Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

How Can Stressed Mitochondria Actually Protect Your Heart?

Mitochondria are popularly known as the “powerhouse of the cell,” but these cellular structures do so much more–including acting as signaling hubs.

9 Sep 2026

Salk Study Uncovers How Mitochondrial Signals Drive Lasting Cardioprotection

Mitochondria are popularly known as the "powerhouse of the cell," but these cellular structures do so much more-including acting as signaling hubs.

7 Sep 2026

Scientists Discover How Heart Muscle Cells Remodel Actin Filaments

Biophysicists unraveled a mystery of how muscles form at the molecular level and how they maintain their function.

30 Jul 2026

AI-Assisted Paper Test Measures Three Cardiac Biomarkers in 23 Minutes

Researchers developed an AI-assisted dual-mode paper assay that measures cTnI, CK-MB, and NT-proBNP from 50 µL of serum in 23 minutes. In single-site analytical validation, neural networks quantified the three biomarkers across distinct concentration ranges, supporting further development for multiplexed cardiac testing at the point of care.

27 Jul 2026

Female Hearts Rely on Molecular Safeguard to Avoid Failure

Men and women are not born with the same risk of heart disease, and for decades scientists have struggled to explain why. A new study from the University of North Carolina at Chapel Hill, published in Genes & Development, offers a striking answer: the female heart depends on a molecular safeguard that the male heart can largely do without - and when that safeguard is removed, female hearts fail while male hearts keep beating.

20 Jul 2026

Crucial X Chromosome Protein Protects Female Hearts From Fatal Failure

Men and women are not born with the same risk of heart disease, and for decades scientists have struggled to explain why.

17 Jul 2026

Building A Soft Robotic Heart That Mimics HFpEF Progression

Researchers developed a soft robotic heart model that replicates HFpEF, enhancing understanding of the disease and supporting innovative treatment strategies.

10 Jun 2026

Microtubule Skeleton Determines How Heart Muscle Cells Change Under Stress

Microtubules, part of heart muscle cells' internal "skeleton," help determine how the heart changes shape under stress, and a common signaling pathway called the ERK pathway acts as a key controller of where the building materials for these cells' growth are delivered inside them, a pair of new studies show.

9 Jun 2026

Syntax Bio Develops CRISPR Technology to Program Stem Cell Gene Activity

Syntax Bio, a synthetic biology company programming the next generation of cell therapies, today announced the publication of new research in Science Advances detailing the company's CRISPR-based Cellgorithm™ technology, which lays the groundwork for programmable control of gene activity in human stem cells and offers an alternative to the slow, variable manual processes researchers use today.

8 Dec 2025

Reactivating a Naturally Occurring Gene Promotes Heart Repair and Regeneration

A naturally occurring gene called Cyclin A2 (CCNA2), which turns off after birth in humans, can actually make new, functioning heart cells and help the heart repair itself from injury including a heart attack or heart failure when the gene is turned back on.

4 Nov 2025

MRI And 3D Printing Reveal How Artificial Hearts Manage Blood Flow

The integration of 4D flow MRI and 3D printing in TAH research offers vital insights into blood flow patterns, crucial for advancing heart failure therapies.

2 Oct 2025

Proteomic Signature in Blood Predicts Dementia and Diabetes Risk

A blood-based proteomic signature predicts healthspan, linking protein levels to disease risk and mortality, paving the way for targeted aging interventions.

10 Jun 2025

Super Stem Cells Offer New Hope for IVF and Regenerative Medicine

The ‘super stem cells’ perform better than regular stem cells, being able to develop into many different cell types, researchers from the University of Copenhagen find, with many potential applications, including improved IVF treatment.

25 Apr 2025

New Protein Identified as Regulator of Mitochondrial Calcium Transport

Calcium transport into and out of mitochondria – the powerhouses of cells – is central to cellular energy production and cell death.

9 Apr 2025

Digoxin Weakens Cancer’s Spread by Targeting Cell Clusters

Some tumor types spread throughout the body and develop metastases instead of staying at their original location.

27 Jan 2025

Microgravity Unlocks Secrets to Heart Cell Survival for Earth-Based Therapies

A team of researchers led by Emory's Chunhui Xu recently found that heart muscle cells can grow -and survive in the microgravity environment of space.

22 Jan 2025

Zebrafish Protein Promotes Cardiac Repair in Mice

Researchers from the Hubrecht Institute's Bakkers group have used a zebrafish protein to successfully repair damaged mouse hearts.

3 Jan 2025

Key Regulator of Heart Repair

UCLA researchers identified the protein GPNMB as a key regulator in the heart’s healing process following a heart attack.

28 Oct 2024

New Method Sheds Light on Bacterial Calcium Management

In human, animal, and plant cells, calcium ions play a crucial role as messengers. They support the regulation of essential functions like heartbeats, stress reactions, and nerve impulses.

15 Oct 2024