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Atomic force spectroscopy probes cellular biomechanics in response to drugs in hypoxia

Oncotarget published "Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy" which reported that by exploiting single-cell, force spectroscopy methods, the authors probed biophysical and biomechanical kinetics of brain, breast, prostate, and pancreatic cancer cells with standard chemotherapeutic drugs in normoxia and hypoxia over 12-24 hours.

20 Jul 2021

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

20 Jul 2021

Study confirms long-term immune system responses of adenovirus vaccines for COVID-19

Researchers from the University of Oxford suggest that adenovirus vaccine vectors may create strong long-term immune system responses.

19 Jul 2021

Illinois scientists make it easier for farmers to choose plant biostimulants

Corn growers can choose from a wide array of products to make the most of their crop, but the latest could bring seaweed extract to a field near you. The marine product is just one class in a growing market of crop biostimulants marketed for corn.

16 Jul 2021

New study identifies two genetic regions linked to cluster headache

Scientists have performed the largest-ever study seeking genetic markers for cluster headache.

16 Jul 2021

Updated Families SHARE workbook helps people use family history to assess disease risk

The Families SHARE workbook was developed by researchers at the NHGRI, which is part of the National Institutes of Health (NIH).

12 Jul 2021

Study reveals how fine-tuning the immune system can improve vaccines, reduce disease severity

Immunologists have discovered a molecular route that regulates how crucial immune cells evolve into the immune system’s functioning components.

9 Jul 2021

Universal stem cells exhibit the potential for more cost-effective cell therapy

Researchers have demonstrated that gene-edited cellular treatments can effectively treat cardiovascular and pulmonary disorders.

8 Jul 2021

Study on memory T cells of COVID-19 convalescent patients could power effective vaccine strategies

Researchers have discovered that a majority of the COVID-19 convalescent patients develop and maintain T cell memory for more than 10 months.

7 Jul 2021

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

New method can improve the efficacy of promising treatment for recurrent glioblastoma

A promising treatment for melanoma and other types of cancers is neoadjuvant immune checkpoint blockade (ICB).

1 Jul 2021

New nanobodies could fight against SARS-CoV-2 variants

Looking for a new strategy in the long-running battle against the SARS-CoV-2 virus, researchers have developed nanobodies.

23 Jun 2021

New technique boosts the efficacy of future malaria vaccines

A new technique for obtaining pure malaria parasites from infected mosquitos could speed up the development of novel, more powerful malaria vaccinations.

21 Jun 2021

New packaging film can keep strawberries fresh for up to 12 days

Québec produces more strawberries than any other Canadian province. Strawberries are delicate and difficult to keep fresh. In response to this challenge, Monique Lacroix, a professor at at the Institut national de la recherche scientifique (INRS), and her team have developed a packaging film that can keep strawberries fresh for up to 12 days.

16 Jun 2021

Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

8 Jun 2021

Some Type 2 diabetes patients could benefit from bone marrow stem cell transplants, study shows

Type 2 diabetes patients who are not overweight and who have had the disorder for less than a decade can benefit from stromal stem cells transplanted from their own bone marrow, according to a study published today in STEM CELLS Translational Medicine.

4 Jun 2021

Diet plays a crucial role in liver disease outcome, mouse model shows

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.

2 Jun 2021

Researchers discover a new, effective way to treat aggressive blood cancer in children

Australian scientists have found what could prove to be a new and effective way to treat a particularly aggressive blood cancer in children.

31 May 2021

Study: REAER is a promising therapy for improving the lives of patients with multiple sclerosis

A team of multiple sclerosis (MS) experts at Kessler Foundation led the first pilot randomized controlled trial of robotic-exoskeleton assisted exercise rehabilitation (REAER) effects on mobility, cognition, and brain connectivity in people with substantial MS-related disability.