Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New study uncovers potential driver of Parkinson’s disease

Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.

24 Feb 2022

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Semarion Ltd, a University of Cambridge spin-out company from the Cavendish Laboratory combining materials engineering and cell biology to tackle unmet drug screening needs, announced today that it has closed a £2.14 million GBP seed funding round.

22 Feb 2022

Automata raises US $50 million in series B financing to accelerate automation in life science

Automata – the automation company helping life sciences rapidly innovate, diagnose and discover at scale – today announces it has raised US$50 million in Series B funding.

From Automata 22 Feb 2022

3D structure of protein channel helps shed light on sensitive touch response of Venus fly traps

Scientists at Scripps Research have revealed the three-dimensional structure of Flycatcher1, an aptly named protein channel that may enable Venus fly trap plants to snap shut in response to prey.

18 Feb 2022

NTU Singapore scientists design new method to generate sulfur pharmacophores

A key technical challenge in creating new sulfur-based medicines has been overcome by scientists at Nanyang Technological University, Singapore, leading to the prospect of many new therapeutic 'weapons' in the fight against disease and illness.

15 Feb 2022

Researchers design a molecule that prevents the replication of coronaviruses

Researchers have created a molecule that suppresses coronavirus replication and has the potential to be developed into a COVID-19 treatment drug.

14 Feb 2022

Agricultural fungicides generate resistance to antifungal medications, study finds

For the first time, a new study has revealed that drugs, used to treat fungal illnesses in plants, are also generating resistance to antifungal medications used to treat people.

From University of Georgia 14 Feb 2022

A simple route for synthesizing fungal compound and its derivatives

The solutions to many of humanity's problems can be found within nature. For instance, who could have guessed that an antibiotic as powerful as penicillin would be found in a common mold, or that the drug aspirin would be derived from the bark of the willow tree?

From Tokyo University of Science 10 Feb 2022

Identification of a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

9 Feb 2022

San Antonio researchers report a new mechanistic target for leukemia drug development

Scientists at The University of Texas Health Science Center at San Antonio believe it may be possible to prevent DNA changes driven by two proteins highly active in leukemia and other cancers.

7 Feb 2022

Scientists discover families of proteins that could predict organ transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

28 Jan 2022

Leukemia-on-a-chip; The Future of Preventing Therapy Resistance?

We speak to Dr. Chao Ma, one of the speakers at SLAS 2022, about his groundbreaking 'leukemia-on-a-chip' technology and its future within therapy resistance.

From Society for Laboratory Automation and Screening (SLAS) 27 Jan 2022

Culturing marine sponge cells in 3D could scale-up production of biomass, bioactive metabolites

There are more than 9,000 species of marine sponges (Phylum Porifera) worldwide, which are a source of novel natural products.

25 Jan 2022

Producing New Antibiotics Through Gene Editing

In this interview, we speak to Professor Jason Micklefield about his latest research that may be able to produce new antibiotics through gene-editing technologies.

From The University of Manchester 24 Jan 2022

Evaporators assist academic drug discovery

BioChromato Inc reports how the renowned Chemistry Research Laboratories (CRL) at Oxford University (UK) are using several Smart Evaporator C1 units to support their drug discovery activities in therapeutic areas including oncology and regenerative medicine.

From BioChromato Inc. 19 Jan 2022

Experts develop CRISPR-Cas9-mediated inheritance control in male mice

The world’s first CRISPR-Cas9 genetic editing-based strategy to regulate inheritance in mammals was declared nearly three years ago.

From UC San Diego 13 Jan 2022

Experts develop AI-based binding site detection in nucleic acid macromolecules

Skoltech’s iMolecule group has created a solution that employs data on the structure of molecules to detect sites where possible drug candidates could interact.

13 Jan 2022

TetraScience announces 300% ARR growth and 2021 achievements; prepares for next phase of growth

TetraScience, the R&D Data Cloud Company, is pleased to share highlights from a record-breaking 2021 fiscal year, including 300% annual recurring revenue (ARR) growth, an $80M Series B funding round, and full operationalization of the Tetra Partner Network.

From TetraScience, Inc. 12 Jan 2022

Pyroptosis is not a one-way ticket, it can be halted and controlled

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis -; the process of cell death that is usually caused by infections and results in excess inflammation in the body -; and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

11 Jan 2022

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

NeoCura and PhoreMost today announced an oncology drug discovery research collaboration.

From PhoreMost 11 Jan 2022