Pharmacology News and Research

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Pharmacology is the study of how chemical substances interact with living systems. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, interactions, toxicology, therapy, and medical applications and antipathogenic capabilities.

The Future of Nanobiotechnology: Ethical Considerations

Prosthetics moved by thoughts. Targeted treatments for aggressive brain cancer. Soldiers with enhanced vision or bionic ears.

13 Jul 2023

AMP Releases CYP3A4 and CYP3A5 Genotyping Assay Recommendations

The Association for Molecular Pathology (AMP), the world’s leading professional society for molecular diagnostics, released consensus recommendations today to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, encourage standardization of testing across labs, and better patient care.

11 Jul 2023

Elaborate 3D Structures of DNA That Mimics Protein Functions

According to a study from scientists at Weill Cornell Medicine and the National Heart, Lung, and Blood Institute, a division of the National Institutes of Health, DNA can imitate protein activities by folding into complex, three-dimensional structures.

22 Jun 2023

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment.

12 Jun 2023

Combining Proteins With Nano-Based Engineering to Create Circuits

Penn State researchers have developed the first protein-based nano-computing agent that can be used as a circuit.

29 May 2023

How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

29 May 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Study Provides a New Picture of How Bacterial Cells Repair Faulty DNA

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

17 May 2023

Discovery of Shanghai APP Mutation Offers New Avenues for Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of millions of people worldwide, and it is the most common cause of dementia.

15 May 2023

Manipulating Brain Cells via Light Irradiation

An international research team, comprising scientists from DZNE, University Hospital Bonn, the Netherlands, and the US has been awarded a US$ 1.3 million grant by the "Human Frontier Science Program" to investigate brain immune cells and manipulate them via light irradiation.

8 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.

2 May 2023

New Approach Could Power the Development of Advanced Cell Therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

2 May 2023

How Bacteria Take Action to Break Out of Dormancy

Solving a riddle that has confounded biologists since bacterial spores -; inert, sleeping bacteria -; were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life.

2 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Csx28 Membrane Protein Enhances CRISPR's Anti-Viral Defense

CRISPR achieved scientific popularity for its capacity to quickly and precisely edit genes. At the core, however, CRISPR systems are immune systems that aid bacteria to safeguard themselves from viruses through targeting and abolishing viral RNA and DNA.

28 Apr 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

Novel Protein Involved in Tumor Suppression Identified

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

7 Apr 2023

Curcumin could enhance ovarian cancer treatments

A pharmacology researcher at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) has co-authored a new study that makes a strong case for why a golden spice commonly found in curry could enhance ovarian cancer treatments.

23 Mar 2023

Macrophages likely to be a potential target for ER+ breast cancer

Most immunotherapies that aim to increase T cell activity are ineffective in treating estrogen receptor-positive (ER+) breast cancer. A new study of invasive ER+ breast cancers led by researchers at the University of Pittsburgh School of Medicine implies that targeting a different type of immune cell called macrophages may be a more effective approach.

From University of Pittsburgh 20 Mar 2023