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Obesity allows cancer cells to outcompete tumor-killing immune cells, study finds

Obesity has been linked to increased risk for over a dozen different types of cancer, as well as worse prognosis and survival.

From Harvard Medical School 10 Dec 2020

CTC dynamics related to overall survival in patients with metastatic breast cancer

Early circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer, according to a meta-analysis presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

10 Dec 2020

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

Researchers capture wandering molecular fragments in real time

The observation of a chemical reaction at the molecular level in real-time is a central theme in experimental chemical physics.

9 Dec 2020

Researchers identify key molecular processes used by coronaviruses to survive

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

Damage to brain cells causes a chain reaction that impacts 'bystander' neurons

Injury or disease that afflicts a relatively small number of brain cells causes a chain reaction that stops activity across a vast network of neural circuits, according to new research from Oregon Health & Science University.

9 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020

Researchers use novel technique to visualize unlabelled live cells

Scientists from the University of Illinois Urbana Champaign have designed a new method that uses a combination of artificial intelligence and label-free imaging to observe unlabeled live cells across an extended time.

8 Dec 2020

Researchers discover genetic factors underlying diabetic retinopathy

In a quest to find the genetic factors that are fundamental to diabetic retinopathy, scientists from the University of Illinois Chicago (UIC) have also discovered a new method that can be employed as a template to investigate other types of diseases.

8 Dec 2020

Specific cellular pathways in the fetal gut may reactivate Crohn’s Disease

Researchers have successfully monitored the initial stages of gut development in a human fetus, in explicit detail.

8 Dec 2020

Tumor DNA in DLBCL patient's stem cells or blood can predict risk of relapse after transplant

Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse.

8 Dec 2020

Researchers discover molecular mechanism of plant immune receptors

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the sequence of molecular events that activate an inactive plant immune receptor and thus mediate the death of the host cell.

8 Dec 2020

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments.

8 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Gene therapy and medication can provide certain beneficial effects of physical exercise

Jose Bianco Moreira from NTNU is now convinced that gene therapy can be used to achieve the positive health benefits of physical exercise.

7 Dec 2020

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

According to a new study, a novel T cell genetically engineered by scientists from The University of Arizona Health Sciences can target and attack pathogenic T cells that are responsible for causing Type 1 diabetes. These latest findings may result in new immunotherapy therapies.

7 Dec 2020

Study determines 3D structure of molecular machine involved in placement of key proteins

Within a single cell, more than a quarter of all proteins are found in the membrane, in which they carry out crucial functions.

7 Dec 2020

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.

7 Dec 2020

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma, according to findings from a multi-institutional phase I study being presented by Alfred L. Garfall, MD, an assistant professor of Medicine in the division of Hematology-Oncology in the Perelman School of Medicine at the University of Pennsylvania, at the annual American Society of Hematology & Exposition Meeting on Dec. 5 (abstract #180).

7 Dec 2020

Cell News and Research

Obesity allows cancer cells to outcompete tumor-killing immune cells, study finds

CTC dynamics related to overall survival in patients with metastatic breast cancer

Repair proteins can help healthy cells to avoid damage during cancer therapy

Researchers capture wandering molecular fragments in real time

Researchers identify key molecular processes used by coronaviruses to survive

Damage to brain cells causes a chain reaction that impacts 'bystander' neurons

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

Researchers use novel technique to visualize unlabelled live cells

Researchers discover genetic factors underlying diabetic retinopathy

Specific cellular pathways in the fetal gut may reactivate Crohn’s Disease

Tumor DNA in DLBCL patient's stem cells or blood can predict risk of relapse after transplant

Researchers discover molecular mechanism of plant immune receptors

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

Gene therapy and medication can provide certain beneficial effects of physical exercise

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

Study determines 3D structure of molecular machine involved in placement of key proteins

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

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