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Genome-Scale Analysis Reveals Cholera's Evolution

The genetic components that make the cholera-causing bacterium so lethal have been identified by experts using a state-of-the-art computational method, and this information may be crucial to averting the terrible illness.

24 Sep 2024

New Gene Editing Tool Shows Promise for Treating Diseases

Bacterial and archaeal CRISPR-Cas systems, comprising protein and RNA components, were initially developed as a natural defense mechanism against invading viruses.

24 Sep 2024

A New Understanding of the Effects of Fever on Immune Cells

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

23 Sep 2024

Unraveling the Genetic Mechanisms Underlying Fruit Size and Sugar Content in Wax Apple

A recent study has successfully decoded the autotetraploid genome of the wax apple, uncovering its genetic evolution and key factors driving fruit diversity. The research highlights the fruit's rich antioxidant profile, with promising implications for human health and breeding strategies aimed at enhancing nutritional value.

23 Sep 2024

Novel Tool Helps Identify Snake Venom Genes Across Species

Only about ten percent of the world's roughly 4,000 snake species have venom strong enough to seriously hurt a human, but that's enough for snake bites to be an important public health concern.

20 Sep 2024

Comprehensive multi-omics approach reveals detailed insights into diabetes mechanisms

In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.

20 Sep 2024

Ancient Genomes Reveal Long-Term Genetic Stability in Southernmost Africa

Around 13 individuals, who died between 1,300 and 10,000 years ago, had their genomes reconstructed by a team of researchers from the University of Cape Town (South Africa) and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, using analysis of human remains found in the southern African rock shelter.

20 Sep 2024

Genetic Blueprint Reveals Germination Barriers in the Endangered Jacktree

A pivotal study unveils the genetic blueprint of the endangered Jacktree, shedding light on the molecular factors hindering its germination.

19 Sep 2024

The Role of Ancient Viral Sequences in Gene Regulation

For any organism to survive and thrive, its cells must tightly control which genes are activated when, and where.

19 Sep 2024

Research Shows a Causal Role of Histone Modifications in Gene Regulation

For any organism to survive and thrive, its cells must strictly control which genes are active when and where.

19 Sep 2024

Epigenetic Switch Found to Activate Genes in Embryos

Researchers led by the Institute of Molecular Biology have found that 5-formylcytosine (5fC), a DNA alteration, acts as an activating epigenetic switch to activate genes during the early stages of embryonic development.

19 Sep 2024

ERGA Pilot Project Unites Scientists to Deliver High-Quality Genomes

The European Reference Genome Atlas (ERGA) has announced the outcome of its pilot project in a new article.

18 Sep 2024

Study Expands Potential of Retrons for DNA Editing

Within bacterial cells, specialized immune systems known as retrons fend off viral attacks. But that's not all they can do.

18 Sep 2024

New Insights into How Mutant p53 Promotes Tumor Growth

Research from the Federal University of Rio de Janeiro (UFRJ) and the National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB) in Brazil has uncovered a critical mechanism by which mutations in the p53 protein-;a key tumor suppressor known as the "guardian of the genome"-;turn other proteins into cancer-promoting agents

17 Sep 2024