Colorectal Cancer News and Research

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Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

Researchers Reveal Overlooked Colorectal Cancer DNA Repair Breakdown Fingerprint

Researchers from University of California San Diego and collaborators have identified a previously overlooked pattern of DNA mutations in colorectal cancer.

20 Aug 2026

New Research Links Chronic Inflammation to Tumor Microenvironment Epigenetic Changes

Immune checkpoint inhibitors have revolutionized cancer treatment, yet many colorectal tumors remain resistant. Even among patients who initially respond, more than half eventually develop resistance, highlighting the need to better understand how tumors evade immune attack.

19 Aug 2026

New Oral Nanomedicine Leverages Gut Metabolites to Destroy Tumors

A joint research team-led by Professor Young Seok Cho from the School of Medicine, alongside Professor James J. Moon from the University of Michigan-has successfully developed the world's first oral, microbiome-based nanomedicine.

12 Aug 2026

Mapping Alternative RNA Splice Isoforms to Identify Novel Therapeutic Targets

Proteogenomics represents a transformative approach in cancer research that bridges the gap between genomic alterations and their functional consequences at the protein level.

8 Aug 2026

Tireless Stem Cells Drive Continuous Renewal Across High Friction Human Intestines

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells. These stem cells can both replace the various types of intestinal cells that have been lost as well as renew themselves.

6 Aug 2026

Kobe University Unveils Mass-Producible Off-the-Shelf Cancer Fighters

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

24 Jul 2026

Gut Microbiome Signatures Correlate With Clinical Efficacy in Immunotherapy Outcomes

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

9 Jul 2026

Advanced Bioinformatics Models Reveal Bacterial Function in Colon Cancer Patients

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

29 Jun 2026

Global Study Identifies Robust Gut Microbiome Signature in Colorectal Cancer

Researchers have long suspected that the gut microbiome – the community of bacteria and other microorganisms living in the intestine – is closely linked to colorectal cancer.

25 Jun 2026

Common Genetic Variant Increases Colorectal Cancer Risks for General Population

A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University, and institutions across the U.S., have published a landmark paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the TGFBR1 gene found in approximately 14 percent of the general population.

24 Jun 2026

New Genetic Discovery Explains Why Colorectal Cancer Spreads so Quickly

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology researchers.

23 Jun 2026

Targeting Iron Metabolism Offers a New Strategy to Kill Cancer Cells

Researchers from the University of Michigan Health Rogel Cancer Center have discovered a key metabolic pathway that allows colorectal cancer cells to accumulate large quantities of iron. Blocking that pathway reduced iron levels and caused the cancer cells to die.

22 Jun 2026

New Molecular Eraser Targets mRNA of Deadly Cancer Protein

Many of the deadliest forms of cancer are caused by a pathological mutation in the RAS protein. Yet, to date, no effective treatment for this cancer protein has been found. A new research approach aims to prevent the protein from forming in the first place by destroying its blueprint – the mRNA.

11 Jun 2026

New Cell Therapy Modifies Natural Killer Cells Against Cancer

Scientists have made great progress in harnessing the body's own immune cells to treat so-called liquid tumors, cancers of the blood and lymphatic system.

11 Jun 2026

Scientists Identify EHMT2 Enzyme as Main Cause of 5-FU Failure

One of the most widely used chemotherapeutic agents for colorectal cancer is 5-fluorouracil (5-FU), a cornerstone treatment that has improved outcomes for countless patients.

9 Jun 2026

Genomewide CRISPR Screen Reveals Unexpected Structural Protein Link Behind Chronic Colon Inflammation

Since a landmark 2009 study, researchers have known that a common gut bacterium, Bacteroides fragilis, drives colon tumor formation, potentially leading to colorectal cancer, by secreting a toxin that damages the lining of the colon. But until now, the exact mechanism the toxin uses to latch onto those cells remained a mystery.

25 May 2026

New Analysis Uncovers Evolutionary Adaptations Within Human Gut Bacteria

The human gut harbors a complex ecosystem of trillions of microorganisms (the microbiome), which influences digestion, the immune system and metabolism.

8 May 2026

Study Highlights Unexpected Role of Stard7 in Colorectal Cancer Development

A new study led by researchers at the University of Liège highlights the unexpected role of Stard7 in the development of intestinal cancers.

3 Apr 2026

Bacteria-Powered Drug Discovery: A Greener Path to Curing "Undruggable" Cancers

Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilize, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.

4 Mar 2026

A Molecular Tug-of-War Shapes Gene Regulation and Disease

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders - including cancers, neurodegenerative diseases and immune disorders - originate, as well as how to potentially treat them, according to researchers at Penn State.

18 Dec 2025