Molecular & Structural Biology

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Missing Microexons Disrupt Synapse-Related Proteins in Pediatric Glioma

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

19 Aug 2025

Atomic-Level Models Reveal New Class Of Protein Misfolding

New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding.

11 Aug 2025

ISGlobal Develops HTGAnalyzer to Simplify Transcriptomic Data Analysis

The Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, has launched HTGAnalyzer, a new, easy-to-use, fast and reproducible bioinformatics tool for advanced transcriptomic data analysis.

11 Aug 2025

Researchers Uncover How Macrophages Respond to Infection Stress

Fighting infections requires speed and accuracy. A team of researchers from CeMM and MedUni Vienna, led by Christoph Bock and Matthias Farlik, explored how macrophages—the body’s initial responders—handle this stress.

11 Aug 2025

Unique Chemical Fingerprints Offer New Weapon Against Counterfeit Medicines

Medicines have a unique chemical fingerprint, according to a new study from the University of Copenhagen. Researchers say this knowledge can be used to trace counterfeit or stolen medicine.

8 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

Ribosome Levels Drop During Early Brain Development

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making proteins.

6 Aug 2025

Simple Peptides Mimic Natural Protein Protection to Revolutionize Biomolecule Stability

A new study from researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) reveals that extremely simple peptides can mimic a biological process that protects sensitive proteins from environmental stress.

6 Aug 2025

CD276 Antibody Strategy Offers Hope For Immune-Resistant Lung Tumors

The study highlights 8H8_SDIE's role in activating NK cells against NSCLC, offering a new strategy for patients resistant to conventional immunotherapies.

6 Aug 2025

Small Protein LptM Plays Key Role in Assembling Protective Outer Membrane in Bacteria

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria.

5 Aug 2025

Scientists Uncover New Activation Mechanism of the Human Sweet Taste Receptor

Sweet taste receptors are proteins in taste buds that detect sugar and other sweeteners, but the mechanism underlying how they elicit a sweet response has been unclear.

5 Aug 2025

Researchers Identify Key Gene for Restoring Fertility in Hybrid Peppers

Cytoplasmic male sterility (CMS) systems have revolutionized hybrid seed production by eliminating the need for manual pollen removal.

30 Jul 2025

Bacterial Battle Strategies Involve Durable Amyloid Armor

Amyloids are perhaps best known as a key driver of Alzheimer's disease.

30 Jul 2025

PD-1 Guides T Cells to Become Long-Term Immune Defenders in the Skin

Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.

30 Jul 2025

Proteins as a Natural Weapon Against Predatory Bacteria

Amyloids are perhaps best recognized as a major cause of Alzheimer’s disease.

30 Jul 2025

AI-Designed Proteins Offer New Hope for Personalized Cancer Immunotherapy

Precision cancer treatment on a larger scale is moving closer after researchers have developed an AI platform that can tailor protein components and arm the patient's immune cells to fight cancer.

29 Jul 2025

Stability in Proteins Is More Like Lego Than Jenga

Proteins are life's molecular workhorses, doing everything from turning sunlight into food to fighting viruses.

29 Jul 2025

dpMIG-seq Enables Efficient Genetic Analysis of Tetraploid Blueberry

Polyploid crops, such as blueberries, often exhibit complex inheritance patterns that complicate genetic analysis and hinder breeding efforts.

29 Jul 2025

Rewriting rRNA Alters the Architecture of the Nucleolus

Ribosomes carry out the cell's most essential function-translating genetic information into proteins.

28 Jul 2025

How DNA Packaging Shapes p53 Activity

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers-about a millionth of a milliliter.

28 Jul 2025