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New technology efficiently detects gene mutation in blood with low error rate

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.

5 May 2021

Study reveals genetic mutation associated with exfoliation syndrome

A team of researchers from the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS) and Bioprocessing Technology Institute (BTI), as well as Singapore Eye Research Institute (SERI), have identified a genetic mutation (functionally defective CYP39A1 gene) associated with exfoliation syndrome, the most common cause of glaucoma.

5 May 2021

Mutant corn gene found to increase the amount of sugars in the seeds and leaves

An abnormal accumulation of carbohydrates—starches and sugars—in the kernels and leaves of a mutant line of corn can be traced back to a single misregulated gene, and this finding provides insights into how the plant responds to stress.

From Penn State University 5 May 2021

Study reveals relationship between form and function in the genetic material of dinoflagellates

A new study unfolds a longstanding puzzle about the connection between the function and form in the genetic material of a complex group of algae.

5 May 2021

Study finds how SARS-CoV-2 hijacks human cell machinery to disrupt the immune response

SARS-CoV-2 hijacks human cell machinery to disrupt the immune response, enabling it to cause infection, replicate, and cause disease.

4 May 2021

New genetic database maps how immune disorders evolve

A first-of-its-kind genetic database for autoinflammatory and autoimmune disorders has been created by Japanese researchers.

4 May 2021

Researchers devise a small-molecule cocktail to protect stem cells from stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Researchers study the unique genomic organization of coral symbionts

According to recent findings, the genome of single-celled plankton, called dinoflagellates, is arranged in an extremely unusual and strange manner. The study results set the foundations for further research into these vital aquatic species and significantly broaden the understanding of what a eukaryotic genome can look like.

3 May 2021

New therapeutic target for patients with acute myeloid leukemia

According to a new study, targeting a pathway that is critical for the survival of some cases of acute myeloid leukemia could open up a new therapeutic route for patients.

3 May 2021

New gene therapy could help treat Duchenne muscular dystrophy

Researchers from UT Southwestern used a new kind of gene therapy to successfully treat mice with Duchenne muscular dystrophy (DMD), distinctively employing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein missing in several DMD patients.

3 May 2021

New gene editing tool helps analyze the mysterious quirk of bacteria

While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations.

3 May 2021

Shortage of DNA building blocks triggers inflammation

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell.

3 May 2021

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.

30 Apr 2021

Geisinger receives $3.6 million from NCI to study the role of genetic variation in cancer

The National Cancer Institute, part of the National Institutes of Health, has awarded a 5-year, $3.6 million contract to Geisinger to study the role of genetic variation in cancer.

30 Apr 2021

Researchers discover new approach to reform plant breeding and genetics

The research was conducted at the Department of Food Science at the University of Copenhagen (UCPH FOOD) with professor emeritus Lars Munck as coordinator and builds on earlier work since 1963 at Svaloef Plant Breeding Institute and the Carlsberg Laboratory.

28 Apr 2021