Endonuclease News and Research

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Targeting Long-read RNA Sequencing with Low-Cost Technology

Researchers at the Children’s Hospital of Philadelphia (CHOP) have created a flexible and affordable approach for targeted sequencing of full-length RNA molecules, which might hasten the development of novel diagnostics and therapies.

16 Aug 2023

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Feng Zhang of the Broad Institute at MIT and Harvard and the McGovern Institute for Brain Research at MIT headed a team of researchers who discovered the first programmable RNA-guided mechanism in eukaryotes, which include fungi, plants, and animals.

29 Jun 2023

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.

19 Apr 2023

New insights into the distribution and regulation of meiotic DSB hotspots

A new method, DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling was developed recently.

3 Mar 2023

Study illuminates how lung cells protect themselves against RNA viral infection

A new University of California, Irvine-led study uncovers how a protein, APOBEC3B, could protect cells against many different types of RNA viruses like respiratory syncytial virus (RSV), SARS-CoV2, influenza virus, poliovirus and measles, helping to prevent disease.

23 Feb 2023

Potential to rectify various disease-causing mutations enhanced by CRISPR-based enzymes

Designing genome editing strategies for each patient’s mutation would be impractical and expensive because many genetic diseases are induced by diverse mutations spread across an entire gene.

18 Jan 2023

Researchers determine a novel antiviral technique to combat bacteria

Bacteria use a wide range of defense strategies to combat viral infection, and some of these systems have resulted in game-changing technologies like CRISPR-based gene editing.

From Massachusetts Institute of Technology (MIT) 15 Aug 2022

Newly discovered RNA-guided endonucleases can be harnessed for genome editing in cells

Researchers seeking to understand the origins of CRISPR-Cas9 systems have uncovered a class of transposon-encoded RNA-guided nucleases, which they dubbed "OMEGA," that could be harnessed for genome editing in human cells.

14 Sep 2021

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

CRISPR-Cas9 system could help perform very effective target gene silencing

CRISPR-Cas9's extraordinary ability to modify specific areas of DNA has made it a favorite among gene-editing tools for researchers.

6 Jul 2021

Study reveals mechanisms behind the activation of MRN complex

Researchers from the Tokyo Institute of Technology have revealed mechanisms behind the stimulation of the MRN complex—the DNA scissors of the cells.

11 Mar 2021

A novel approach to identify cancer targets using 'synthetic lethality'

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of "synthetic lethality," exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

28 Jul 2020