Metabolism News and Research

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Metabolism is the means by which the body derives energy and synthesizes the other molecules it needs from the fats, carbohydrates and proteins we eat as food, by enzymatic reactions helped by minerals and vitamins.

Experts Extend Lives of Animals By Activating ‘Energy Saver’ Mode

The study, published today in Aging Cell, found strong evidence that triggering a protein governing energy level may help organisms live longer, in some cases by over 25%.

1 Oct 2026

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors - which have transformed treatment for some cancers - benefit only 17%–23% of patients with head and neck squamous cell carcinoma. These are cancers that arise from cells lining the mouth, throat and voicebox.

1 Oct 2026

Kupffer Cells Increase Apolipoprotein Secretion in Response to Indigestible Plastics

Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These are the key findings from a joint German-Austrian study led by the University of Bonn, details of which have now been published in the journal "Nature Metabolism."

1 Oct 2026

Gut-Derived Neutral Ceramidase Regulates MASH Through Microbial and Epithelial Signaling

Metabolic dysfunction-associated steatohepatitis (MASH) is often viewed through the lens of hepatic lipid accumulation, inflammation and fibrosis.

30 Sep 2026

Single-Cell Sequencing Confirms Epigenetic Remodeling Across Diverse Cardiac Cell Types

The adult human heart is a reliable and resilient engine fueling our everyday lives while also being responsive enough to supercharge a Usain Bolt sprint or sustain a three-week bike race in the French Alps and Pyrenees.

29 Sep 2026

Scientists Pinpoint the Brain Circuit That Regulates Metabolism

As the body’s temperature decreases, it compensates by utilizing additional energy to produce heat and stimulating the desire to eat to replenish the energy expended for warmth.

28 Sep 2026

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

26 Sep 2026

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

Gut microbiota influences multiple aspects of host physiology, including metabolic and immune functions. Many metabolites produced by gut bacteria can cross the intestinal epithelium (which the bacteria may not be able to cross) and enter host tissues, providing a pathway through which microbial activity can influence host physiology.

25 Sep 2026

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

25 Sep 2026

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

25 Sep 2026

Scientists Discover Why High Levels of the Amino Acid Cysteine Are Toxic to Cells

Cysteine is one of the main building blocks that cells use to make proteins. But this amino acid is a double-edged sword–too much cysteine is toxic to the cell.

24 Sep 2026

Strength Training Induces Fat Breakdown in Obese Mice Without Weight Loss

Just seven days of strength training increased visceral fat burning in obese mice, even before any weight loss could be seen on a scale. In an experiment conducted at the State University of Campinas (UNICAMP), researchers observed that a short period of strength training activated mechanisms involved in fat breakdown, reduced fat cell size, and decreased fat around the animals' intestines.

23 Sep 2026

What Drives Pregnancy Cravings? Researchers Find a Clue in the Brain

What causes intense food cravings during pregnancy? Scientists at LSU’s Pennington Biomedical Research Center, working alongside collaborators, have pinpointed a neural mechanism that may explain how pregnancy influences the desire to pursue certain highly appealing foods.

22 Sep 2026

Blocking Mitochondrial Iron Transport Protects Cells Against Elevated Cysteine Toxicity

Cysteine is one of the main building blocks that cells use to make proteins.

22 Sep 2026

New Research Reveals Complex Protein Dynamics Within Human Red Blood Cells

They account for nearly 83% of all cells in the human body, yet red blood cells are often portrayed as little more than bags of hemoglobin ferrying oxygen from the lungs to the heart and beyond. But new research from the University of Colorado Anschutz reveals that they are vastly more complex with far reaching consequences for health, exercise and fitness.

21 Sep 2026

Restoring Gut Indole Levels Reduces Campylobacter Infection in Mouse Models

What if something produced naturally by your gut bacteria could help fight a dangerous foodborne pathogen?

17 Sep 2026

Noninvasive Imaging Framework Enhances Predictions of Higher-Order Human Brain Function

Researchers from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have developed a new, noninvasive way to examine how blood flow and cellular organization align across the layers of the living human brain.

17 Sep 2026

Molecular Circuit Linking Abscisic Acid Signaling to Tanshinone Production Uncovered

Salvia miltiorrhiza, also known as Danshen, is a highly regarded traditional Chinese medicine widely used for treating cardiovascular and cerebrovascular diseases. Its medicinal properties are largely attributed to tanshinones-a group of more than 40 diterpenoid quinone compounds, including tanshinone I, tanshinone IIA, and cryptotanshinone, which predominantly accumulate in the plant's roots.

11 Sep 2026

SMART Researchers Discover First PLP-Dependent Enzyme That Influences Bacterial Protein Production

Researchers from the Singapore-MIT Alliance for Research & Technology’s (SMART) Antimicrobial Resistance (AMR) interdisciplinary research group, alongside collaborators from Massachusetts Institute of Technology (MIT), Nanyang Technological University (NTU Singapore), and institutions in the United States, Poland, and France, have discovered aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress.

10 Sep 2026

Computational Chemistry Breakthrough Yields Targeted Molecule for Acute Myeloid Leukemia Treatment

Pushing the accelerator and the brake at the same time is rarely a good idea. But researchers at the University of Gothenburg are using this approach to treat leukemia.

9 Sep 2026

Metabolism News and Research

Experts Extend Lives of Animals By Activating ‘Energy Saver’ Mode

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Kupffer Cells Increase Apolipoprotein Secretion in Response to Indigestible Plastics

Gut-Derived Neutral Ceramidase Regulates MASH Through Microbial and Epithelial Signaling

Single-Cell Sequencing Confirms Epigenetic Remodeling Across Diverse Cardiac Cell Types

Scientists Pinpoint the Brain Circuit That Regulates Metabolism

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Scientists Discover Why High Levels of the Amino Acid Cysteine Are Toxic to Cells

Strength Training Induces Fat Breakdown in Obese Mice Without Weight Loss

What Drives Pregnancy Cravings? Researchers Find a Clue in the Brain

Blocking Mitochondrial Iron Transport Protects Cells Against Elevated Cysteine Toxicity

New Research Reveals Complex Protein Dynamics Within Human Red Blood Cells

Restoring Gut Indole Levels Reduces Campylobacter Infection in Mouse Models

Noninvasive Imaging Framework Enhances Predictions of Higher-Order Human Brain Function

Molecular Circuit Linking Abscisic Acid Signaling to Tanshinone Production Uncovered

SMART Researchers Discover First PLP-Dependent Enzyme That Influences Bacterial Protein Production

Computational Chemistry Breakthrough Yields Targeted Molecule for Acute Myeloid Leukemia Treatment

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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