Signaling Pathway News and Research

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Uncovering the Molecular Networks Governing Signal Crosstalk Inside Complex Plant Cells

Cells rely on complex signaling networks in which different molecular pathways communicate with one another. Small GTPases act as molecular switches in these networks, controlling diverse cellular processes such as intracellular transport and cell morphogenesis.

18 Sep 2026

Uncovering B Cell Signaling Pathways to Enhance Targeted T Cell Immunotherapies

Cancer is the second leading cause of death in the United States, according to a 2026 Cancer Research Institute report. Cancer biologists are keenly aware of this statistic, as it drives them to innovations that revolutionize cancer care-innovations like immunotherapy.

17 Sep 2026

Research Exposes Molecular Mechanisms Dampening CD8+ T Cell Functional Efficacy

A research team led by Prof. ZHOU Xuyu from the Institute of Microbiology of the Chinese Academy of Sciences (CAS), in collaboration with researchers from Beijing Ditan Hospital and Capital Medical University, has identified ANKRD11 as a key regulator that reduces the activity of CD8+ T cells during chronic hepatitis B virus (HBV) infection and cancer.

15 Sep 2026

Elusive Archaea Act as Flexitarians in Marine Sponge Symbiosis

Symbiotic ammonia-oxidizing archaea in marine sponges are not strict specialists, but true "flexitarians": A team led by microbiologists Bettina Glasl and Katharina Kitzinger from the University of Vienna, in collaboration with partners from Australia, has shown that these microbes dine not only on ammonia but also on amino acids such as valine, leucine, and isoleucine - and presumably do that to communicate with their animal host.

7 Sep 2026

Single-Cell Study Decodes Ancient Plant Partnership With Soil Fungi

Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi.

19 Aug 2026

New Potential Target for Triple-Negative Breast Cancer

The study uncovers how macrophages recruit nerves in triple-negative breast cancer, suggesting BDNF signaling as a critical factor in tumor progression.

18 Aug 2026

Study Reveals Why People Are At Greater Risk of Fungal Infections Than Others

A study on Candida albicans uncovers immune mechanisms that prevent systemic infections, emphasizing the role of IL-1 cytokines and neutrophil response.

13 Aug 2026

Transition From Milk to Solid Food Shapes Immune System Development

The early period of life is a critical phase in which the immune system must learn to tolerate harmless environmental stimuli, such as food and microbes that normally live in and on the body, while remaining vigilant against harmful substances and pathogens.

12 Aug 2026

McMaster Team Identifies Natural Immune Defense Against Advanced Fatty Liver Disease

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signaling pathway, opening new possibilities for treating advanced fatty liver disease.

11 Aug 2026

Mapping Alternative RNA Splice Isoforms to Identify Novel Therapeutic Targets

Proteogenomics represents a transformative approach in cancer research that bridges the gap between genomic alterations and their functional consequences at the protein level.

8 Aug 2026

Protein Discovery Sheds Light on Scarring Diseases

UK and US scientists have uncovered an important piece of the puzzle on the signaling pathway that causes damaging scar tissue to build up in the body, raising hopes for future treatments.

5 Aug 2026

Structural Proteins Control Stem Cell Division to Stop Tissue Tumors

In many animal tissues, stem cells continually divide to create new cells that replace old or damaged ones. However, this capacity requires strict regulation, as uncontrolled stem cell proliferation can disrupt tissue homeostasis and contribute to tumorigenesis.

29 Jul 2026

Study Uncovers Two Distinct Embryonic Macrophage Populations with Different Repair Abilities

In leukemia's most aggressive forms, the blood cell factories in our bone marrow falter. Instead of dividing and multiplying at their usual prolific pace, generating hundreds of billions of new cells daily, some precursor cells stall out at an immature stage.

27 Jul 2026

Bio-Techne Launches Expanded R&D Systems AI-Engineered Designer Protein Portfolio

Bio-Techne Corporation, a global provider of life science tools, reagents, and diagnostic products, today announced the launch of new additions to its R&D Systems™ AI-Engineered Designer Protein portfolio, designed to improve reproducibility and performance across advanced cell culture and cell therapy development workflows.

From Bio-Techne 8 Jul 2026

Research Links Evolved Long Noncoding RNAs to Cancer Growth

In cancer research, one person's junk is increasingly becoming another person's treasure. Scientists have now uncovered new evidence showing how recently evolved "junk DNA" genetic elements can become integrated into ancient cellular pathways that regulate cancer.

2 Jul 2026

Research Links Bifidobacterium animalis Metabolites to Improved Anti-Tumor T Cell Immunity

Immune checkpoint inhibitors like anti-PD-1 have transformed melanoma treatment, yet more than half of patients fail to respond or eventually develop resistance. The tumor microenvironment and the gut microbiome are increasingly recognized as critical determinants of immunotherapy outcomes.

2 Jul 2026

Researchers Identify a Dedicated Gut-Brain Signaling Pathway That Helps Drive Hunger

Researchers at the Monell Chemical Senses Center found that common dietary sugars fructose and glucose, despite having the same amount of calories, communicate with the brain through different gut-brain pathways, a difference that may help shape our food and beverage preferences.

12 Jun 2026

Microtubule Skeleton Determines How Heart Muscle Cells Change Under Stress

Microtubules, part of heart muscle cells' internal "skeleton," help determine how the heart changes shape under stress, and a common signaling pathway called the ERK pathway acts as a key controller of where the building materials for these cells' growth are delivered inside them, a pair of new studies show.

9 Jun 2026

Bispecific Antibodies Target Tumors While Sparing Healthy Tissue

A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

3 Jun 2026

Cell Phase Separation Creates Droplets That Optimize and Activate Kinase Signaling

Within the past decade, biologists have discovered that one strategy cells use to keep their contents organized is a phenomenon known as phase separation.

2 Jun 2026