Antigen News and Research

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Tolerogenic Dendritic Cells in Gut Prevent Allergic Reactions to Food

The immune system must be able to rapidly target invaders such as viruses while avoiding innocuous stimuli, or allergies may develop.

15 Apr 2025

Novel Microscopy Reveals Two-Stage T-Cell Activation During Viral Infection

The research teams led by Wolfgang Kastenmüller and Georg Gasteiger utilized advanced microscopy techniques to investigate the activation and proliferation of specific immune cells, known as T-cells, during viral infections.

11 Apr 2025

USC Engineers Develop EchoBack CAR T-Cells for Cancer Treatment

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

3 Apr 2025

How Does DNA Unwind? Study Explores Helicase Mechanisms In DNA Replication

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

28 Mar 2025

How B Cells Know When to Mutate—and When to Chill

Study reveals B cells suppress mutations during rapid division, enhancing immune response and offering critical insights for vaccine and treatment development.

27 Mar 2025

New Insights into How B Cells Strategically Clone High-Affinity Antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

20 Mar 2025

Visualizing the Fundamental Process of DNA Strand Separation

The exact moment DNA starts to unravel has been seen by scientists for the first time, exposing a chemical process that is essential for DNA to be the molecule that codes for all life.

20 Mar 2025

$30 Million Grant Supports AI-Powered Antibody Therapy Development

An ambitious project led by Vanderbilt University Medical Center investigators aims to use artificial intelligence technologies to generate antibody therapies against any antigen target of interest.

10 Mar 2025

Unlocking the Secrets of Fertilization Inhibition

A research team headed by Yale scientists has elucidated the workings of a natural biological process that blocks the interaction between sperm and egg, thus inhibiting fertilization.

4 Mar 2025

Regulating T Cell Volume and Proliferation via Water Influx

Researchers at the Francis Crick Institute have demonstrated that the influx of water is a requirement for the activation and proliferation of immune cells, such as T cells when they encounter a threat.

27 Feb 2025

RNA Splicing Errors May Hold the Key to Beating Gliomas Using Immunotherapy

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

26 Feb 2025

T Cells May Hold the Secret to Fighting Dengue Virus

Children who experience multiple cases of dengue virus develop an army of dengue-fighting T cells, according to a new study led by scientists at La Jolla Institute for Immunology (LJI).

25 Feb 2025

Immunotherapy Breakthrough Targets Jumbled Proteins in Glioma

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.

20 Feb 2025

CRISPR Unlocks ‘Sleeping’ Genes—A Potential Cure for Prader-Willi Syndrome?

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for targeted therapies in genetic disorders.

20 Feb 2025

Researchers Uncover CAR Molecule Transfer Mechanism

Engineered immune cells known as CAR-T cells are utilized in cancer treatment. Researchers at Uppsala University have recently identified that CAR molecules can be transferred from CAR-T cells to other T cells within the tumor microenvironment.

4 Feb 2025

Leveraging AI to Aid the Development of T Cell Vaccine Candidates

An exciting collaboration between the Ragon Institute and the Jameel Clinic at MIT has achieved a significant milestone in leveraging artificial intelligence (AI) to aid the development of T cell vaccine candidates.

29 Jan 2025

New Method Helps T Cells Live Longer and Fight Cancer More Effectively

Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media.

29 Jan 2025

New computational strategy enables design of drug-induced protein interactions

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell therapies and synthetic biology.

22 Jan 2025

AI-Powered Platform for Designing Novel Protein Interactions

Researchers at EPFL have opened up a world of possibilities in the computational design of molecular interactions for biomedicine by using deep learning to create new proteins that bind to complexes involving other small molecules, such as hormones or medications.

17 Jan 2025