Molecular & Structural Biology

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Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

26 Sep 2026

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

A new study from The Wistar Institute has found a link between the nervous system and the rapid development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

26 Sep 2026

Individual Neurons Display Trial-to-Trial Firing Rate Variability Under Identical Visual Stimulation

Our brains internally represent the outside world through the coordinated activity of billions of neurons.

25 Sep 2026

Cryo-ET Reveals Native Membrane Architecture of Synchronous RyR1 Calcium Channels

Using cryo-electron microscopy, researchers at the Max Delbrück Center have revealed how muscle cell calcium channels open synchronously. The findings, published in "Nature Communications," may explain a mechanism behind serious muscle diseases.

25 Sep 2026

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

Gut microbiota influences multiple aspects of host physiology, including metabolic and immune functions. Many metabolites produced by gut bacteria can cross the intestinal epithelium (which the bacteria may not be able to cross) and enter host tissues, providing a pathway through which microbial activity can influence host physiology.

25 Sep 2026

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

25 Sep 2026

Multi-Receptor Blocking Achieves Superior Antifibrotic Response Over Single-Receptor Inhibition

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart. Blocking the receptors together produced a much stronger antifibrotic effect than blocking them one at a time.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Ultra-High-Resolution 3D Microscopy Captures Distinct Presynaptic Protein Organization States

A new study led by researchers at the University of Wisconsin School of Medicine and Public Health examines how different versions of the same protein can alter neuronal communication.

25 Sep 2026

Garvan Researchers Uncover Genetic Causes of Inherited Muscle Disease

A world-first test developed by researchers at the Garvan Institute of Medical Research has identified the genetic cause of inherited muscle disease in people who remained without answers after years, sometimes decades, of standard testing.

25 Sep 2026

Scientists Discover Why High Levels of the Amino Acid Cysteine Are Toxic to Cells

Cysteine is one of the main building blocks that cells use to make proteins. But this amino acid is a double-edged sword–too much cysteine is toxic to the cell.

24 Sep 2026

Study Uncovers Two-Protein Repair Mechanism Preserving Circular ecDNA Stability

Researchers at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues have discovered that a type of rogue DNA found in aggressive cancers has a hidden structural weakness - and that blocking a single repair protein can cause it to fall apart, suggesting a new therapeutic opportunity.

24 Sep 2026

Trans-spliceosome Architecture Maps Evolutionary Divergence in Eukaryotic RNA Processing

A study conducted between the University of Liège and Rockefeller University reveals, with near-atomic precision, the three-dimensional structure and function of a gigantic molecular machine essential to the survival of trypanosomatid parasites, which cause serious diseases in humans, animals and plants.

24 Sep 2026

Latent HIV Viral Proteins Drive Persistent Low-Grade Brain Inflammation During ART

Antiretroviral drugs let people with HIV live full-length lives, but cognitive problems often persist. Some studies have found cognitive impairment in as many as half of people receiving antiretroviral therapy, although estimates vary and many cases do not interfere with daily activities.

24 Sep 2026

Bio-Techne Opens New Customer Experience Center in Düsseldorf to Accelerate Scientific Discovery and Customer Collaboration

Bio-Techne Corporation, a global provider of life science tools, reagents and diagnostic products, today announced the opening of its new Customer Experience Center in Düsseldorf, Germany, a flagship facility designed to bring European customers closer to Bio-Techne's latest innovations and scientific expertise.

From Bio-Techne 22 Sep 2026

Tumor Suppressor Pathways Remain Intact but Hyperactive During Progressive Tissue Aging

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

22 Sep 2026

Study Maps Precise Anatomical Circuits Within the Brainstem Locus Coeruleus

Deep in the brainstem sits a small but important cluster of neurons known as the locus coeruleus (LC), Latin for "blue place."

21 Sep 2026

Obesity May Remove a Natural Defense Against Breast Cancer

A research team at Huntsman Cancer Institute at the University of Utah (the U) has found that obesity prevents a biological process that kills cancerous cells, revealing a possible reason why obesity is a risk factor for breast cancer.

18 Sep 2026

Researchers Reveal How p53 Tumor-Suppressor Protein Hide From T Cells

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see.

18 Sep 2026

Uncovering the Molecular Networks Governing Signal Crosstalk Inside Complex Plant Cells

Cells rely on complex signaling networks in which different molecular pathways communicate with one another. Small GTPases act as molecular switches in these networks, controlling diverse cellular processes such as intracellular transport and cell morphogenesis.

18 Sep 2026

Molecular & Structural Biology

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

Individual Neurons Display Trial-to-Trial Firing Rate Variability Under Identical Visual Stimulation

Cryo-ET Reveals Native Membrane Architecture of Synchronous RyR1 Calcium Channels

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Multi-Receptor Blocking Achieves Superior Antifibrotic Response Over Single-Receptor Inhibition

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Ultra-High-Resolution 3D Microscopy Captures Distinct Presynaptic Protein Organization States

Garvan Researchers Uncover Genetic Causes of Inherited Muscle Disease

Scientists Discover Why High Levels of the Amino Acid Cysteine Are Toxic to Cells

Study Uncovers Two-Protein Repair Mechanism Preserving Circular ecDNA Stability

Trans-spliceosome Architecture Maps Evolutionary Divergence in Eukaryotic RNA Processing

Latent HIV Viral Proteins Drive Persistent Low-Grade Brain Inflammation During ART

Bio-Techne Opens New Customer Experience Center in Düsseldorf to Accelerate Scientific Discovery and Customer Collaboration

Tumor Suppressor Pathways Remain Intact but Hyperactive During Progressive Tissue Aging

Study Maps Precise Anatomical Circuits Within the Brainstem Locus Coeruleus

Obesity May Remove a Natural Defense Against Breast Cancer

Researchers Reveal How p53 Tumor-Suppressor Protein Hide From T Cells

Uncovering the Molecular Networks Governing Signal Crosstalk Inside Complex Plant Cells

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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