Preclinical News and Research

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Research may Offer a New Way to Break Through Cancer's Hypoxia-Induced Defenses

For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. Cancer cells, on the other hand, can thrive in these hypoxic conditions, which render tumors less susceptible to anti-cancer treatments, including radiation.

11 Jul 2023

New Oral Probiotic Delivery System Keeps “Good” Bacteria Safe

Probiotics can help maintain a healthy gut microbiome or rebuild populations of “good bacteria” following an antibiotic course. They may now be utilized as a viable treatment strategy for certain intestinal diseases like Crohn’s disease.

22 Jun 2023

Rescue Treatment Found From Plant Extracts for People With Ataxia

A University of California, Irvine-led team of researchers have discovered that extracts from plants used by the Kwakwaka'wakw First Nations peoples in their traditional botanical medicine practices are able to rescue the function of ion channel proteins carrying mutations that cause human Episodic Ataxia.

22 Jun 2023

Photoacoustic Spectral Analysis Shows Promise for Noninvasive Diagnosis of Tumors

Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the "tumor microenvironment" (TME).

14 Jun 2023

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment.

12 Jun 2023

Researchers Discover Novel Combination Therapy to Counter Antibiotic-resistant Mycobacterium Abscessus Infections

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Nanyang Technological University Singapore (NTU Singapore) and National University Hospital (NUH), have discovered a novel therapy by combining two antibiotics, rifaximin and clarithromycin, to treat Mycobacterium abscessus (M. abscessus), a non-tuberculous mycobacterium (NTM) that causes chronic lung-related infections.

9 Jun 2023

Scientists Integrate Multiple Therapeutic Approaches to More Effectively Target Brain Metastatic Melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

1 Jun 2023

Game-Changing Research Shows Astrocytes as Key Regulators of Alzheimer's Disease Progression

Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates-;a telltale sign of Alzheimer's brain pathology-;never go on to develop Alzheimer's-associated dementias?

30 May 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Chemical Modification Improves Non-Viral Gene Editing as Well as a New Type of DNA Repair

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

12 May 2023

Vector Biolabs Expands Viral Vector Manufacturing Capacity and Adds to QC Capabilities

Vector Biolabs, a custom design and manufacturing service provider for AAV and adenovirus viral vectors announced the completion of a facility expansion to meet growing demand.

12 May 2023

Launching Revvity: A Scientific Solutions Company Powering Innovation from Discovery to Cure

Transformation aimed at revolutionizing next generation scientific breakthroughs that solve the world’s greatest health challenges

From Revvity 9 May 2023

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

New Bio-Inspired Molecules can Enhance Bone Regeneration in Mice

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

2 May 2023

Study Uncovers a Protein-Protein Interaction Related to Parkinson's Disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

24 Apr 2023

Abnormal Immune Activity in Astrocytes Causes Dementia-Related Cognitive Deficits

People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss, according to a preclinical study by a team of Weill Cornell Medicine investigators.

21 Apr 2023

Deletion of Specific Protein Creates a Hostile Environment for Aggressive Breast Tumors

Scientists at VCU Massey Cancer Center discovered that the deletion of a specific protein creates a hostile environment for tumor cells and significantly subdues breast cancer growth and spread.

13 Apr 2023

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates -; bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

11 Apr 2023

Designing a Lipid Nanoparticle to Safely Deliver mRNA to the Pancreas

Therapeutics that use mRNA-;like some of the COVID-19 vaccines-;have enormous potential for the prevention and treatment of many diseases.

4 Apr 2023

Study helps understand at the cellular level how physical activity contributes to fitness during aging

Regular exercise can guarantee quality of life and longevity, specialists agree. However, exactly how exercise influences the functioning of muscle cells is poorly understood.

30 Mar 2023