Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Tireless Stem Cells Drive Continuous Renewal Across High Friction Human Intestines

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells. These stem cells can both replace the various types of intestinal cells that have been lost as well as renew themselves.

6 Aug 2026

Research Decodes How Gut Microbes Process Plant-Based Nutrients

Plant-based diets are good for you. They promote gut, immune, metabolic and cardiovascular health, in part by cultivating a diverse community of intestinal bacteria.

28 Jul 2026

Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate Cancer

Researchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells.

27 Jul 2026

New Research Links CALB2 Gene to Mechanoresistance in Metastatic Prostate Cancer

When a cancer cell leaves the original tumor to spread to a new, far away location, it first has to survive what most cells cannot: periodic high force moments in the vessels and heart of up to 5,000 dynes per centimeter squared as it circulates throughout the body.

24 Jul 2026

Global Breakthrough Maps Genes and Cells Regulating Bone Health

In a global breakthrough published in Nature Genetics, researchers have successfully mapped the cells and genes that regulate bone formation and loss at an unprecedented scale and discovered the critical role that blood vessel cells play in bone health.

11 Jul 2026

Gut Microbiome Signatures Correlate With Clinical Efficacy in Immunotherapy Outcomes

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

9 Jul 2026

Dying Bacterial Communities Eject Cells Just Like Sci-Fi Escape Pods

Popular science fiction is no stranger to escape pod scenarios, typically featuring characters who narrowly avoid their demise by jettisoning from a spaceship - think R2-D2 and C-3PO shooting away from a rebel spaceship in the opening of Star Wars: A New Hope.

7 Jul 2026

Cancer Cells Hijack Macrophage Metabolism to Create an Immunosuppressive Tumor Microenvironment

Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the tumor microenvironment. However, instead of attacking cancer cells, they are typically co-opted to support tumor growth, metastasis, and therapeutic resistance.

2 Jul 2026

Opposing Cellular States Collaborate Internally to Manage Vital Tissue Repair

Cellular senescence and stemness represent two biological entities with several opposing properties

30 Jun 2026

Advanced Bioinformatics Models Reveal Bacterial Function in Colon Cancer Patients

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

29 Jun 2026

New Genetic Discovery Explains Why Colorectal Cancer Spreads so Quickly

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology researchers.

23 Jun 2026

Single-Cell Analysis Uncovers How Cancer Tumors Diversify and Resist Treatment

A comprehensive multi-cancer study from researchers at The University of Texas MD Anderson Cancer Center has revealed that cancer cells within tumors are genetically diverse, yet all carry the same core genetic changes that can be traced back to a common ancestral cell, providing a single-cell view of how tumors adapt, survive and diversify. Understanding this helps explain why some cancer cells manage to survive treatments, paving the way for more tailored diagnostic and therapeutic strategies.

22 Jun 2026

Single Cell Tracking Explains Why Certain Cancer Cells Survive Treatments

17 Jun 2026

Researchers Outline Dynamic Protein Control Systems for Better Clinical Decisions

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

10 Jun 2026

Cell Phase Separation Creates Droplets That Optimize and Activate Kinase Signaling

Within the past decade, biologists have discovered that one strategy cells use to keep their contents organized is a phenomenon known as phase separation.

2 Jun 2026

Wireless Electric Fields Guide Immune Cells But Disorient Cancer Cells

Traditional electrotaxis assays place electrodes directly into the cell culture medium, which inevitably drives current through the sample.

27 May 2026

Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026

Aggressive Breast Cancer Cells Lose Spatial Persistence When Exposed to Wireless Electric Fields

Traditional electrotaxis assays place electrodes directly into the cell culture medium, which inevitably drives current through the sample.

26 May 2026

Genetic Engineering Creates an Immune System Cloak to Extend Bacterial Drug Circulation

While previous research from Johns Hopkins University is successfully completing clinical trials, University of Rhode Island College of Pharmacy Assistant Professor Kaitlin Dailey is expanding on that work to more specifically target tumors that are difficult or impossible to access, especially those associated with pancreatic cancer-one of the deadliest types.

21 May 2026

How the Microbiome Shapes Cancer Immunity and Therapy Response

This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.

29 Apr 2026