Molecular & Structural Biology

RSS

How the Microbiome Shapes Cancer Immunity and Therapy Response

This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.

29 Apr 2026

New Pistoia Alliance Poll Finds Regulatory Teams Benefit Most from AI, But Just 1 % See Value in the Wet Lab

The Pistoia Alliance, a global, not-for-profit that advocates for greater collaboration in life sciences R&D, has released new poll data from its annual European conference, revealing that while AI use is becoming widespread across life sciences organizations, its measurable impact on drug R&D remains limited.

From The Pistoia Alliance 29 Apr 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

Intermediate PRRX1 Levels Drive Breast Cancer Metastasis Risk

The study identifies PRRX1 as a critical factor in breast cancer metastasis, highlighting its potential as a biomarker for predicting aggressive disease.

29 Apr 2026

Drug Development: Development of Dextran Nanoparticles for Stabilizing Delicate Proteins

Nanoscale Research Letters, an open access journal published under Springer Open, presented a study entitled "Development of Dextran Nanoparticles for Stabilizing Delicate Proteins." In this study, a Brookhaven NanoBrook 90Plus Particle Size Analyzer was used to help develop a novel approach to stabilize and encapsulate proteins into dextran nanoparticles.

From Brookhaven Instruments 29 Apr 2026

High Resolution Images Reveal DNA Repair Process in Key Protein

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

28 Apr 2026

Protein Adgrl2 Regulates Brain Synapses and Blood Vessel Integrity

The communication network in the developing brain builds when neurons partner up to form contact points called synapses, allowing signals to pass form one cell to another.

28 Apr 2026

Dense Early Brain Networks Become Structured Through Developmental Pruning

One important area of the brain involved in memory formation and spatial orientation is the hippocampus. It helps people remember and expand upon their experiences by converting short-term memories into long-term ones.

27 Apr 2026

Plant Peroxisome Study Offers New Insights Into Conserved Cellular Functions

For most of their lives, plants get their energy from photosynthesis. But during the seed to seedling stage when they can't absorb light just yet, they rely on other sources, like fatty acids.

25 Apr 2026

Stress Response in Polyploid Cells Fuels Cancer Progression

One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment.

24 Apr 2026

Structural Insight Into Vibrio Bacteria Opens Way for New Treatment Strategies

Scientists have mapped in unprecedented detail the structure of Vibrio bacteria, which can cause life-threatening infections linked to antibiotic resistance.

24 Apr 2026

New Study Uncovers Previously Undetected Form of DNA Damage

In everyday life, our genetic material is constantly under attack from many factors. Environmental influences such as light, along with internal processes like inflammation, can generate oxidative stress that damages DNA and its downstream partner, RNA, which can lead to faster aging and diseases such as cancer.

24 Apr 2026

Uncovering a Second Pathway for On-Demand Glycogen Regulation

Researchers at WEHI have uncovered a never-before-seen mechanism that human bodies utilize to control sugar. These discoveries redefine basic biological principles and pave the way for new scientific discoveries.

24 Apr 2026

New Methods Increase Understanding of How Bacteria Manage DNA

New analytical methods developed at Baylor College of Medicine and collaborating institutions have increased our understanding of how bacteria manage DNA.

23 Apr 2026

Researchers Find COVID-19 Shifting Toward an Endemic Phase

The World Health Organization declared the global health emergency related to the COVID-19 pandemic over in 2023, as most people had developed immune protection against the virus through vaccination and/or prior infection.

23 Apr 2026

New Molecular Imaging Technology Illuminates Proteins Inside Living Cells

Fluorescent probes have transformed modern biology by allowing researchers to tag and visualize individual molecules in living cells, tissues, and animals.

22 Apr 2026

Molecular Keyhole Discovery Unlocks New Target for Pain Therapies

Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular 'keyhole', in the TRPM3 ion channel, a crucial sensor in pain signaling.

22 Apr 2026

Phages Communicate Across Species to Control Infection Decisions

Recent research reveals that bacteriophages can communicate across species, influencing infection dynamics and microbial ecosystems through arbitrium peptides.

22 Apr 2026

Regulatory Genetic Elements Coordinate Temporal Activity of Key Developmental Gene

In a new study published in Genes & Development, research led by Dr Lila Allou at the MRC Laboratory of Medical Sciences (LMS) in London and Professor Stefan Mundlos at the Max Planck Institute for Molecular Genetics and Charité in Berlin demonstrates how different regulatory genetic elements coordinate the temporal activity of a key developmental gene.

20 Apr 2026

Gene Editing Reprograms Immune System to Produce Therapeutic Proteins

An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins-including certain kinds of highly potent antibodies the are naturally difficult to produce-by reprogramming the immune system itself.

20 Apr 2026