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QRICH1 Protein Found to Control T Cell Activation in Cancer and Autoimmune Diseases

In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases.

9 Apr 2025

Researchers Develop Cellulose-Based 3D Scaffolds That Mimic Natural Tissue Architecture

This research outlines a protocol for nano-fibrillated cellulose scaffolds, crucial for tissue engineering, emphasizing mechanical stability and cell viability.

9 Apr 2025

New Research Reveals Mitochondrial Guardians Linked to Parkinson’s and ALS

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.

8 Apr 2025

Scientists Unveil Dynamic Structure of Vision-Linked Protein RBP3

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought.

8 Apr 2025

Study Reveals How Stiffened Osteocytes Contribute to Bone Loss in Aging

It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

7 Apr 2025

Scientists Discover Epigenetic Marks in Pancreatic Cancer Transition

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

7 Apr 2025

DNA Aptamers Offer Precision Attack Against Leukemia Stem Cells

Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report.

4 Apr 2025

USC Engineers Develop EchoBack CAR T-Cells for Cancer Treatment

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

3 Apr 2025

Scientists Build Live African Swine Fever Virus From Synthetic DNA Using CRISPR

Utilizing CRISPR-Cas9, scientists reconstitute live African swine fever virus from synthetic genomes, accelerating vaccine development for this deadly virus.

2 Apr 2025

AI Brings Brain Metabolism to Life in 3D with MetaVision3D

The MetaVision3D tool transforms 2D tissue sections into 3D brain metabolome models, offering critical insights into metabolism and neurological diseases.

31 Mar 2025

Breakthrough Gene Therapy Shows Promise for Treating Hereditary Hearing Loss

Congenital hearing loss refers to impaired auditory function that occurs due to genetic causes. GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss.

28 Mar 2025

Study Reveals How H3K36 Methylation Controls Intestinal Cell Plasticity and Regeneration

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

26 Mar 2025

Hidden Causal Interaction Network Found in Cervical Cancer Cells

A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network.

26 Mar 2025

Immune System Peacekeepers Key to Preventing Autoimmunity During Infection

During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and viruses from self-antigens that are expressed by cells of the body.

24 Mar 2025

Your Brain Maps Social Interactions Like a GPS

A study reveals how the brain uses 'basis functions' to simplify social decision-making, impacting biases and teamwork dynamics in group settings.

24 Mar 2025

Can Tissue Engineering and Regenerative Medicine Reverse Spinal Cord Injuries?

Advances in tissue engineering offer hope for spinal cord injury repair, utilizing biomaterials, stem cells, and bioactive molecules to promote regeneration.

20 Mar 2025

Rethinking Cancer: Moving Beyond Genetic Mutations to a Holistic View

It's time for researchers to reconsider the current paradigm of cancer as a genetic disease, argued Sui Huang from the Institute for Systems Biology, USA, and colleagues in a new essay published March 18th in the open-access journal PLOS Biology.

19 Mar 2025

Understanding How Tumor-Derived Extracellular Vesicles Enter Target Cells

Most cells in the body send out little messengers called extracellular vesicles that carry proteins, lipids, and other bioactive molecules to other cells, playing an important role in intercellular communication.

17 Mar 2025

New Discovery in RNA Splicing Could Transform Treatment of Aggressive Cancers

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film.

17 Mar 2025

Stanford Researchers Find a Molecule That Rivals Ozempic in Weight Loss

BRP emerges as a promising peptide for weight loss, activating appetite control pathways without triggering nausea, paving the way for safer obesity therapies.

17 Mar 2025