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Autophagy: A Double-Edged Sword in Cancer and Protein Conformational Disorders

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its potential as a therapeutic target and the challenges of tipping the balance between protection and harm.

20 May 2025

How LEM-3 Cleaves DNA Bridges During Cell Division Revealed

If DNA bridges remain between chromosomes after cell division, chromosomes become improperly segregated, resulting in genetic instability and cancer.

20 May 2025

Liver Energy Storage Tied to Genetic Activity in PPP1R3B

A new study published in Science Advances reveals that a single gene plays a big role in how the liver stores energy, a process that's critical for overall health and for managing diseases like type 2 diabetes.

19 May 2025

Novel Bacterial Immune Weapon that Starves Viral Invaders

The discovery of Cat1 reveals how CARF effectors use complex structures to inhibit viral replication, advancing our understanding of bacterial immune responses.

19 May 2025

Molecular Mechanism Revealed by Stop-Motion Electron Microscopy

Using electron microscopy, researchers illustrate FusB's role in antibiotic resistance, providing a molecular-level understanding of fusidic acid interactions.

19 May 2025

Single Cell Sequencing Uncovers Hidden Drivers of Severe Celiac Disease

Scientists have identified mutated immune cell clones that could point to improved treatment for refractory celiac disease.

17 May 2025

Carriers of Recessive Disorders Face Hidden Health and Reproductive Problems

As a group, carriers of recessive disorders are slightly less healthy and have a reduced chance of having offspring.

16 May 2025

Breakthrough Study Identifies Unique Breast Cancer Genes in South African Women

Genetic factors contribute to some 30% of breast cancer cases in SA, necessitating investment in genomic research in African contexts.

16 May 2025

New 3D Stem Cell Model Mimics Human Amniotic Sac Development

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilization.

16 May 2025

Scientists Develop EvoCAST for Efficient and Accurate Gene Insertion

Ask scientists what gene editing tool is most needed to advance gene therapy, and they'd probably describe a system that's now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.

16 May 2025

Real Time RNA Tracking in Plants Using Fluorescent Biosensors

RNA acts as a messenger inside cells, carrying instructions from DNA that are translated into proteins that are essential for how cells function.

15 May 2025

Variance Analysis Enhances Genetic Risk Prediction for Blood Cell Traits

A Nature Communications study shows that incorporating variance polygenic scores (vPGS) and variance QTLs (vQTLs) improves genetic risk prediction for blood-related diseases, offering new insight into phenotype variability and lifestyle factors like alcohol intake.

15 May 2025

Viral circRNAs Sponge Up Host miRNAs to Weaken Immune Response

In a significant breakthrough, researchers from Florida Atlantic University’s Charles E. Schmidt College of Medicine have uncovered a previously unknown mechanism that allows the human immunodeficiency type 1 virus (HIV-1) to evade the body’s natural defenses, thereby facilitating its survival and replication.

14 May 2025