Preclinical News and Research

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Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

16 Oct 2026

Overcoming Bioprinting Challenges for Mature Adipocytes in 3D Tissue Models

Adipose tissue is a metabolically active organ involved in energy storage, endocrine signaling, and whole-body metabolic regulation.

15 Oct 2026

Comprehensive Analysis of Emerging Strategies for Targeting Cyclin-Dependent Kinases in Cancer

More than 30 years after the direct connection was established between the molecular machinery controlling cell division and cancer, a new paper traces the evolution of cyclin-dependent kinase research and outlines the next generation of CDK-targeted therapies.

15 Oct 2026

Orexo Reports Encouraging Bioavailability in First In Vivo Study of Oral Semaglutide Formulation Based on AmorphOX®

Orexo AB today announces promising initial results from its first preclinical pharmacokinetic in vivo study of an oral semaglutide tablet.

14 Oct 2026

New AI Model Decodes the Language of Immune Cell Movement

Researchers at The University of Texas MD Anderson Cancer Center and collaborating institutions in Texas developed an artificial intelligence (AI) model that helps explain how immune cells find their way to specific locations in the body and why they avoid others.

14 Oct 2026

Transcriptional Repression Mechanism Prevents Protective Immune Pathways From Triggering Autoimmunity

A preclinical study by researchers at UT Southwestern Medical Center has discovered how a protein called ZBTB44 helps prevent excessive immune activity that can cause inflammation in the colon, the main section of the large intestine. The findings, published in Nature Immunology, may help explain how immune responses go awry in a range of chronic inflammatory and autoimmune diseases

13 Oct 2026

A Pigment Found in Spinach Helped Build a Squeezable Heart Patch

The study reveals chlorophyll's role in creating highly compressible hydrogels, paving the way for advanced cardiac patches in minimally invasive surgeries.

7 Oct 2026

Knocking Out Specific Receptor Genes Prevents Dopaminergic Neuronal Cell Death

The protein alpha-synuclein is abundant in healthy brains and plays an important role in enabling communication between nerve cells.

6 Oct 2026

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Blocking USP15 in ovarian cancer cells disrupts growth and enhances chemotherapy sensitivity, revealing a potential target for overcoming treatment resistance.

1 Oct 2026

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

26 Sep 2026

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

25 Sep 2026

Type I Interferon Pathway Identified as Crucial Innate Viral Defense

Tick populations are expanding across the U.S., driving an increase in tick-borne diseases. Among them is Powassan virus, a rare but increasingly reported infection that can cause severe brain inflammation and lasting neurological complications.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Researchers Identify Peptide That Counters Key Processes of Neurodegenerative Disorders

Alzheimer's disease and related neurodegenerative disorders are among medicine's most challenging conditions, progressively impairing memory, movement and independence. Now, researchers at the University of California San Diego School of Medicine have identified a naturally occurring peptide - a small protein fragment called catestatin (CST) - that may help counter several key processes driving neurodegeneration.

23 Sep 2026

Preclinical News and Research

Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer

Overcoming Bioprinting Challenges for Mature Adipocytes in 3D Tissue Models

Comprehensive Analysis of Emerging Strategies for Targeting Cyclin-Dependent Kinases in Cancer

Orexo Reports Encouraging Bioavailability in First In Vivo Study of Oral Semaglutide Formulation Based on AmorphOX®

New AI Model Decodes the Language of Immune Cell Movement

Transcriptional Repression Mechanism Prevents Protective Immune Pathways From Triggering Autoimmunity

A Pigment Found in Spinach Helped Build a Squeezable Heart Patch

Knocking Out Specific Receptor Genes Prevents Dopaminergic Neuronal Cell Death

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

Type I Interferon Pathway Identified as Crucial Innate Viral Defense

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers Identify Peptide That Counters Key Processes of Neurodegenerative Disorders

UCLA Team Develops Advanced Immunotherapy to Fight Dangerous Arterial Plaques

Tumor Suppressor Pathways Remain Intact but Hyperactive During Progressive Tissue Aging

Obesity May Remove a Natural Defense Against Breast Cancer

Novel Organoid Platform Reveals Non-Immune Drivers of Diabetic Renal Injury

Activating TRPC1 Protein Channels With Magnetic Fields Triggers Cancer Phagocytosis

Reprogramming Tumor Immune Microenvironment to Combat Aggressive Glioblastoma Brain Cancer

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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