Preclinical News and Research

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Unlocking Drug Discovery with SOAR's Innovative Resource

Northwestern's SOAR database enhances drug discovery by mapping gene activity, aiding researchers in identifying treatment targets and understanding diseases.

13 Jun 2025

Y Chromosome Loss Weakens Cancer Immunity

When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according to new findings from Cedars-Sinai investigators.

9 Jun 2025

Zebrafish Model Offers Hope for Treating Ultra-Rare Muscle Disease

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic disease is XMEA, which progressively weakens the muscles and can affect the liver and heart.

6 Jun 2025

Gene Editing Using CRISPR and AAV6 Impacts Long-Term Regeneration of Blood Stem Cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

4 Jun 2025

Exploring the Metabolic Pathways of Cancer Cells

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and lymphoma progression.

30 May 2025

Study Shows How Age-Related Metabolic Decline Impairs the Efficacy of CAR-T Cell Therapy

A Ludwig Cancer Research study has discovered that the metabolic decline that accompanies aging impairs the efficacy of CAR-T cell therapy, an immunotherapy in which T cells of the immune system are taken from patients, engineered to target cancer cells and reinfused into the same patients for treatment.

26 May 2025

Novel Molecule Inducing Ferroptosis for Metastatic Cancer Therapy

Scientists from Institut Curie, the CNRS, and Inserm have just created a novel class of molecules capable of destroying cancer cells that are resistant to current treatments and cause recurrence.

8 May 2025

Shift Work Impairs Muscle Clocks, Potentially Speeding Up Age-Related Decline

Muscle cells possess their circadian clocks, and research indicates that disrupting these clocks through shift work can significantly affect the aging process.

6 May 2025

New Compound Fights Superbug Gonorrhea via Toxin-Antitoxin System

In recent years, the World Health Organization (WHO) has consistently raised alarms regarding the rise of antibiotic-resistant microbes.

3 Apr 2025

Novel Synthetic Antibiotics Against Drug-Resistant Pathogens

Frogs have flourished for hundreds of millions of years, occupying nearly every habitat on Earth, from tropical rainforests to subarctic woodlands.

26 Mar 2025

Allegro’s Injectable Osteoarthritis Treatment Generates Positive Safety Results in Preclinical Studies

Allegro NV, a biomedical company developing transformative nanotechnology-based treatments for degenerative joint disease, has found that hydrocelin (ALG-001), its injectable microparticle hydrogel, showed no signs of toxicity in two preclinical studies conducted for periods of 4 and 13 weeks respectively.

25 Mar 2025

Researchers Identify Promising Drug Candidates for Previously “undruggable” Cancer Target

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein target, permanently blocking it.

21 Mar 2025

$30 Million Grant Supports AI-Powered Antibody Therapy Development

An ambitious project led by Vanderbilt University Medical Center investigators aims to use artificial intelligence technologies to generate antibody therapies against any antigen target of interest.

10 Mar 2025

Tumour-on-Chip Model Supports Preclinical Drug Development on Pancreatic Cancer

The biotech company Dynamic42, a specialist in organ-on-chip technology, has made a significant advance in pancreatic cancer drug research in collaboration with the research team of Prof. Dr. Nicole Teusch at the Institute of Pharmaceutical Biology and Biotechnology at Heinrich Heine University Düsseldorf.

7 Mar 2025

Minoryx Announces Dosing of the First Patient with Leriglitazone in the Phase 2a Study in Rett Syndrome (TREE Study)

Minoryx Therapeutics, a late-stage biotech company focused on the development of therapies for orphan central nervous system (CNS) disorders, today announces that the first patient in the TREE study has been dosed with leriglitazone.

6 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

Preclinical News and Research

Unlocking Drug Discovery with SOAR's Innovative Resource

Y Chromosome Loss Weakens Cancer Immunity

Zebrafish Model Offers Hope for Treating Ultra-Rare Muscle Disease

Gene Editing Using CRISPR and AAV6 Impacts Long-Term Regeneration of Blood Stem Cells

Exploring the Metabolic Pathways of Cancer Cells

Study Shows How Age-Related Metabolic Decline Impairs the Efficacy of CAR-T Cell Therapy

Novel Molecule Inducing Ferroptosis for Metastatic Cancer Therapy

Shift Work Impairs Muscle Clocks, Potentially Speeding Up Age-Related Decline

New Compound Fights Superbug Gonorrhea via Toxin-Antitoxin System

Novel Synthetic Antibiotics Against Drug-Resistant Pathogens

Allegro’s Injectable Osteoarthritis Treatment Generates Positive Safety Results in Preclinical Studies

Researchers Identify Promising Drug Candidates for Previously “undruggable” Cancer Target

$30 Million Grant Supports AI-Powered Antibody Therapy Development

Tumour-on-Chip Model Supports Preclinical Drug Development on Pancreatic Cancer

Minoryx Announces Dosing of the First Patient with Leriglitazone in the Phase 2a Study in Rett Syndrome (TREE Study)

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers Develop Mycobacteria Strains with Kill Switches for Safer TB Vaccines

CN Bio Introduces PhysioMimix DILI Assay Kit to Enhance Drug Safety Testing

CRISPR-Engineered Fat Cells Show Promise in Preclinical Cancer Models

Mitochondrial Calcium Imbalance Drives Neurodegeneration

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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