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Researchers Develop 3D Organoids that Reflect the Complexity of Brain Tumors

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

16 Apr 2026

New Technology Tracks Real-Time Gene Activity to Find Common Disease Targets

Diseases like cancer or neurodegeneration are known to arise from genetic misfires. But treating such complex conditions hasn't been simply a matter of identifying the malfunctioning genes involved. With hundreds of genetic mutations spanning diverse pathways at play, connecting the dots between a constellation of mutations and a specific outcome has proved to be enormously difficult.

16 Apr 2026

Researchers Map the Genetic History of Savanna and Forest Elephant Species

In the largest genomic mapping of Africa's elephants, an international team of researchers shows that elephant history is defined by the ability to move across large distances and exchange genes throughout the African continent. But as the elephants' living space is becoming increasingly patchy, the study documents the visible genetic consequences of isolation – and points to approaches that help to incorporate genomics into current and future elephant conservation.

16 Apr 2026

1,116 Genomes Mapped to Reveal Hidden Human DNA Variation

The 1KCP pangenome enhances genetic research by mapping diverse DNA variations, crucial for understanding disease risk and advancing population genetics.

16 Apr 2026

Genetic Barcodes Reveal Early Origins of Human Peripheral Nerves

Millions of neurons branch throughout our bodies, keeping them in close communication with our brains. This peripheral network begins to take shape long before birth, as the cells of a growing embryo move into position and adopt their specialized roles.

15 Apr 2026

New Genetic Approach Protects Tomato Yield From Highly Virulent Viruses

Tomato yellow leaf curl disease (TYLCD), caused by begomoviruses, is a global problem in tomato production, affecting yield.

15 Apr 2026

Largest Genetic Study Reveals New Biological Clues for Severe Pregnancy Sickness

The USC research team that recently identified the hormone-encoding gene GDF15 as a key driver of pregnancy sickness has identified 9 additional genes linked to its most severe form, hyperemesis gravidarum (HG).

15 Apr 2026

Brain Discovery Links Interhemispheric Communication to Spatial Memory

A team led by the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has identified a brain circuit essential for spatial memory.

15 Apr 2026

Scientists Discover New Rare Genetic Disease Using Whole Exome Sequencing

Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators used a genetic sequencing technique called whole exome sequencing to discover a new rare genetic disease.

15 Apr 2026

Identifying Somatic Driver Mutations in Thyroid Autoimmune Disease

According to recent studies, immune cell DNA mutations that eliminate the immune system's natural brakes may be the cause of autoimmune disorders.

15 Apr 2026

AI Predicts Viral Mutations to Design Future-Proof Vaccines

The wave-shaped chart Ratul Chowdhury pulls up on a computer monitor in his office captures the evolutionary cat-and-mouse game his research lab is up against.

13 Apr 2026

New Technology Uses Genetic Passcodes to Protect High-Value Engineered Cell Lines

In recent years, the Centers for Disease Control and Prevention, the Department of Homeland Security, and other authorities have flagged a record number of unauthorized shipments of biological materials.

11 Apr 2026

Single-Letter Insertion in Non-Coding DNA can Alter Sex Development in Mice

Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice.

11 Apr 2026

UTMB Researchers Develop AI Pipeline to Accelerate Pan-Alphavirus Vaccine Development

A team of scientists at The University of Texas Medical Branch (UTMB), led by Nikos Vasilakis, PhD, and Peter McCaffrey, MD, has developed a new computational pipeline that could dramatically accelerate the development of vaccines against a group of mosquito-borne viruses known as alphavirus.

11 Apr 2026

CU Boulder Study Shows Genetic Link Between Mental and Physical Illness

For centuries, mental illness and physical disease have been viewed as two distinct categories, each with its own field of study, its own doctors, and its own menu of treatments.

10 Apr 2026

Chemical Strategy Unlocks Pollutant Degradation Potential in Native Soil Bacteria

Aromatic compounds, such as dioxins and benzene, are major soil pollutants. Their high chemical stability makes them resistant to microbial and chemical degradation, leading to toxic accumulation in the soil.

10 Apr 2026

Genomic Study Maps the Biosynthesis of Dihydromyricetin in Vine Tea

Vine tea has been consumed in China for centuries and is valued as both a beverage and a medicinal plant.

10 Apr 2026

Vibrio cholerae Captures External DNA to Boost Its Antiviral Defenses

Like most bacteria, Vibrio cholerae lives under constant attack from viruses. To survive, bacteria equip themselves with antiviral immune systems.

10 Apr 2026

Non-Coding DNA Mutations Identified as Cause of Rare Neonatal Diabetes

Scientists have found new genetic causes for diabetes in babies – in a part of the genome that has historically been overlooked in genetic studies.

10 Apr 2026

Single-Cell Mapping Uncovers Insights Into Pregnancy Complications

The biological connection between a pregnant woman and her developing baby has been mapped in unprecedented detail by UC San Francisco scientists, revealing new cell types and insights into conditions such as preeclampsia, preterm birth, and miscarriage.

9 Apr 2026