DNA Damage News and Research

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DNA repair tool is tailored to deal with specific type of complex break, study shows

Our cells are constantly dividing, and as they do, the DNA molecule - our genetic code - sometimes gets broken. DNA has twin strands, and a break in both is considered especially dangerous.

7 Jul 2020

MRI Scan Used For Heart Disease Could Also Pick Out Aggressive Cancers

An MRI scan used for heart disease could help assess whether children's cancers are especially aggressive and spot early signs that treatments are working.

29 Jun 2020

Lesion segregation can drive complex patterns of mutations in tumor genomes

Researchers from the German Cancer Research Center, Cambridge, and Edinburgh have been analyzing the evolution of tumors after chemical damage.

26 Jun 2020

Study shows how chemicals cause complex cell mutations

Fresh insights into why some harmful substances are so efficient at causing cancer could aid the quest for better treatments.

25 Jun 2020

Novel precision medicine targets cancer's DNA defenses

A new precision medicine targeting cancer's ability to repair its DNA has shown promising results in the first clinical trial of the drug class.

23 Jun 2020

Study sheds light on DNA sculpting properties of enigmatic protein

Sometimes, when something is broken, the first step to fixing it is to break it even more. In a recent example, scientists seeking to understand the mechanism of a DNA-repairing enzyme have discovered that the molecule performs its functions by first marking and then further breaking damaged DNA.

22 Jun 2020

New system of gene editing allows for targeted, super-fast DNA repair

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

18 Jun 2020

Dysfunctional placenta can contribute to Cornelia de Lange syndrome

Researchers have demonstrated that a dysfunctional placenta can play a formerly unknown role during the earliest phases of development in Cornelia de Lange.

17 Jun 2020

TU Dresden study uncovers enzyme essential for intestinal epithelial differentiation

The intestinal epithelium is the inner layer of the intestinal wall, which separates host tissue from the intestinal microbiota.

9 Jun 2020

DNA damage and repair jointly shape mutational signatures

A collaborative project between the Center for Genome Integrity, within the Institute for Basic Science, and the Dundee School of Life Sciences, the EMBL's European Bioinformatics Institute, and the Wellcome Sanger Institute have screened almost 163,000 DNA mutations in 2,700 C. elegans roundworms to shed light on DNA damage.

9 Jun 2020

Genome rewiring could help explain evolution of multi-cellular organisms

InsideOutBio expert Dr Alan Herbert has explained a pioneering research in a paper recently published online by the Royal Society Open Science journal.

9 Jun 2020

C19ORF57 gene could advance reproductive medicine

The gene C19ORF57 has been identified to play a major role in meiosis by the Institute of Molecular Embryology and Genetics at Kumamoto University.

5 Jun 2020

Study demonstrates the role of p53 gene in cell cycle regulation and apoptosis

The p53 gene is crucial in cell biology and thus cell replacement therapy. The function of this gene is to control the cell cycle and stop tumor formation.

2 Jun 2020

Mechanically rejuvenated fibroblasts show promise in stem cell engineering

Fibroblasts synthesize the collagen, creating the structural framework for animal tissues, and play a significant role in the process of wound healing.

27 May 2020

New sequencing method helps map the spatial arrangement of DNA

A sequencing technique helps to map the spatial arrangement of DNA in the cell nucleus, revealing which regions of the genome are at greater risk of mutation.

27 May 2020

Aging neurons build up DNA damage, study finds

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

Stem cell research may improve regenerative medicine

A new study has provided new insight into the mechanisms that cause mutations in pluripotent stem cells, offering potential ways for preventing mutations.

18 May 2020

Study reveals proteins that sustain cancer cells

Scientists from the University of Copenhagen have identified two major functions of the protein known as RTEL1 during cell division, in a recently performed study.

14 May 2020

Infrared spectroscopy reveals DNA molecular processes in real time

DNA strand breaks can play a role in the aging process. Now, with infrared spectroscopy, scientists have visualized the processes that take place at breaks.

4 May 2020