Preclinical News and Research

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Antibody-Based Strategy Makes Stem Cell Transplants Safer

Stem cell transplantation (also called bone marrow transplantation) and gene therapy are among the most powerful curative approaches for blood diseases such as sickle cell disease, b-thalassemia, immune deficiencies, and some blood cancers.

9 Jul 2026

Study Identifies Novel Metabolic Pathway Driving Cancer Gene Activation

A team at Roswell Park Comprehensive Cancer Center has identified a novel metabolic pathway that plays a key role in enabling cancer to progress through gene activation.

9 Jul 2026

Gut Bacteria Actively Manage Vitamin A Delivery for T Cell Maturation

Scientists at UT Southwestern Medical Center have discovered that gut bacteria help regulate the development of the body's immune system by directing the movement of vitamin A through a previously unrecognized cellular network.

8 Jul 2026

Study: Genetically Engineered CAR T Cells Suppress the Immune System’s Response to Allergen

Genetically engineered CAR T cells expressing artificial receptor proteins are increasingly used in the clinic to boost the immune system's response against leukemias and other cancers.

7 Jul 2026

Synthetic Organizer Cells To Build More Realistic Kidney Organoids

In research published in Science, USC researchers combined a biological finding with an engineering achievement to produce organoids—lab-grown kidney structures derived from stem cells—that are more faithful and reproducible.

3 Jul 2026

Researchers Discover Genetic Markers Predicting Prostate Cancer Ferroptosis

A new study from researchers at The University of Texas MD Anderson Cancer Center has identified genetic factors that determine whether prostate cancers are susceptible to a type of cell death known as ferroptosis.

3 Jul 2026

Melatonin Enhances Random Skin Flap Viability by Suppressing Ferroptosis

Random-pattern skin flaps are widely used to repair defects caused by trauma, burns, tumor removal, and other injuries because they can be designed without depending on a single named blood vessel.

29 Jun 2026

New Research Identifies Molecular Switch for Disfiguring Hypertrophic Skin Scars

A research team has uncovered a cellular and molecular mechanism that may help explain why some wounds develop into hypertrophic scars, the raised and often rigid scars that can cause itching, pain, disfigurement, and restricted movement.

26 Jun 2026

New Genetic Discovery Explains Why Colorectal Cancer Spreads so Quickly

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology researchers.

23 Jun 2026

Scripps Research Identifies Erucamide Molecule as Shield Against Blindness

Many conditions that cause vision loss share a common feature: the gradual breakdown of the retina, the light-sensing tissue at the back of the eye.

23 Jun 2026

Indiana University Study Identifies New Pathway to Combat Leukemia

Indiana University School of Medicine cancer researchers have identified a potential way to use existing, accessible drugs to combat juvenile myelomonocytic leukemia (JMML) by targeting a specific inflammatory pathway.

19 Jun 2026

Advanced Bladder Cancer Spatial Mapping Identifies Diverse Cellular Tumor States

Researchers at The University of Texas MD Anderson Cancer Center have developed a spatial map of muscle-invasive bladder cancer, revealing how tumor cell states, immune environments and therapeutic vulnerabilities are organized within tumors.

19 Jun 2026

Collaborative Research Discovers New Treatments for Alzheimer' Disease

A new multimillion-dollar project will bring together researchers from the Indiana University School of Medicine and the IU Luddy School of Informatics, Computing, and Engineering as they work to solve one of medical science's greatest needs: Identifying new treatments for Alzheimer's disease and related dementias.

16 Jun 2026

New Gene-Editing Strategy Ensures Quality Control in Stem Cell Therapies

A team of researchers led by Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) has developed a new strategy to significantly improve the precision and safety of CRISPR-Cas9 gene editing.

3 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Introducing Evosep Proteomics to Standardize and Scale Proteomics for Research and Drug Development

Evosep announces the launch of Evosep Proteomics, an ecosystem designed to standardize and scale LC-MS-based proteomics for research and pharmaceutical drug development.

From Evosep 2 Jun 2026

Nanoparticles Boost Delivery of Lung Cancer Drugs 30-Fold

Lung cancer remains one of the world’s deadliest cancers, yet despite decades of effort to develop new drugs, many fail because they don’t stay in the body long enough to be effective or because they damage healthy organs.

1 Jun 2026

MRM Health Rewarded a € 2.6 M VLAIO Research Grant to Accelerate the Development of Novel Therapeutics that Redefine the Treatment of Immune-Mediated Inflammatory Diseases

MRM Health, a clinical-stage biopharmaceutical company developing therapeutics for immune-mediated diseases, which unlock the power of the microbiome to restore immune balance, today announced that it has been awarded a research grant of € 2.6M from Flanders Innovation and Entrepreneurship (VLAIO), a government organization with the goal to stimulate economic development in Flanders, Belgium.

29 May 2026

Macrophage Placement Determines if Tumors Thrive or Regress

Cancer tumors are surrounded by immune cells, but not all of those cells help the body fight back. Some support anti-cancer immunity, while others can unexpectedly help tumors survive.

27 May 2026

Ovarian Cancer Fluid Helps Tumors Evade Cell Death

Ascites in ovarian cancer rewires tumor metabolism, protecting cells from ferroptosis and promoting metastasis, revealing potential therapeutic targets.

27 May 2026