therapeutics News and Research

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Cysteine Pathways Shape T Cell Expansion and Cancer Defense

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health have discovered how the immune system's CD8+ T cells use the nutrient cysteine to control two essential functions that compete for this resource - the immune cell's ability to multiply and its ability to kill cancer cells.

1 Apr 2026

Tick-Borne Parasite Treatment Benefits From Replacing Infected Red Cells

In a multicenter study, researchers at Mass General Brigham found that exchange transfusion was associated with markedly improved outcomes compared with standard treatment for a potentially life-threatening tick-borne infection

31 Mar 2026

Novel Immunotherapy Disrupts the Protective Tumor Microenvironment Ecosystem

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: tumor cells often don't share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

31 Mar 2026

New Technology Enables Whole-Body Analysis of Gene Expression

Understanding gene expression within the body has been a boon for 21st century biology and therapeutics, but most discoveries that use these technologies only focus on one organ or one small area of tissue.

30 Mar 2026

Study Reveals How STING Protein Migrates to Trigger Immune Responses

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation.

27 Mar 2026

New Skin Atlas Reveals Cellular Diversity Across Body Sites

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body.

26 Mar 2026

Turning Plastic Bottles into Levodopa, a Key Parkinson’s Treatment

This study demonstrates the conversion of plastic bottles into levodopa using engineered bacteria, highlighting a novel approach to sustainable drug production.

25 Mar 2026

Unexpected SRC Localization Offers Promising Target for Cancer Therapies

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.

16 Mar 2026

Novel INSTALL Technology Achieves Non-Toxic Gene Integration in Multiple Cell Types

Genome editing-based therapies typically aim to treat disease by correcting underlying genetic mutations in patient's cells.

12 Mar 2026

Functional Mitochondria Key to Recovery of Dying Photoreceptor Cells

Photoreceptors are specialized cells in the eye that convert light energy into neural signals.

12 Mar 2026

Study Maps the Complete Genetic Blueprint for Loganin Biosynthesis

Plant-derived terpenoids play essential roles in medicine, agriculture, and human health, but their biosynthesis is often complex and tightly regulated.

5 Mar 2026

New Cell-Free Method Reveals Hidden Rules of Bacterial Gene Expression

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression.

5 Mar 2026

Bacteria-Powered Drug Discovery: A Greener Path to Curing "Undruggable" Cancers

Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilize, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.

4 Mar 2026

How Catalytic RNA Redefined Enzymes and the Origin of Life

There have been many important discoveries along the path to what we know today about RNA, or ribonucleic acid-a molecule found in every living cell that helps carry and interpret genetic instructions.

2 Mar 2026

Single-Cell Atlas Reveals Coordinated Aging Across Multiple Organs

As we age with each passing year, we become more susceptible to chronic diseases like cancer, heart disease, and dementia.

27 Feb 2026

Scientists Map Protein Production Across Individual Brain Cells

The brain's ability to do everything from forming memories to coordinating movement relies on its cells producing the right proteins at the right time.

19 Feb 2026

New Stem-Cell Derived Platform Advances Study of Neural Network Maturation

An EEG (electroencephalogram) is a painless test that uses small sensors placed on the scalp to measure the brain's electrical activity.

19 Feb 2026

Study Reveals New Structural Role for HIV Integrase

The tiny shell protecting the HIV virus resembles a slightly rounded ice cream cone, but there is nothing sweet about it.

19 Feb 2026

Protrusion-Derived EVs Boost Protein Delivery Efficiency

Extracellular vesicles (EVs) are tiny membrane-bound particles released by cells to transport proteins and other molecules to neighboring cells. Because of this natural delivery ability, EVs have attracted growing interest as potential vehicles for therapeutic protein and genome-editing enzyme delivery.

16 Feb 2026

Mapping the Binding Energy of Histamine Receptors

G-protein-coupled receptors (GPCRs) are one of the biggest groups of cell surface proteins in the human body, recognizing hormones, neurotransmitters, and drugs.

16 Feb 2026