Cytokine is a substance that is made by cells of the immune system. Some cytokines can boost the immune response and others can suppress it. Cytokines can also be made in the laboratory by recombinant DNA technology and used in the treatment of various diseases, including cancer.
Excessive consumption of fructose -; a sweetener ubiquitous in the American diet -; can result in non-alcoholic fatty liver disease (NAFLD), which is comparably abundant in the United States.
Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide.
Shiv Pillai, MD, Ph.D., investigator in the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School (HMS), recently published a paper in Cell showing that that high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2, the virus that causes COVID-19.
The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.
People may go to great lengths to fight aging, but this process is a part of life.
Arthritis affects almost 2% of the world's population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease. A new molecule developed in the laboratory has been shown to have potential therapeutic effects.
Analyses of lung fluid cells from COVID-19 patients conducted on a supercomputer point to patterns that may explain the body's response to SARS-CoV-2.
High cholesterol kills. In fact, one in four Americans will die from the consequences of atherosclerosis, the buildup of plaques of fat and cholesterol in the arteries. Statins have helped reduce mortality, but millions are still at risk.
A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of both the normal and acetylated forms of TGFBIp correlated with the severity of disease symptoms in these patients.
The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.
Mount Sinai researchers have pinpointed a single gene biomarker, nitride oxide synthase 2 (NOS2) that can distinguish atopic dermatitis (AD) and psoriasis with 100 percent accuracy using adhesive tape strips, a non-invasive alternative to skin biopsy.
Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.
New research has demonstrated that kidneys can be revived prior to transplantation by delivering a cell therapy directly to the organ.
The incidence of esophageal adenocarcinoma has increased 8-fold over the past 50 years. This is one of the deadliest cancers, with a five-year survival rate of only 20 percent.
Targeted radionuclide therapy has been found to create a favorable tumor microenvironment in prostate cancer that improves the effectiveness of immunotherapies.
More often, the human body is viewed as a “machine” containing specialized components: immune cells protect against pathogens, organs contribute physiological functions, and soft tissue and bones give structure.
The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).
A common food additive, recently banned in France but allowed in the U.S. and many other countries, was found to significantly alter gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver, according to research led by a University of Massachusetts Amherst food scientist.
Yale researchers have discovered a "jamming signal" that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors.
Researchers have demonstrated that a dysfunctional placenta can play a formerly unknown role during the earliest phases of development in Cornelia de Lange.