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Researchers Develop 3D Organoids that Reflect the Complexity of Brain Tumors

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

16 Apr 2026

New Experimental System Mimics Low-Grade Pediatric Glioma in 3D

A three-dimensional experimental system has been developed to study the response to drugs in low-grade glioma, a tumor of the central nervous system that often occurs in children.

10 Apr 2026

Semen-Derived Exosomes Eye Drops to Treat Retinoblastoma

Innovative eye drops using semen-derived exosomes target retinoblastoma, improving therapeutic delivery and preserving ocular function in preclinical models.

8 Apr 2026

New Mouse Model Reveals Viral Path to Liver Cancer

Liver cancer is one of the world's deadliest cancers, and most cases are linked to chronic viral hepatitis. Yet scientists have lacked an animal model that faithfully recapitulates how the disease unfolds in people, from initial infection with a virus to liver inflammation, scarring, and cancer.

7 Apr 2026

Tumors Disable Dendritic Cells by Decreasing Mitochondrial Fitness

St. Jude Children's Research Hospital scientists have discovered how tumors disable immune "gatekeeper" cells that alert the rest of the immune system to the presence of cancer - and how restoring their energy production can improve immunotherapy.

3 Apr 2026

Defining Tumor Microbiota for Improved Cancer Diagnosis and Treatment

Recent research shows that tumors in different organs host microbial communities capable of influencing cancer biology, immune responses, and the effectiveness of therapies, highlighting the need to standardize methods for studying intratumoral microbes.

3 Apr 2026

Regenerative Vascular Grafts Solve Key Shortage In Surgery

Engineered biotubes demonstrate strong mechanical performance and rapid tissue regeneration, offering a scalable solution to the vascular graft shortage.

2 Apr 2026

A Python-Inspired Molecule Suppresses Appetite After Eating

The study identifies pTOS as a key metabolite in appetite suppression, highlighting a gut–liver–brain pathway with implications for obesity therapy.

2 Apr 2026

Novel Immunotherapy Disrupts the Protective Tumor Microenvironment Ecosystem

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: tumor cells often don't share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

31 Mar 2026

New Mechanism Links Mitochondria Dysfunction to T Cell Exhaustion

The immune system's killer T cells do a commendable job of detecting and destroying cancer cells. But the harsh environment at the heart of tumors often saps them of their vitality, pushing them into a state of permanent lassitude called "terminal exhaustion."

23 Mar 2026

Psoriasis-Like Inflammation Limits Skin Cancer Growth

A study shows that psoriasis-like immune responses may limit skin cancer growth, challenging the view of chronic inflammation as solely tumor-promoting.

19 Mar 2026

EV Engineering Boosts Drug Delivery and Improves Sepsis Survival

The engineered scaffold protein EN144 significantly improves extracellular vesicle therapies, showing potential in sepsis treatment and targeted drug delivery.

18 Mar 2026

Unexpected SRC Localization Offers Promising Target for Cancer Therapies

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.

16 Mar 2026

Study Reveals How Altering Cancer’s Protein Machinery Stimulates Antitumor Immunity

A new study led by Pierre Close's team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response.

12 Mar 2026

Genetically Engineered Stem Cells Successfully Overcome Immune Rejection in Mice

A study published today in Stem Cell Reports demonstrates that genetically engineered human pluripotent stem cells (hPSCs) can overcome immune rejection in mice with humanized immune systems, surviving for five months in a stringent transplantation model.

6 Mar 2026

Transplanted Mitochondria Enhance Cell Metabolism and Survival Under Stress

Mitochondria, also known as the powerhouses of the cell, are essential for cell survival, repair, and adaptation.

5 Mar 2026

Tirzepatide Reduces Alcohol Drinking And Relapse In Preclinical Study

Tirzepatide alters brain reward signaling and reduces alcohol intake in rodents, indicating its potential as a therapeutic option for alcohol use disorder.

4 Mar 2026

Research Shows Successful Recovery of Antigen-Specific T Cells in Mouse Models

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.

3 Mar 2026

Macrophages Offer a Safer Alternative to CAR-T Therapies with Lower Toxicity

A new study from researchers at Wake Forest University School of Medicine has identified a promising strategy to treat brain metastases, one of the most challenging and deadly complications of lung cancer.

3 Mar 2026

Engineered CD4 CAR T Cells Reduce Amyloid Plaques in Alzheimer’s

Findings suggest engineered CD4+ T cells can modify Alzheimer's pathology and improve CNS immune responses, highlighting a novel therapeutic approach.

19 Feb 2026