Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

New Research Reveals Yeast-Based Production of Human DNase1 Protein

Research on yeast-based production of human DNase1 offers a cost-effective alternative to mammalian cells, enhancing treatment options for cystic fibrosis.

29 May 2025

Unraveling the Mysteries of the Barr Body and Aging

Aging in female mice shows increased gene activity on the second X chromosome, offering insights into cardiovascular disease and neurodegenerative disorders.

28 May 2025

Scientists Develop EvoCAST for Efficient and Accurate Gene Insertion

Ask scientists what gene editing tool is most needed to advance gene therapy, and they'd probably describe a system that's now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.

16 May 2025

Depleting TM6SF2 in the Gut Worsens Liver Fat Buildup, Study Finds

A new study finds that gut-specific TM6SF2 depletion exacerbates liver fat accumulation and dysbiosis in mice on high-fat diets, highlighting its importance in gut-liver metabolic regulation.

12 May 2025

Novel Therapeutic Strategy for Healthy Aging and Longevity

An international study led by the Institut de Neurociències at the UAB (INc-UAB) found that raising levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health as they age.

8 May 2025

Likarda Paper Highlights Hydrogel Encapsulation with CSS Can Overcome Major Obstacle of Liver Cell Therapies

Likarda, a leading biotech company specializing in the development of enabling technologies for the delivery of both cell therapies and large molecule biologics, announced a new peer-reviewed publication that demonstrates a promising improvement in the effort to develop liver cell-based therapies for patients with chronic liver disease.

23 Apr 2025

Researchers Develop STITCHR to Insert Whole Genes Without Unwanted Mutations

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

12 Apr 2025

Study Explores the Physiological Role of Nwd1 Gene in MASH Pathogenesis

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated with significant global public health concerns.

12 Mar 2025

Cellular Changes as Lung Damage Worsens During COVID-19 Revealed

Changes in the cellular response during lung damage caused by SARS-CoV-2 – the virus behind COVID-19 – have been uncovered.

10 Mar 2025

Unlocking the Role of lncRNAs in MASLD and Liver Fibrosis

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), represents a widespread health concern, impacting approximately 30% of the global adult population.

3 Mar 2025

Harbour BioMed and Insilico Collaborate on Advanced AI-Driven Antibody Discovery

Harbour BioMed (HKEX: 02142, the "Company"), a global biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics focusing on immunology and oncology, and Insilico Medicine ("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, today announced a strategic collaboration to accelerate the discovery and development of innovative therapeutic antibodies, leveraging their respective technological strengths in antibody discovery and artificial intelligence.

22 Feb 2025

New 3D Lung Model Offers Personalized Aerosol Therapeutic Insights

Respiratory diseases are a challenging problem to treat. Inhalable medicines are a promising solution that depend on the ability to deliver tiny particles known as aerosols to the correct location in the lungs at the correct dosage.

21 Feb 2025

New Computational Approach Speeds Up Genetic Variant Analysis for Disease Risk

Argonne computer scientists enabled a new research modality in the search for causality among genetic variants for a given disease.

18 Feb 2025

New Method for Treating Muscle Atrophy Using Regenerative Medicine

Researchers from Tokyo Metropolitan University have developed a way to treat ageing-related muscular atrophy using regenerative medicine.

18 Feb 2025

Infant Cystic Fibrosis Linked to Stunted Microbiome Development

Findings from a new Dartmouth-led study, published in the journal mBio, highlight key differences in the gut microbiome (communities of bacteria) of infants with cystic fibrosis (CF) compared to that of healthy infants, and how these alterations may adversely affect their health.

14 Feb 2025

Cryo-EM Uncovers Hidden Complexity in Collagen Structure

The most prevalent protein in the body, collagen, has long been thought to be a predictable structural element of tissues.

10 Feb 2025

Research Identifies Key Immune Cells for Liver Repair

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific activation state of one of these cell types is required for tissue repair following injury.

27 Jan 2025

Bacterial Growth in Mucus Leads to Formation of Cable-Like Structures

Scientists at Caltech and Princeton University have discovered that bacterial cells growing in a solution of polymers, such as mucus, form long cables that buckle and twist on each other, building a kind of "living Jell-O."

20 Jan 2025

New Approach Aims to Make CRISPR Therapy Safer and More Effective

CRISPR is a powerful gene-editing tool that holds enormous potential for treating genetic diseases by allowing scientists to cut, replace, or delete mutations in DNA.

16 Jan 2025

Intricate Relationship Between Goblet Cells and the Gut Microbiome

In a new study, scientists from the University of California, San Diego have shed light on the crucial function goblet cells—specialized gut-lining cells—play in preserving a balanced and healthy immune environment in the gastrointestinal (GI) tract. Dr. Fernanda Raya Tonetti led the project, and Dr. Cristina Llorente made important contributions.

13 Nov 2024