Immune System News and Research

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Macrophages likely to be a potential target for ER+ breast cancer

Most immunotherapies that aim to increase T cell activity are ineffective in treating estrogen receptor-positive (ER+) breast cancer. A new study of invasive ER+ breast cancers led by researchers at the University of Pittsburgh School of Medicine implies that targeting a different type of immune cell called macrophages may be a more effective approach.

From University of Pittsburgh 20 Mar 2023

Study discovers the ability of certain blood immune cells to proliferate

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

20 Mar 2023

New antibody "cocktail" may help counter the Lassa virus

The finding, made with the use of the Advanced Photon Source, shows a new way to exploit monoclonal antibodies to subvert the "shield" of the virus, potentially paving the way for new therapies.

20 Mar 2023

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

Most immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer.

20 Mar 2023

Common commensal gut bacterium uses phase separation of Rho factor to thrive in the mammalian gut

The common commensal gut bacterium Bacteroides thetaiotaomicron uses phase separation of the transcription termination factor Rho to colonize and thrive in the mammalian gut, according to a new study in mice.

17 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

High doses of sucralose limit T cell proliferation and differentiation

Scientists at the Francis Crick Institute have found that high consumption of a common artificial sweetener, sucralose, lowers activation of T-cells, an important component of the immune system, in mice.

16 Mar 2023

New therapeutic approaches to treat autoimmune diseases using a metabolite

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

16 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

Bile salt hydrolase cocktails may offer a new approach to inhibit C. diff colonization

Not all probiotics are created equal. In a new study, researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by both altering existing bile acids and by creating a new class of bile acids within the gut's microbial environment.

14 Mar 2023

New framework to identify possible viral hazards to human health

The majority of what scientists know about viruses in animals comes from the list of nucleotides that constitute their genomic sequence, which, although useful, provides relatively few signals about a virus’ propensity to infect people.

14 Mar 2023

New perspective on how immune cells perceive viruses and other threats

A textbook chapter on the immune system may need to be revised as a result of a new study from Aarhus University.

14 Mar 2023

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

The human intestine is an environment inhabited by many bacteria and other microorganisms collectively known as the gut microbiome, gut microbiota or intestinal flora. In most people, it contributes to wellness. A healthy gut indicates a stronger immune system, improved metabolism, and a healthy brain and heart, among other functions.

14 Mar 2023

Developing new therapies that leverage the host immune system

Yersinia bacteria cause a variety of human and animal diseases, the most notorious being the plague, caused by Yersinia pestis. A relative, Yersinia pseudotuberculosis, causes gastrointestinal illness and is less deadly but naturally infects both mice and humans, making it a useful model for studying its interactions with the immune system.

14 Mar 2023

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Microorganisms live in or on almost every part of the human body and play an important role in the regulation of normal human processes. As a result, changes in the number or type of microorganisms, also known as the microbiome, can contribute to disease and altered responses to therapy, including cancer treatment.

14 Mar 2023

Rest boosts the immune system of migratory birds, study finds

Exercising too much and not getting enough rest is bad for your health. A new study from Lund University in Sweden shows that the same is true for migratory birds. They need to rest not only to renew their energy levels but also in order to boost their immune system.

13 Mar 2023

Immune System News and Research

Macrophages likely to be a potential target for ER+ breast cancer

Study discovers the ability of certain blood immune cells to proliferate

New antibody "cocktail" may help counter the Lassa virus

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

Common commensal gut bacterium uses phase separation of Rho factor to thrive in the mammalian gut

Highlighting a potential sex‐specific precision immunotherapy strategy

High doses of sucralose limit T cell proliferation and differentiation

New therapeutic approaches to treat autoimmune diseases using a metabolite

High correlation between the product of a gene in the majority of cancers

Bile salt hydrolase cocktails may offer a new approach to inhibit C. diff colonization

New framework to identify possible viral hazards to human health

New perspective on how immune cells perceive viruses and other threats

Analyzing the antimicrobial resistance profile of the main agent of urinary tract infections

Developing new therapies that leverage the host immune system

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Rest boosts the immune system of migratory birds, study finds

Investigating the potential cellular effects of C-reactive protein

Pathogenic fungus binds to a human protein to escape elimination from lung cells

Deeper understanding of T-cell responses may lead to better, more personalized immunotherapies

Pentamer shape of C-reactive protein can suppress the immune response in inflammatory disease

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