Preclinical News and Research

RSS

New Mechanism Links Mitochondria Dysfunction to T Cell Exhaustion

The immune system's killer T cells do a commendable job of detecting and destroying cancer cells. But the harsh environment at the heart of tumors often saps them of their vitality, pushing them into a state of permanent lassitude called "terminal exhaustion."

23 Mar 2026

Psoriasis-Like Inflammation Limits Skin Cancer Growth

A study shows that psoriasis-like immune responses may limit skin cancer growth, challenging the view of chronic inflammation as solely tumor-promoting.

19 Mar 2026

EV Engineering Boosts Drug Delivery and Improves Sepsis Survival

The engineered scaffold protein EN144 significantly improves extracellular vesicle therapies, showing potential in sepsis treatment and targeted drug delivery.

18 Mar 2026

Unexpected SRC Localization Offers Promising Target for Cancer Therapies

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.

16 Mar 2026

Study Reveals How Altering Cancer’s Protein Machinery Stimulates Antitumor Immunity

A new study led by Pierre Close's team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response.

12 Mar 2026

Genetically Engineered Stem Cells Successfully Overcome Immune Rejection in Mice

A study published today in Stem Cell Reports demonstrates that genetically engineered human pluripotent stem cells (hPSCs) can overcome immune rejection in mice with humanized immune systems, surviving for five months in a stringent transplantation model.

6 Mar 2026

Transplanted Mitochondria Enhance Cell Metabolism and Survival Under Stress

Mitochondria, also known as the powerhouses of the cell, are essential for cell survival, repair, and adaptation.

5 Mar 2026

Tirzepatide Reduces Alcohol Drinking And Relapse In Preclinical Study

Tirzepatide alters brain reward signaling and reduces alcohol intake in rodents, indicating its potential as a therapeutic option for alcohol use disorder.

4 Mar 2026

Research Shows Successful Recovery of Antigen-Specific T Cells in Mouse Models

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.

3 Mar 2026

Macrophages Offer a Safer Alternative to CAR-T Therapies with Lower Toxicity

A new study from researchers at Wake Forest University School of Medicine has identified a promising strategy to treat brain metastases, one of the most challenging and deadly complications of lung cancer.

3 Mar 2026

Engineered CD4 CAR T Cells Reduce Amyloid Plaques in Alzheimer’s

Findings suggest engineered CD4+ T cells can modify Alzheimer's pathology and improve CNS immune responses, highlighting a novel therapeutic approach.

19 Feb 2026

Early Brain Development May Predispose Some People to Obesity

Researchers at UT Southwestern Medical Center have revealed that a critical developmental process in the brain's hypothalamus might influence an individual's vulnerability to obesity.

18 Feb 2026

Human 3D Model Shows How the Gut Drives Neurodegeneration

Research on a 3D microfluidic model highlights gut-brain interactions, offering new insights into inflammatory processes linked to neurodegenerative diseases.

18 Feb 2026

Uncoupling Nucleotide Synthesis: A Yeast-Derived Solution for Mitochondrial Disease

Nucleotide synthesis-the production of the basic components of DNA and RNA-is essential for cell growth and division.

17 Feb 2026

Bone-building hormone eases chronic low back pain by restoring vertebral microarchitecture

Parathyroid hormone shows promise in treating low back pain by remodeling degenerating vertebral endplates and limiting pathological sensory innervation.

12 Feb 2026

Novel Hydrogel Stops Infection and Speeds Wound Recovery

A novel gel might help combat resistant bacteria in wounds and around implant sites while also promoting recovery. The hydrogel, which is inspired by natural immune defenses, has generated extremely encouraging outcomes in animal models.

4 Feb 2026

Gravity-Driven Microfluidic Platform Enhances Immune Cell-Tissue Co-Culture

Advanced in vitro models such as organ-on-chip systems aim to replicate human physiology more accurately than conventional cell cultures. However, most existing platforms struggle to incorporate circulating cells like immune cells or circulating tumor cells.

3 Feb 2026

Gut Microbial Metabolite Hippuric Acid Amplifies Immune Responses

Scientists at The Wistar Institute have identified a previously overlooked mediator in the body's response to life-threatening infections: hippuric acid, a metabolite produced when gut bacteria break down polyphenols from berries, tea, and other plant-based foods.

31 Jan 2026

Backyard Soil Bacterium Produces Antibiotic Built to Outsmart Resistance

Early in 2025, scientists discovered a promising new antibiotic in a soil sample from a lab technician's backyard.

16 Jan 2026

Turning Human Fat into Insulin-Producing Organoids That Reverse Diabetes

By preserving fat tissue architecture, researchers created organoids that restore insulin function, paving the way for advancements in diabetes treatment.

8 Jan 2026