Pathophysiology News and Research

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Low protein synthesis in humans causes rare intestinal disease

According to a recent study, which will be published on November 1st, 2022, by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues, a decrease in protein synthesis in growing gut cells contributes to a rare genetic condition, and an affordable nutritional supplement could help reverse that decrease.

3 Nov 2022

Rare and protective loss-of-function mutations offer possible NAFLD drug targets

A significant genome-wide association study on the nonalcoholic fatty liver disease (NAFLD) has just been published in Nature Genetics by researchers from Amgen subsidiary deCODE Genetics.

26 Oct 2022

Scientists decipher a direct dialog between the gut microbiota and the brain

Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions.

From Institut Pasteur 18 Apr 2022

HIF-1alpha inhibitor preserves the activity of insulin-producing beta cells in diabetic mice

High blood glucose is responsible for several complications in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden have identified a new antidiabetic substance that preserves the activity of insulin-producing beta cells and prevents high blood glucose in mice.

31 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

8 Mar 2022

Largest genome study identifies new genetic risk factors for migraine

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

4 Feb 2022

Scientists discover new genetic link to non-alcoholic inflammatory liver disease

Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat in the liver unrelated to alcohol abuse or other liver diseases.

11 Nov 2021

Study identifies a novel role for regulatory protein Bach1 in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, afflicting more than 10 million people worldwide and more than one million Americans. While there is no cure for PD, current therapies focus on treating motor symptoms and fail to reverse, or even address, the underlying neurological damage.

26 Oct 2021

Neuroinflammation protein associated with sex-specific survival differences in glioblastoma patients

Scientists have discovered a new link that could bring the scientific and medical community closer to understanding why glioblastoma, the most common malignant brain tumor, is deadlier in males than females.

19 Oct 2021

Bacteria-derived curli amyloid fibril promotes neurodegeneration in the host

Increasing evidence points to the fact that gut microbiota performs a vital role in regulating the advancement of neurodegenerative diseases like Alzheimer’s.

9 Sep 2021

Metabolite produced by gut microbes found to be involved in regulating commensal bacteria

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria.

20 Jul 2021

Researchers identify a novel pathomechanism leading to Usher syndrome

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses.

12 Jul 2021

Study finds a link between progression of Alzheimer’s disease and corpuscles in cell nuclei

Studies conducted on patients’ tissue as well as mini-brains created from stem cells have provided a better insight into Alzheimer’s disease.

15 Jun 2021

New label-free immune profiling assay to assess rapidly changing host immune response

Researchers from Critical Analytics for Manufacturing Personalized-Medicine (CAMP), an Interdisciplinary Research Group (IRG) at the Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, have developed a new label-free immune profiling assay that profiles the rapidly changing host immune response in case of infection, in a departure from existing methods that focus on detecting the pathogens themselves, which can often be at low levels within a host.

26 Mar 2021

Pathophysiology News and Research

Low protein synthesis in humans causes rare intestinal disease

Rare and protective loss-of-function mutations offer possible NAFLD drug targets

Scientists decipher a direct dialog between the gut microbiota and the brain

HIF-1alpha inhibitor preserves the activity of insulin-producing beta cells in diabetic mice

New database provides extensive information on kinase-associated neural protein phosphorylation

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

Largest genome study identifies new genetic risk factors for migraine

Scientists discover new genetic link to non-alcoholic inflammatory liver disease

Study identifies a novel role for regulatory protein Bach1 in Parkinson's disease

Neuroinflammation protein associated with sex-specific survival differences in glioblastoma patients

Bacteria-derived curli amyloid fibril promotes neurodegeneration in the host

Metabolite produced by gut microbes found to be involved in regulating commensal bacteria

Researchers identify a novel pathomechanism leading to Usher syndrome

Study finds a link between progression of Alzheimer’s disease and corpuscles in cell nuclei

New label-free immune profiling assay to assess rapidly changing host immune response

Gender difference accounts for major psychiatric disorders

Abnormalities in cholesterol transport protein associated with schizophrenia

Researchers create 3D miniature organs that precisely mimic human tissues

Molecular markers in the blood can predict severe COVID-19 outcomes

Researchers use new decoding method to identify novel proteins encoded by HSV-1

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