RNA Sequencing News and Research

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Researchers Uncover How Macrophages Respond to Infection Stress

Fighting infections requires speed and accuracy. A team of researchers from CeMM and MedUni Vienna, led by Christoph Bock and Matthias Farlik, explored how macrophages—the body’s initial responders—handle this stress.

11 Aug 2025

New RNA Sequencing Technology Uncovers Molecular Drivers of Cellular Differentiation

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

8 Aug 2025

AI Tool Accelerates Hunt for Elusive Genome‐Encoded Microproteins

Proteins sustain life as we know it, serving many important structural and functional roles throughout the body.

1 Aug 2025

Blocking TG2 Could Help Immune Cells Attack Ovarian Tumors

The study reveals TG2's role in ovarian cancer metastasis, suggesting that its inhibition could re-educate the immune system for better anti-tumor efficacy.

30 Jul 2025

Scientists Uncover How New Genes Are Switched On in Fruit Flies

Most genes are ancient and shared across species. But a small subset of genes are relative newcomers, spontaneously emerging from stretches of DNA that once encoded nothing at all.

14 Jul 2025

New Cellular Signature Reveals Why Some Prostate Cancers Resist Standard Treatment

A new study from University of Michigan Rogel Cancer Center researchers identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment.

9 Jul 2025

Reactivating a Genetic Switch Restores Ear Regeneration in Mice

By flipping an evolutionarily disabled genetic switch involved in Vitamin A metabolism, researchers have enabled ear tissue regeneration in mice. Unlike some animals such as fish and salamanders, mammals have limited capacity to regenerate damaged tissues or organs fully.

27 Jun 2025

Worm Species Reveal Deep Genetic Similarities Across Evolutionary Time

Two species of worms, separated by 20 million years of evolution, have been found to activate their genes in nearly identical ways as they develop from a single cell to a fully formed organism.

27 Jun 2025

Parse Biosciences GigaLab to Support Mount Sinai Researchers in Generating One of the Largest Alzheimer's and Parkinson's Single Cell Datasets

Parse Biosciences today announced their commitment to support researchers from the Icahn School of Medicine at Mount Sinai in generating one of the largest single cell datasets focused on understanding alternative splicing events in the cells of Alzheimer's and Parkinson's patients.

From Parse Biosciences 26 Jun 2025

Fusion Genes Emerge as Key Drivers in Cancer Development

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.

25 Jun 2025

Organotypic Model of the Human Gut Epithelium Demonstrates Genetic Determinants of Shigella Colonization

A study in Nature Genetics uses organotypic gut models to reveal genome-wide genetic determinants of Shigella colonization, spotlighting type III secretion system effectors as crucial for early infection.

20 Jun 2025

New STAMP Technique Combines Microscopy with Single-Cell RNA Analysis

Single-cell RNA sequencing provides scientists with important information about gene expression in health and disease.

18 Jun 2025

Quantifying Breast Cancer Heterogeneity Through Single-Cell Transcriptomics

Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels.

18 Jun 2025

New Technique Revolutionizing Single-Cell Analysis with Lower Costs and Greater Scale

A new single-cell RNA analysis method, STAMP, significantly reduces costs and biases, allowing for comprehensive profiling of diverse cell populations.

13 Jun 2025

New Platform Technology Promises to Generate Hard-to-Get Human Cells

This study presents a fast method for generating human microglia from iPSCs, paving the way for breakthroughs in neurodegenerative disease research.

11 Jun 2025

Electro-bioprinting as a Tool to Study Early Human Embryonic Development

Bioprinted epiblast-like structures mimic early human embryonic development, offering a scalable, ethical platform to study gastrulation and tissue formation.

11 Jun 2025

Spatial Transcriptomics Reshapes Musculoskeletal Research and Therapy

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

10 Jun 2025

Reversible DNA Modification Controls Replication and Gene Activity

Study uncovers ADP-ribosylation's role in Mycobacterium tuberculosis, showing how DNA modification controls replication and gene expression for survival.

23 May 2025

Addressing Protein Leakage in Cells to Improve the Accuracy of Single-Cell Proteomic Data

A new study in Nature Communications presents a solution to protein leakage in single-cell proteomics, improving data quality by identifying and excluding permeabilized cells using a machine learning classifier.

19 May 2025

Protein Balance Offers Key to Overcoming Immunotherapy Resistance

Immunotherapy uses a person's own immune system to fight cancer. Immune checkpoint inhibitors are one class of immunotherapy that block specific proteins from slowing the immune response.

15 May 2025