Molecular & Structural Biology

RSS

Novel Two-Dimensional Mapping Combines Generation Probability with Somatic Hypermutation

A research team led by Associate Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, and Professor Hironobu Minami of the Division of Medical Oncology/Hematology at Kobe University Hospital, together with Associate Professor Goh Ohji of the Division of Infectious Disease Therapeutics and Takaji Matsutani of Anymics Inc., has developed the pGen-SHM plot.

5 Oct 2026

ESTEVE CDMO Expands U.S. Capacity with Additional $17.5 Million Investment in Morton Grove

ESTEVE CDMO, a global pure-play CDMO specializing in the development and manufacture of small-molecule APIs and pharmaceutical intermediates, has approved an additional $17.5 million capacity expansion and containment capabilities at its Morton Grove, Illinois facility, bringing total announced investment at the site to $33 million.

From ESTEVE CDMO 5 Oct 2026

Harvard Cryo-EM Center Visualizes Viral Genome Ejection Into Human Cells

Viruses come in two major flavors — not chocolate and vanilla, quips Harvard Medical School structural biologist Stephen Harrison, but those enveloped in membranes, such as herpesvirus, influenza virus, HIV, and SARS-CoV-2, and those that are not, such as poliovirus, HPV, rotavirus, and adenovirus.

5 Oct 2026

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Blocking USP15 in ovarian cancer cells disrupts growth and enhances chemotherapy sensitivity, revealing a potential target for overcoming treatment resistance.

1 Oct 2026

Electron Microscopy Imaging Confirms Piezo1-Dependent Axonal Sheath Structural Remodeling

Researchers at Upstate Medical University have identified a key mechanism that helps determine the length of myelin, the protective coating that surrounds many nerve fibers and allows signals to travel efficiently through the nervous system.

1 Oct 2026

Decoding the Mechanisms Behind Long-Term Epigenetic Gene Regulation Shifts

The transmission of biological traits from one generation to the next is generally attributed to DNA. But could some changes be passed on without altering the DNA sequence?

30 Sep 2026

Targeted Y Chromosome Deletions Disrupt Key Cellular Immune Response Pathways

A new study found that cancer cells selectively chip away gene-rich sections of the Y chromosome, triggering ripples that regulate tumor growth.

29 Sep 2026

Study Establishes Immune Cell Trafficking as Viable Alzheimer's Target

There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.

29 Sep 2026

Single-Cell Sequencing Confirms Epigenetic Remodeling Across Diverse Cardiac Cell Types

The adult human heart is a reliable and resilient engine fueling our everyday lives while also being responsive enough to supercharge a Usain Bolt sprint or sustain a three-week bike race in the French Alps and Pyrenees.

29 Sep 2026

Post-Translational Modification Crosstalk Regulates Oncogenic Protein Stability and Activity

A review published in Genes & Diseases highlights the complex interplay between protein arginine methylation and ubiquitination, two forms of protein modification that can profoundly influence cancer development, progression and treatment response. The article brings together current understanding of how these interconnected molecular processes regulate proteins involved in cancer and identifies opportunities for future therapeutic approaches.

28 Sep 2026

AI Decodes Spatial DNA Packaging Patterns Invisible to Researchers

Aging progressively affects the functioning of our body and, among other things, deteriorates the ability of the hematopoietic system- the set of organs and tissues responsible for producing blood cells- to maintain adequate blood cell production.

28 Sep 2026

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

26 Sep 2026

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

A new study from The Wistar Institute has found a link between the nervous system and the rapid development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

26 Sep 2026

Individual Neurons Display Trial-to-Trial Firing Rate Variability Under Identical Visual Stimulation

Our brains internally represent the outside world through the coordinated activity of billions of neurons.

25 Sep 2026

Cryo-ET Reveals Native Membrane Architecture of Synchronous RyR1 Calcium Channels

Using cryo-electron microscopy, researchers at the Max Delbrück Center have revealed how muscle cell calcium channels open synchronously. The findings, published in "Nature Communications," may explain a mechanism behind serious muscle diseases.

25 Sep 2026

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

Gut microbiota influences multiple aspects of host physiology, including metabolic and immune functions. Many metabolites produced by gut bacteria can cross the intestinal epithelium (which the bacteria may not be able to cross) and enter host tissues, providing a pathway through which microbial activity can influence host physiology.

25 Sep 2026

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

25 Sep 2026

Multi-Receptor Blocking Achieves Superior Antifibrotic Response Over Single-Receptor Inhibition

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart. Blocking the receptors together produced a much stronger antifibrotic effect than blocking them one at a time.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Ultra-High-Resolution 3D Microscopy Captures Distinct Presynaptic Protein Organization States

A new study led by researchers at the University of Wisconsin School of Medicine and Public Health examines how different versions of the same protein can alter neuronal communication.

25 Sep 2026

Molecular & Structural Biology

Novel Two-Dimensional Mapping Combines Generation Probability with Somatic Hypermutation

ESTEVE CDMO Expands U.S. Capacity with Additional $17.5 Million Investment in Morton Grove

Harvard Cryo-EM Center Visualizes Viral Genome Ejection Into Human Cells

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Electron Microscopy Imaging Confirms Piezo1-Dependent Axonal Sheath Structural Remodeling

Decoding the Mechanisms Behind Long-Term Epigenetic Gene Regulation Shifts

Targeted Y Chromosome Deletions Disrupt Key Cellular Immune Response Pathways

Study Establishes Immune Cell Trafficking as Viable Alzheimer's Target

Single-Cell Sequencing Confirms Epigenetic Remodeling Across Diverse Cardiac Cell Types

Post-Translational Modification Crosstalk Regulates Oncogenic Protein Stability and Activity

AI Decodes Spatial DNA Packaging Patterns Invisible to Researchers

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

Individual Neurons Display Trial-to-Trial Firing Rate Variability Under Identical Visual Stimulation

Cryo-ET Reveals Native Membrane Architecture of Synchronous RyR1 Calcium Channels

Engineered E. coli Strains Validate Putrescine Uptake and Systemic Host Conversion

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Multi-Receptor Blocking Achieves Superior Antifibrotic Response Over Single-Receptor Inhibition

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Ultra-High-Resolution 3D Microscopy Captures Distinct Presynaptic Protein Organization States

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

RecentIndustryFocuses

Editorial Focus eBook - Biopharmaceuticals (2nd edition)

Improving Cell Culture Efficiency with Image-Guided Automation

Improving Scalability in Organoid Research

Cosmetic Formulation and Manufacturing

Latest in Genomics