DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Unusual DNA Structure i-DNA Linked to Cancer Regulation

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes.

3 Feb 2026

New Research Reveals RFC's Dynamic Partnership in DNA Synthesis

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its code and build new strands.

2 Feb 2026

How DNA Leakage into the Cytoplasm Drives Ruijs-Aalfs Syndrome

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal metabolic activity and external stressors such as radiation and chemical agents.

2 Feb 2026

Defective DNA Protein Repair Triggers Inflammation and Premature Aging

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice.

31 Jan 2026

Natural Molecular Brake Prevents Uncontrolled DNA Replication in Cells

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a cell divides – which they need to do constantly. Without this process, we would die.

29 Jan 2026

Giant Ushikuvirus Discovery Sheds Light on the Origins of Life

The origin of life on Earth becomes even more fascinating and complex as we peer into the mysterious world of viruses.

8 Jan 2026

Mapping the Four Dimensional Organization of the Human Genome

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

23 Dec 2025

Study Uncovers Principles Guiding Replication Initiation Across the Human Genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, and genetic disorders.

4 Dec 2025

Gene Transcription Start Sites Identified as Hidden Mutational Hotspots

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.

27 Nov 2025

DNA Rigidity Inside the Nucleosome Regulates INO80 Positioning

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the physical structure and shape of DNA, not just genetic information, are key components of DNA transcription.

26 Nov 2025

Bacteriophages Facilitate the Survival of Lactic Acid Bacteria in Kimchi Fermentation

The World Institute of Kimchi (President: Hae Choon Chang), a government-funded research institute under the Ministry of Science and ICT, has confirmed in a new study that bacteriophages, which were previously considered a 'nuisance' during the process of food fermentation, actually play the role of key helpers that facilitate the survival of lactic acid bacteria (LAB).

21 Nov 2025

Protein Dysfunction Could be the Cause of Diseases Resulting From Shortened Telomeres

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Breakthrough Cryo-EM Study Maps Herpes Replication Protein in New Detail

An international research team has successfully identified the initial high-resolution structures of the herpes simplex virus origin-binding protein (OBP), which is an essential element in viral DNA replication that has remained structurally uncharacterized for the past forty years.

24 Oct 2025