Mutation News and Research

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Decoding the Molecular Logic of Histamine Signaling in the Brain

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses.

19 Jan 2026

New Pangenomic Approach Enables Unprecedented Scaling for Genetic Data

Researchers at the University of California have created a novel data structure and compression method that allows pangenomics to process genetic information at previously unattainable scales.

14 Jan 2026

Dual Genetic Mutations Drive RNA Mis-Splicing and Leukemia Progression

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations – IDH2 and SRSF2 – work cooperatively to mis-splice RNA messages and change how blood cells develop.

6 Jan 2026

AI-Powered Analysis Reveals How Gene Duplication Drives Plant Development

As global temperatures rise, Cold Spring Harbor Laboratory (CSHL) scientists work to grow stronger, more resilient crops. Yet, this process is challenging.

9 Dec 2025

Gene Transcription Start Sites Identified as Hidden Mutational Hotspots

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.

27 Nov 2025

Mitochondrial Mutation Found to Rewire Immune Function

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death.

27 Nov 2025

Scientists Uncover Inner Workings of Biomolecular Condensates Linked to ALS

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

27 Nov 2025

Cyanobacteria Change Their Genetic Activity After Sunset

Cyanobacteria, also referred to as blue-green algae, are found globally in diverse forms, encompassing both single-celled organisms and filamentous chains.

21 Nov 2025

Newly Identified Mitochondrial DNA Damage Sheds Light on Cellular Stress

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress.

20 Nov 2025

CRISPR Gene Editing Reverses Chemotherapy Resistance in Lung Cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth.

18 Nov 2025

Targeted Genetic Testing Revolutionizes Diagnosis of X-Linked Dystonia-Parkinsonism

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects primarily men of Filipino ancestry.

17 Nov 2025

Plant Cell Duality: Balancing Adaptability in Skin Cells with Stability in Reproductive Cells

Mutations drive evolution, but they can also be risky. New research led by plant biologists at the University of California, Davis, published Nov. 10 in Proceedings of the National Academy of Sciences, reveals how plants control mutation rates in different stem cells to balance adaptability with safety and stability.

13 Nov 2025

Uncovering the Mechanism of Chromosome Congression for Targeted Cancer Therapy

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell division.

11 Nov 2025

Researchers Find "Hidden" Mutations by Tracing Protein Isoforms

Approximately 25 million individuals in the United States are affected by a rare genetic disorder, and a significant number of them face challenges not only due to the absence of effective treatments but also because of insufficient information regarding their condition.

10 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

TRV-Mediated Gene Editing System Transforms Tomato Functional Genomics

CRISPR-Cas9 has revolutionized plant genome editing, yet its application in tomato remains limited due to the plant's recalcitrance to transformation and regeneration.

7 Nov 2025

Rapid Cell-Free Crystallization Method Reveals 3D Structures of Flexible Sugars

A quick, purification-free method was developed by researchers at Institute of Science Tokyo, to capture the detailed 3D structures of flexible sugar molecules.

31 Oct 2025

Protein Dysfunction Could be the Cause of Diseases Resulting From Shortened Telomeres

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Mutation in NAMPT Gene Found to Cause Rare Neurological Disease

An international research team, led by Shinghua Ding at the University of Missouri, has identified a previously unknown genetic disease that affects movement and muscle control.

28 Oct 2025

New Retron-Based Gene Editing Method Corrects Multiple Disease-Causing Mutations

Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person's genome, often with enough variation that even two individuals who share the same disorder might have a different combination of mutations.

24 Oct 2025