamental insights into the causes of severe birth defects

A Gene Mutation That Protects Against Disease

Scientists unlock new genetic variation in wheat and barley

Researchers identify new gene involved in neurodevelopmental disorders

Genetic modification in the ‘coat’ of fatal brain virus may allow it to escape antibodies

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