Chromatin News and Research

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Experts identify proteins that regulate dual processes

According to recent research, the protein UBR7 acts as a histone chaperone and controls histone re-deposition at certain sites at the time of DNA replication.

22 Dec 2021

Experts identify first non-coding RNA that controls chromosome loop formation

Recent research carried out by scientists from Massachusetts General Hospital (MGH) reveals that a significant player in the healthy development of female embryos also performs a vital role in controlling the behavior of chromosome loops and gene expression in both sexes.

7 Dec 2021

Live-cell probes enable visualization of the elongation phase of transcription

A genetically encoded “live-cell” probe developed by scientists from Tokyo Tech pinpointed phosphorylated Ser2 in the enzyme RNA polymerase II.

7 Dec 2021

Researchers identify a new approach to triggering differentiation in acute myeloid leukemia

In the late 1980s, scientists developed a revolutionary approach to treating acute myeloid leukemia (AML), a type of blood cancer. Called differentiation therapy, it amounted to a bona fide cure for many patients.

2 Dec 2021

Researchers use X-ray from 3rd synchrotron facility to analyze 3D structure of chromosomes

Threads or earphone cables placed in tight spaces get easily tangled. On the contrary, our body's long and loose DNA packs into rod-shaped chromosomes one-millionth its size when the cell divides.

30 Nov 2021

Study shows how a common gene mutation robs people of natural cancer protection

Scientists from the University of Virginia School of Medicine have identified how a common gene mutation deprives people of natural protection against cancer.

15 Nov 2021

Formation of transcription factories in living cells resembles the condensation of liquids

It is essential for cells to control precisely which of the many genes of their genetic material they use. This is done in so-called transcription factories, molecular clusters in the nucleus.

5 Nov 2021

Researchers reveal the dual function of a zinc finger protein

Human genome mapping was followed by rapid scientific advancements that showed the astonishingly complex world of genetics.

29 Oct 2021

Study sheds light on the regulation of epigenetic modifications during the development

The hereditary material, DNA, interacts with proteins present in the cell nuclei and forms a tightly packed complex with proteins called “chromatin”.

29 Oct 2021

Research reveals new mechanism by which plants can rapidly activate defenses against infections

New work led by Carnegie's Kangmei Zhao and Sue Rhee reveals a new mechanism by which plants are able to rapidly activate defenses against bacterial infections.

27 Oct 2021

Experts come up with a powerful tool for illustrating genome folding

The intricate folds and arrangements of protein and DNA bundles inside the microscopic boundaries of a single human cell instruct the fate of an individual

13 Oct 2021

Genome Research' special issue covers advanced developments in single-cell genomics

Genome Research (https://genome.org) publishes a special issue highlighting novel advances and insights in Single-cell Genomics.

5 Oct 2021

Remnants of organic molecules and chromatin found in nuclei of ancient dinosaur cells

A team of scientists from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences and from the Shandong Tianyu Museum of Nature (STM) has isolated exquisitely preserved cartilage cells in a 125-million-year-old dinosaur from Northeast China that contain nuclei with remnants of organic molecules and chromatin.

27 Sep 2021

How does the KLF4 transcription factor influence gene expression?

Scientists have led a research group to identify a mechanism using which transcription factor KLF4 can influence gene expression.

24 Sep 2021

Premature aging of the tracheobronchial stem cells could contribute to chronic lung disease

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.

22 Sep 2021

Researchers seek to point a way toward a unified theory for DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

Study uncovers mechanism where two transcription factors stabilize each other’s binding to DNA

Researchers have discovered an exclusive mechanism through which two transcription factors stabilize each other’s binding to DNA in fission yeast.

14 Sep 2021

Study unearths previously unknown role of CTCF, the transcription regulator

Researchers discovered evidence that CTCF governs chromatin accessibility, the mechanism of opening tightly spooled DNA facilitating gene expression.

9 Sep 2021

Study reveals mechanisms promoting overall glioma tumor growth

Researchers from Northwestern Medicine unearthed the epigenetic processes involved in the regulation of multiple oncogenes in glioma cells.

31 Aug 2021

New technique can map out nearly all of the regulatory switches across a maize genome

Getting a full understanding of how genes are regulated is a major goal of scientists worldwide. Now, a Florida State University professor and his research partners have developed a technique that can map out nearly all of the likely regulatory switches across a genome.

16 Aug 2021