Preclinical News and Research

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Researchers Struggle Tracking Human Dementia Progress Using Traditional Laboratory Mice

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

31 Aug 2026

Primate-Specific DNA Change Reveals a New Link to Dementia-Related Neurodegeneration

29 Aug 2026

Next-Generation RNA Therapeutic Approach Offers Hope for Treating Diverse Genetic Diseases

Researchers at the University of Toronto have developed a next-generation RNA therapeutic approach with the potential to treat a wide range of genetic diseases that share certain disease-causing mutations.

28 Aug 2026

Novel T-Cell Engineering Strategy Prevents Deadly Osteosarcoma Lung Metastasis

Scientists at St. Jude Children's Research Hospital have discovered that removing the gene for Regnase-1 from engineered immune cells makes them more effective at treating relapsed osteosarcoma.

26 Aug 2026

New Hybrid Compounds Fight Aggressive Cancers and Infections

Cancer patients often face more than the disease itself. Their treatment is frequently complicated by infections and other health conditions, meaning they may need to take several different medications at once.

21 Aug 2026

Artificial Intelligence Methods for Predicting Drug-Target Interaction

Drug-target interaction prediction can help researchers explain mechanisms of action, identify candidate targets, reposition existing medicines and prioritize compounds before costly laboratory work.

21 Aug 2026

New Research Links Chronic Inflammation to Tumor Microenvironment Epigenetic Changes

Immune checkpoint inhibitors have revolutionized cancer treatment, yet many colorectal tumors remain resistant. Even among patients who initially respond, more than half eventually develop resistance, highlighting the need to better understand how tumors evade immune attack.

19 Aug 2026

McMaster Team Identifies Natural Immune Defense Against Advanced Fatty Liver Disease

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signaling pathway, opening new possibilities for treating advanced fatty liver disease.

11 Aug 2026

Decoding Brown Rat Pangenomes Provides Accurate Blueprints for Human Illness

Researchers have created the most complete genetic profile of the brown rat to date, according to a UTHealth Houston-led team, paving the way for scientists to more accurately research the genetic links to conditions like heart disease, kidney disease, high blood pressure, and stroke.

8 Aug 2026

Localized Biochemical Halos Shield Pancreatic Beta Cells From Rejection

A protein known as interleukin 10 (IL-10) is the lynchpin of a new method to protect transplanted cells from host immune system aggression.

6 Aug 2026

Newly Identified Protein Prevents T Cells From Destroying Cancer Cells

Researchers at Mayo Clinic have identified a protein that cancer cells use to suppress the body's immune response, a finding that could support the development of new treatments to improve the effectiveness of cancer immunotherapies.

5 Aug 2026

Natural Product Derivatives Show High Potency Against Drug-Resistant Malaria Strains

Parasites are becoming highly resistant to existing drugs, and hence scientists at the University of California, Riverside are developing new drugs for the two major parasitic infectious diseases—babesiosis and malaria.

3 Aug 2026

T Cells Identify Dangerous Pathogenic Threats to Keep Bodies Healthy

Your body depends on T cells to stay healthy. These white blood cells act like a neighborhood watch in the body, helping the immune system spot threats such as viruses, bacteria, and cancer cells.

3 Aug 2026

Uncovering New Pathological Pathways Behind Sepsis Triggered Circulatory Failure Risks

Sepsis triggers widespread inflammation, circulatory failure and metabolic stress, and cardiac dysfunction is a common complication associated with sharply poorer outcomes.

3 Aug 2026

Innovative SenMayo Gene Set Consistently Identifies Diverse Senescent Cells

A series of seven Mayo Clinic studies is helping reshape scientists' understanding of senescent, or "zombie," cells - aging cells that no longer divide but remain metabolically active and release inflammatory molecules that contribute to age-related diseases.

31 Jul 2026

Microneedle Patches Turn Skin Into a Window for Immune Bioanalysis

Researchers combined local restimulation of skin-resident memory T cells with hydrogel-coated microneedle patches to recruit and sample rare immune cells. In mouse models, the approach recovered more antigen-specific T cells than a blood sample or punch biopsy, while studies in humans supported short-term tolerability and proof-of-concept cell sampling.

28 Jul 2026

Novel Dendritic Cell Vaccine Redirects Viral Memory to Fight Tumors

In a discovery that could redefine the future of cancer immunotherapy, scientists from Celloram Inc., University Hospitals and Case Western Reserve University have developed a novel cancer vaccine platform that transforms the impact of the largest immunological event in modern history

28 Jul 2026

Engineered Probiotic Bacteria Deliver Immune Therapy Directly Into Pancreatic Tumors

Cancer immunotherapies have transformed treatment for many cancers, but pancreatic cancer remains especially difficult to treat. One major reason is that pancreatic tumors often create a "cold" tumor microenvironment, where the tumor prevents immune cells from mounting a strong attack.

27 Jul 2026

Kobe University Unveils Mass-Producible Off-the-Shelf Cancer Fighters

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

24 Jul 2026

Study Identifies Immune Cell Failures as Aging Drivers

We may age at different rates, but none of us escapes aging.

17 Jul 2026

Preclinical News and Research

Researchers Struggle Tracking Human Dementia Progress Using Traditional Laboratory Mice

Primate-Specific DNA Change Reveals a New Link to Dementia-Related Neurodegeneration

Next-Generation RNA Therapeutic Approach Offers Hope for Treating Diverse Genetic Diseases

Novel T-Cell Engineering Strategy Prevents Deadly Osteosarcoma Lung Metastasis

New Hybrid Compounds Fight Aggressive Cancers and Infections

Artificial Intelligence Methods for Predicting Drug-Target Interaction

New Research Links Chronic Inflammation to Tumor Microenvironment Epigenetic Changes

McMaster Team Identifies Natural Immune Defense Against Advanced Fatty Liver Disease

Decoding Brown Rat Pangenomes Provides Accurate Blueprints for Human Illness

Localized Biochemical Halos Shield Pancreatic Beta Cells From Rejection

Newly Identified Protein Prevents T Cells From Destroying Cancer Cells

Natural Product Derivatives Show High Potency Against Drug-Resistant Malaria Strains

T Cells Identify Dangerous Pathogenic Threats to Keep Bodies Healthy

Uncovering New Pathological Pathways Behind Sepsis Triggered Circulatory Failure Risks

Innovative SenMayo Gene Set Consistently Identifies Diverse Senescent Cells

Microneedle Patches Turn Skin Into a Window for Immune Bioanalysis

Novel Dendritic Cell Vaccine Redirects Viral Memory to Fight Tumors

Engineered Probiotic Bacteria Deliver Immune Therapy Directly Into Pancreatic Tumors

Kobe University Unveils Mass-Producible Off-the-Shelf Cancer Fighters

Study Identifies Immune Cell Failures as Aging Drivers

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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