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DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Ingestible Bioprinter Revolutionizes Possibilities for Non-Invasive Tissue Repair

The MEDS device enables non-invasive tissue repair in the GI tract, utilizing innovative bioprinting techniques for effective treatment of internal lesions.

23 Oct 2025

Croatian Scientists Rewrite the Story of Cell Division

Scientists at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia, have discovered that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in fact plays a completely different role in chromosome movement.

22 Oct 2025

Understanding the Ecological Trap Threatening Winter-Ready Species

Even as autumn days grow shorter, a warming climate means Ohio winters aren't as cold as they were just a few decades ago, according to National Oceanic and Atmospheric Administration data.

10 Oct 2025

Intergenerational Transmission of Exercise Benefits Mediated by Sperm MicroRNAs

n a recent study published in Cell Metabolism, a collaborative research team led by Chen-Yu Zhang, Xi Chen, and Di-Jun Chen from Nanjing University, together with Tao Zhang from Nanjing Medical University, reported groundbreaking findings in their paper entitled "Paternal exercise confers endurance capacity to offspring through sperm microRNAs."

7 Oct 2025

Scientists Derive Authentic Embryonic Stem Cells From Chickens and Other Birds

Egg whites may be perfect for a health-conscious breakfast, but egg yolks turned out to be the key ingredient for cultivating bird embryonic stem cells (ESCs) in the lab.

30 Sep 2025

RyR1-Mediated CICR Plays Minimal Role in Normal Skeletal Muscle Contraction

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

26 Sep 2025

Discovery Reveals Spinal Neurons as Active Players in Sexual Behavior

For decades, it was thought that while the brain orchestrated male sexual behavior – arousal, courtship, and copulation – the spinal cord merely executed the final act: ejaculation. But a study from the Champalimaud Foundation (CF) challenges that tidy division.

25 Sep 2025

Engineered Base Editor Corrects ACTA2 Mutation in Rare Childhood Disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

13 Sep 2025

Fruit Fly Study Highlights Benefits of Heterogeneity Among Cells

All living beings, big or small, are formed through the hard work of many different cells. To keep the body ready for any challenge, cells need to be dynamic.

29 Aug 2025

Molecular Blueprint Reveals Structure and Delivery of Botulinum Toxin

Researchers at Stockholm University have succeeded in creating a molecular blueprint of how one of the world's most dangerous toxins, botulinum toxin, is structured, stabilized, delivered and released.

28 Aug 2025

Cryo-Optical Microscopy Captures Instantaneous Snapshots of Cellular Waves

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.

25 Aug 2025

Muscle Reprogramming Protein Found to Both Activate and Repress Genes

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

11 Aug 2025

Salk Scientists Use CRISPR to Uncover Microproteins Linked to Obesity

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

8 Aug 2025

Microglia Replacement Therapy Offers Hope for Genetic Disorders Affecting the Brain

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.

7 Aug 2025

Ribosome Levels Drop During Early Brain Development

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making proteins.

6 Aug 2025

Case Western Researchers Use Stem Cells to “Shut Off” Nerve Cell Strain

Amyotrophic lateral sclerosis (ALS), sometimes known as Lou Gehrig’s disease, is an incurable neurological disease that affects motor neurons, which are nerve cells in the brain and spinal cord that regulate voluntary muscle movement and breathing.

6 Aug 2025

New Genetic Research Reveals Hibernation Secrets Hidden in Human DNA

Animals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl.

1 Aug 2025

AgriLife Research Scientist Helps Crack Genome of a Soft Tick

Scientists at Texas A&M AgriLife Research and Baylor College of Medicine have sequenced the genome of the disease-spreading soft tick.

23 Jul 2025

Gene Editing Reverses Symptoms of Rare Brain Disorder in Mice

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

22 Jul 2025