therapeutics News and Research

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DHPS Enzyme Deficiency Impairs Macrophage Development and Tissue Repair

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health found that an enzyme involved in protein translation is essential for circulating immune cells, called monocytes, to mature into tissue-resident macrophages, a specialized population of immune cells that maintain organ health by clearing dead cells and debris.

22 Jan 2026

First Fully Synthetic Bacteriophage Engineering System for Antibiotic-Resistant Bacterium

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century.

21 Jan 2026

Mapping the Human E3 Ligase Landscape

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.

19 Jan 2026

Immune Cell Atlas of Multiple Myeloma Could Guide Future Treatment Strategies

Scientists at the Icahn School of Medicine at Mount Sinai, in partnership with the Multiple Myeloma Research Foundation (MMRF) and in collaboration with leading institutions across the country, have helped generate the largest single-cell immune cell atlas of the bone marrow in patients with multiple myeloma, a blood cancer that, while treatable, remains incurable.

12 Jan 2026

Unusual Antibody Tactics Hinder Pathogen Attachment to Cells

Pathogens can create sticky situations. When microbes invade the body to cause an infection, often one of their first lines of attack is to cling tenaciously to the surfaces of targeted human cells.

8 Jan 2026

Microneedle Patches May Unlock Safer, Localized Cancer Immunotherapy

This review highlights the potential of natural polysaccharide microneedles in cancer immunotherapy, focusing on localized treatment and immune activation.

7 Jan 2026

New CHANGE-seq-BE Method Sharpens Safety Assessment of CRISPR Base Editors

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St. Jude Children's Research Hospital.

5 Jan 2026

Protein MCL1 Emerges as a Central Regulator of Cancer Metabolism

The researchers have succeeded in tracing two classic hallmarks of cancer – the evasion of apoptosis (a form of programmed cell death) and the dysregulation of energy metabolism – back to a common molecular mechanism.

23 Dec 2025

Study Identifies Protein Target to Overcome Drug Resistance in NSCLC

Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States.

22 Dec 2025

Condensates Introduce a New Paradigm in Cellular Bioelectricity

Many biological processes are regulated by electricity-from nerve impulses to heartbeats to the movement of molecules in and out of cells.

19 Dec 2025

CRISPR Reveals Dark Genome Regions That Sense Cellular Mechanics

Researchers at Duke University used CRISPR technologies to discover previously unannotated stretches of DNA in the 'dark genome' that are responsible for controlling how cells sense and respond to the mechanical properties of their local environment.

12 Dec 2025

OIST Study Illuminates Cancer's Avoidance of Cellular Stress Responses

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

11 Dec 2025

Researchers Capture the Most Detailed Images of Molecules in Chromatin Condensates

A team of researchers led by HHMI Investigator Michael Rosen has captured the most detailed images yet of the molecules in chromatin condensates — droplet-like structures of compacted DNA.

5 Dec 2025

Study Reveals How Cells Compensate for Missing Chromosomes

A hallmark of cancerous cells is an abnormal number of chromosomes or chromosome arms, known as aneuploidy.

4 Dec 2025

Decoding the Interaction Between SV2A Protein and Anti-Epileptic Drugs

A multi-institute team led by St. Jude Children's Research Hospital and UT Southwestern Medical Center investigators established for the first time how certain drugs used to treat epilepsy affect their target.

2 Dec 2025

Unraveling How GFAP Mutations Disrupt Mitochondria in Alexander Disease

Some brain disorders are straightforward, such as the direct frontal lobe assault of a concussion or traumatic brain injury. Others, like Alexander disease, are akin to guerilla warfare.

2 Dec 2025

Capturing a Self-Splicing Ribozyme in Motion

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

28 Nov 2025

Real-Time Visualization Reveals the Transcriptional Gearbox

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

28 Nov 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025

Old Blood Stem Cells Regain Regenerative Capacity Through Lysosomal Intervention

Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell's lysosomes.

25 Nov 2025