DNA Damage News and Research

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Antibody-Based Strategy Makes Stem Cell Transplants Safer

Stem cell transplantation (also called bone marrow transplantation) and gene therapy are among the most powerful curative approaches for blood diseases such as sickle cell disease, b-thalassemia, immune deficiencies, and some blood cancers.

9 Jul 2026

New Review Outlines Diverse Biological Triggers of Cellular Senescence

A new review was published in Volume 18 of Aging on June 22, 2026, titled "The multifaceted inducers of cellular senescence."

8 Jul 2026

Advanced Bioinformatics Models Reveal Bacterial Function in Colon Cancer Patients

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

29 Jun 2026

Real-Time Molecular Tool Observes Complex Immune System Changes

A lot of things need to go right on a molecular level for immune cells to launch an adaptive response to an infection.

24 Jun 2026

Migrating Neurons Break and Repair Their Own DNA During Brain Cortex Formation

Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the areas where they form neural circuits in the brain cortex.

18 Jun 2026

Salk Researchers Uncover Specialized Plant Protein for DNA Repair

Similar to the way DNA damage can contribute to human diseases like cancer, it can also disrupt growth, development, and survival in plants.

9 Jun 2026

Cornell Researchers Develop Safer CRISPR Technique Using DNA Nicks

Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues by refining a recently developed CRISPR-based genetic technique in fruit flies, enabling researchers to better study how genes contribute to development and disease.

28 May 2026

High Protein Levels Bypass Functional BRCA Defenses to Generate Toxic Double-Strand Genomic Breaks

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells.

22 May 2026

Sensory Nerve Signals Block the Immune System's Response to Lung Cancer

Researchers at the Francis Crick Institute have revealed that sensory nerve signals interfere with the immune system's response to lung cancer. This previously unrecognized neuroimmune connection could be targeted to improve responses to immunotherapy.

20 May 2026

Cell Study Challenges Long-Standing View That Individual Human Genomes Evolve Independently

Scientists at Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered that large pieces of DNA can transfer directly between human cells, and the DNA can persist and change how the recipient cell functions.

20 May 2026

Dual-Action Protein Found to Fuel and Repair Cancer

According to a recent study, a protein best known for fueling cancer development also aids in the survival of damaged tumor cells by repairing their DNA, which might impact how certain cancers are treated.

18 May 2026

Selective Elimination of Harmful Senescent Cells Supports Healthy Aging

A new review was published in Volume 18 of Aging-US on May 4, 2026, titled "Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions."

15 May 2026

Scientists Discover How DNA Damage Modulates the Tumor Microenvironment for Therapy

Researchers have identified a pathway that triggers an immune response in cells with defective DNA repair.

14 May 2026

Inherited Genetic Pathways Shape Individual Cancer Risk and Outcomes

Why do two people with the same cancer diagnosis-the same stage, the same cell type, and the same clinical profile-often have completely different outcomes? For decades, scientists have studied acquired mutations in cancer to find answers, but mutations alone explain only part of the story.

12 May 2026

DNA Study Reveals the Personal Pathways Behind Different Tumors

Why do two individuals with the identical cancer diagnosis—the same cell type, the same stage, and the same clinical profile—often experience very different outcomes? Scientists have been researching acquired mutations in cancer for decades in an effort to uncover solutions, but mutations by themselves only account for a part of the problem.

11 May 2026

New CRISPR System Destroys Diseased Cells With High Precision

A new kind of CRISPR that destroys cells rather than gene editing them has shown potential for killing sick cells while leaving healthy cells untouched.

8 May 2026

Metabolic Pathway Loss Makes Cancer Cells Vulnerable to PARP Drugs

Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their vulnerability to a class of anticancer drugs known as PARP inhibitors, a study led by UT Southwestern Medical Center researchers shows.

5 May 2026

MD Anderson Researchers Map DNA Replication Stress at Single-Cell Resolution

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with single-cell resolution.

28 Apr 2026

New Study Uncovers Previously Undetected Form of DNA Damage

In everyday life, our genetic material is constantly under attack from many factors. Environmental influences such as light, along with internal processes like inflammation, can generate oxidative stress that damages DNA and its downstream partner, RNA, which can lead to faster aging and diseases such as cancer.

24 Apr 2026

How Mitochondrial Damage Accelerates Stem Cell Aging

Hematopoietic stem cells (HSCs), the cells that produce all blood cell types, start to lose their efficacy as one ages, which eventually reduces the ability to maintain healthy blood and a robust immune system.

17 Apr 2026