DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Yale and uOttawa researchers partner to solve a puzzle rooted in the deepest past of evolution

For decades, scientists have been trying to unravel an enduring mystery of structural biology: Why do two otherwise identical protein forms found in everything from plants, amphibians and human beings hang onto a slight variation across the mighty span of evolution?

21 Mar 2022

Scientists discover new details on vital enzyme that allows for DNA sequencing

Researchers released a study in Sciences Advances that disclosed new facts about a critical enzyme that allows DNA sequencing.

16 Mar 2022

Research develops novel ways to recreate totipotency by cellular reprogramming

Adult cells in our bodies can only produce cells of the same type. A skin cell, for example, can only produce skin cells and not muscle cells. This restricts the therapeutic potential of mature cells.

8 Mar 2022

New proteomics method identifies proteins responsible for regulating R-loop levels in human cells

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

Study provides insight into replication and transcription machinery of ranaviruses

Nucleo-cytoplasmic large DNA viruses (NCLDVs) of the genus Ranavirus (family iridoviridae) have been isolated from aquatic species such as reptiles, amphibians, and bony fish. Poikilotherms are at risk from these promiscuous infections.

21 Jan 2022

Experts identify proteins that regulate dual processes

According to recent research, the protein UBR7 acts as a histone chaperone and controls histone re-deposition at certain sites at the time of DNA replication.

22 Dec 2021

Live-cell probes enable visualization of the elongation phase of transcription

A genetically encoded “live-cell” probe developed by scientists from Tokyo Tech pinpointed phosphorylated Ser2 in the enzyme RNA polymerase II.

7 Dec 2021

Scientists test the accuracy of enzymes that copy DNA under weightlessness

Researchers at Queen’s University boarded a modified Falcon 20 aircraft at Ottawa airport on May 22nd, 2019 as part of a scheduled “vomit comet” flight. In this mode of flight, the plane repeatedly climbs in a steep parabola to 8 km, alternating with a freefall descent.

2 Dec 2021

Experts analyze key protein complexes involved in DNA replication and repair

Cryogenic electron microscopy (cryo-EM) allows scientists to investigate the assembly of DNA replication machinery where DNA is damaged.

25 Nov 2021

Researchers develop artificial genomic DNA capable of replication and evolution

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

22 Nov 2021

De Novo Mutations may Play a Role in Male Infertility

In this interview, we speak to Dr. Miguel J. Xavier about his latest research into male infertility and how de novo mutations may play a part.

From Newcastle University 19 Nov 2021

Study sheds light on the regulation of epigenetic modifications during the development

The hereditary material, DNA, interacts with proteins present in the cell nuclei and forms a tightly packed complex with proteins called “chromatin”.

29 Oct 2021

Study pinpoints the mutational hotspots in DNA

Recent research at the University of Bath reveals that tangles in unwound DNA can develop mutational hotspots in the genomes of bacteria.

From University of Bath 21 Oct 2021

Research findings likely to help better define risk factors in cancer

Scientists took a further step in the exploration of genetic instability, as exhibited in cancer cells.

7 Oct 2021

Premature aging of the tracheobronchial stem cells could contribute to chronic lung disease

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.

22 Sep 2021

Researchers develop a method to engineer new functionalities into cells

Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have developed a method to engineer new functionalities into cells. The results were published today in the journal Cell in the article "Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation".

26 Aug 2021