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New Understanding of Brain Circuitry Genes Opens Door for Targeted OCD Therapies

A Rutgers-led international team co-authored a study, which was published in Nature Neuroscience, revealing 36 genes significantly increasing the risk for obsessive-compulsive disorder (OCD) and chronic tic disorders. This research offers the most comprehensive biological insight into the development of these conditions and potential future treatments.

4 Sep 2026

New Human Blood Test Accurately Predicts Fatal ALS Neurological Progression

Amyotrophic lateral sclerosis (ALS) is a severe neurological disease that destroys nerve cells responsible for muscle movement. The disease typically begins with limb or bulbar weakness and progresses to respiratory failure.

31 Aug 2026

Bulky Molecular CRISPR Systems Barely Fit Inside Single Viral Vectors

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

31 Aug 2026

Colorectal Cancer and Nerve Damage: A Hidden Link Uncovered in Mice and Primates

Colorectal tumors trigger inflammatory nerve damage, suggesting cancer itself may be a risk factor for neuropathy in survivors, independent of treatments.

27 Aug 2026

Mutation Stalls Immature Brain Cell Maturation Leading to Aggressive Gliomas

Scientists at St. Jude Children's Research Hospital have shown that specific brain cells respond differently to the H3.3 K27M, a mutation in the histone H3.3 protein that drives many cases of diffuse midline glioma (DMG), depending on the cell's location in the developing brain.

27 Aug 2026

Reengineering Glial Cell Signaling Pathways to Slow Down ALS Symptoms

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.

21 Aug 2026

New Potential Target for Triple-Negative Breast Cancer

The study uncovers how macrophages recruit nerves in triple-negative breast cancer, suggesting BDNF signaling as a critical factor in tumor progression.

18 Aug 2026

Researchers Map Immune Molecule Behavior in Affected Motor Neurons

Immune-related molecules change in motor neurons affected by amyotrophic lateral sclerosis (ALS), but they do not appear to be major drivers of disease progression.

17 Aug 2026

Brain Executive Control Centers Block Creative Problem Solving in Mice

The prefrontal cortex, a brain region long associated with learning more flexible behaviors, can sometimes block the ability to think outside the box, a new study in mice shows. Science Advances published the finding by biologists at Emory University.

8 Aug 2026

Research Reevaluates Crucial Microtubule Stabilizing Protein in Dementia Progression

A protein named tau, which has been highly implicated in the world's No. 1 cause of dementia - Alzheimer's disease - and several other neurodegenerative disorders, may spur these diseases in a way that differs greatly from the pathological pathway usually ascribed to it.

7 Aug 2026

Emerging m6A RNA Biology Explains Brain Vulnerability to Environmental Hazards

A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease.

7 Aug 2026

Living Organisms Depend on Bacterial Production of Critical Vitamin B12

All living organisms need a little bit of it to form red blood cells and DNA, as well as to build and support brain and nerve cells. But it's hard to come by: Humans don't make it. Animals don't make it. Plants don't make it.

7 Aug 2026

Macrophages Release Brain Protein Beacon Drawing Nerves Into Breast Tumors

New research from the University of Oklahoma demonstrates how an aggressive form of breast cancer co-opts the body's own immune system to attract nerves that fuel tumor growth.

5 Aug 2026

Moth Wings Smell Host Plants to Identify Optimal Egg-Laying Spots

Insect wings are bristling with senses, feeling the wind blowing and even tasting potential mates, but little was known about whether moth wings are equipped with a sense of smell.

28 Jul 2026

Engineered Mice Carrying the Genetic Variant Develop Excessive Sweating

Johns Hopkins Medicine researchers have identified a genetic driver of primary idiopathic hyperhidrosis, a chronic condition that causes excessive sweating, providing some of the strongest evidence to date that the disorder can originate in the nervous system and may be treatable with targeted therapies.

22 Jul 2026

Bullfrog Protein Saxiphilin Acts as Effective Antidote for Marine Saxitoxin

The "red tide" algal blooms that are becoming more frequent along the Pacific coast produce one of the most potent neurotoxins known: saxitoxin, or STX.

17 Jul 2026

Innovative Bioelectronic Ear Devices Offer New Hope for Asthma Relief

Neuroimmunology, the study of interactions between the nervous and immune systems, is a rapidly growing field enabling new approaches for monitoring and treating inflammatory diseases.

16 Jul 2026

New Kinesin-1 Protein Maps Advance Treatment for Incurable Paralysis

A nerve cell resembles a vast tree with branches that communicate with thousands of other cells.

16 Jul 2026

Arc Protein Identified as Driving Tau Spread in Alzheimer's Disease

Arc's involvement in tau transmission via extracellular vesicles offers new understanding of Alzheimer's disease mechanisms and potential therapeutic pathways.

15 Jul 2026

Novel Study Reveals Hidden Biological Drivers Behind Cancer Induced Appetite Loss

Cachexia is a condition in which patients affected by cancer or other chronic diseases become sick and lose weight. The condition often involves brain-related symptoms of sickness, such as loss of appetite, which can lead to loss of muscle and often fat.

10 Jul 2026