Lupus News and Research

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Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
MicroRNA’s influence on lupus disease inflammation

MicroRNA’s influence on lupus disease inflammation

Detecting the extent of natural selection over time

Detecting the extent of natural selection over time

Improving potential of cellular therapies with CAR T therapy

Improving potential of cellular therapies with CAR T therapy

Genetic predisposition for SLE protective against severe COVID-19 infection

Genetic predisposition for SLE protective against severe COVID-19 infection

Using in vivo self-assembled siRNA as part of combination therapy for ulcerative colitis

Using in vivo self-assembled siRNA as part of combination therapy for ulcerative colitis

Researchers identify the molecular route that leads to autoimmune disease inflammation

Researchers identify the molecular route that leads to autoimmune disease inflammation

Study reveals genetic architecture of COVID-19 risk factors and disease complications

Study reveals genetic architecture of COVID-19 risk factors and disease complications

Genetic mutation that corresponds to small body size in dogs existed in ancient wolves

Genetic mutation that corresponds to small body size in dogs existed in ancient wolves

CRISPR screening identifies metabolic enzyme as new target for anti-inflammatory therapeutics

CRISPR screening identifies metabolic enzyme as new target for anti-inflammatory therapeutics

Study reveals how fine-tuning the immune system can improve vaccines, reduce disease severity

Study reveals how fine-tuning the immune system can improve vaccines, reduce disease severity

Nanobody mapping using NMR proves a promising alternative for therapeutic use

Nanobody mapping using NMR proves a promising alternative for therapeutic use

New kind of biomolecule could play a vital role in the biology of all living things

New kind of biomolecule could play a vital role in the biology of all living things

New genetic database maps how immune disorders evolve

New genetic database maps how immune disorders evolve

Key molecule determines the pathogenesis of lupus

Key molecule determines the pathogenesis of lupus

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Hyperactive RANK protein could trigger autoimmune diseases

Hyperactive RANK protein could trigger autoimmune diseases

Study may lead to new treatments for autoimmune diseases

Study may lead to new treatments for autoimmune diseases

Main bioactive compound of ginger root counteracts autoimmune diseases in mice

Main bioactive compound of ginger root counteracts autoimmune diseases in mice

Study reveals metabolic signaling pathways that influence key immune cells

Study reveals metabolic signaling pathways that influence key immune cells

Study identifies genes and molecular pathways most sensitive to chemical exposures

Study identifies genes and molecular pathways most sensitive to chemical exposures